maskNMF: A denoise-sparsen-detect approach for extracting neural signals from dense imaging data

Kavli Affiliate: Liam Paninski, Darcy Peterka | Authors: Amol Pasarkar, Ian Kinsella, Pengcheng Zhou, Melissa Wu, Daisong Pan, Jiang Lan Fan, Zhen Wang, Lamiae Abdeladim, Darcy S. Peterka, Hillel Adesnik, Na Ji and Liam Paninski | Summary: A number of calcium imaging methods have been developed to monitor the activity of large populations of neurons. […]


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Higher Order Nyquist Zone Sampling with RFSoC Data Converters for Astronomical and High Energy Physics Readout Systems

Kavli Affiliate: Zeeshan Ahmed | First 5 Authors: Chao Liu, Zeeshan Ahmed, Shawn W. Henderson, Ryan Herbst, Larry Ruckman | Summary: From generation to generation, the maximum RF frequency and sampling rate of the integrated data converters in RF system-on-chip (RFSoC) family devices from Xilinx increases significantly. With the integrated digital mixers and up and […]


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Machine assisted annotation in neuroanatomy

Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, David Kleinfeld, Beth Friedman and Yoav Freund | Summary: One routine and necessary, yet time-consuming task in neuroanatomy is the annotation of labeled cells relative to the background. Currently, staining and imaging techniques enable the marking of specific cell groups with fluorescent dyes. Modern high throughput scanning […]


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All-dielectric high-Q dynamically tunable transmissive metasurfaces

Kavli Affiliate: Harry A. Atwater | First 5 Authors: Ruzan Sokhoyan, Claudio U. Hail, Morgan Foley, Meir Y. Grajower, Harry A. Atwater | Summary: Active metasurfaces, which are arrays of actively tunable resonant elements, can dynamically control the wavefront of the scattered light at a subwavelength scale. To date, most active metasurfaces that enable dynamic […]


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Single-cell analysis of prenatal and postnatal human cortical development

Kavli Affiliate: Arnold R. Kriegstein | Authors: Dmitry Velmeshev, Yonatan Perez, Zihan Yan, Jonathan E Valencia, David R Castaneda-Castellanos, Li Wang, Lucas Schirmer, Simone Mayer, Brittney Wick, Shaohui Wang, Tomasz J. Nowakowski, Mercedes Paredes, Eric J. J. Huang and Arnold Kriegstein | Summary: We analyze more than 700,000 single-nucleus RNA-seq profiles from 106 donors during […]


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Gravitational Wave Science in the Mid-Band with Atom Interferometers

Kavli Affiliate: Peter W. Graham | First 5 Authors: Sebastian Baum, Zachary Bogorad, Peter W. Graham, , | Summary: Gravitational Waves (GWs) have been detected in the $sim 100$ Hz and nHz bands, but most of the gravitational spectrum remains unobserved. A variety of detector concepts have been proposed to expand the range of observable […]


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Particle-hole asymmetric ferromagnetism and spin textures in the triangular Hubbard-Hofstadter model

Kavli Affiliate: Cheng Peng | First 5 Authors: Jixun K. Ding, Luhang Yang, Wen O. Wang, Ziyan Zhu, Cheng Peng | Summary: In a lattice model subject to a perpendicular magnetic field, when the lattice constant is comparable to the magnetic length, one enters the "Hofstadter regime," where continuum Landau levels become fractal magnetic Bloch […]


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Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Azucena Perez-Canamas, Hongping Ye, Xianlin Han and Stephen M. Strittmatter | Summary: TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyloid fibrils of […]


Continue.. Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Categorization dynamically alters representations in human visual cortex

Kavli Affiliate: John Serences | Authors: Margaret M Henderson, John T Serences and Nuttida Rungratsameetaweemana | Summary: Everyday visual search tasks require objects to be categorized according to behavioral goals. For example, when searching for an apple at the supermarket, one might first find the Granny Smith apples by separating all visible apples into the […]


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Real Effect or Bias? Best Practices for Evaluating the Robustness of Real-World Evidence through Quantitative Sensitivity Analysis for Unmeasured Confounding

Kavli Affiliate: Xiang Zhang | First 5 Authors: Douglas Faries, Chenyin Gao, Xiang Zhang, Chad Hazlett, James Stamey | Summary: The assumption of no unmeasured confounders is a critical but unverifiable assumption required for causal inference yet quantitative sensitivity analyses to assess robustness of real-world evidence remains underutilized. The lack of use is likely in […]


Continue.. Real Effect or Bias? Best Practices for Evaluating the Robustness of Real-World Evidence through Quantitative Sensitivity Analysis for Unmeasured Confounding