Kavli Affiliate: Yi Zhou | First 5 Authors: Siyu Long, Yi Zhou, Xinyu Dai, Hao Zhou, | Summary: Drug design is a crucial step in the drug discovery cycle. Recently, various deep learning-based methods design drugs by generating novel molecules from scratch, avoiding traversing large-scale drug libraries. However, they depend on scarce experimental data or […]
Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Hyeon-Cheol Park, Haolin Zhang and Xingde Li | Summary: Abstract Two-photon fluorescence microscopy has enjoyed its wide adoption in neuroscience. Head-mounted miniaturized fiberscopes offered an exciting opportunity for enabling neural imaging in freely-behaving animals with high 3D resolution. Here we propose a dual-fiberscope rotary joint based on […]
Kavli Affiliate: Roland Vanderspek | First 5 Authors: Christopher R. Mann, David Lafrenière, Diana Dragomir, Samuel N. Quinn, Thiam-Guan Tan | Summary: We present a successful validation of the long-period ($91.68278^{+0.00032}_{-0.00041}$ days) transiting sub-Neptune planet TOI-1221 b (TIC 349095149.01) around a Sun-like (m$_{rm V}$=10.5) star. We combine {it TESS} light curve measurements and ground-based time-series […]
Kavli Affiliate: Samuel Pfaff | Authors: Lydia Daboussi, Giancarlo Costaguta, Miriam Gullo, Veronica Pessino, Brendan O’Leary, Karen Lettieri, Shawn Driscoll and Samuel L. Pfaff | Summary: Abstract Schwann cells respond to acute axon damage by transiently transdifferentiating into specialized repair cells that restore sensorimotor function. However, the molecular systems controlling repair cell formation and function […]
Kavli Affiliate: Wayne Hu | First 5 Authors: Lucas F. Secco, Tanvi Karwal, Wayne Hu, Elisabeth Krause, | Summary: We explore a re-parameterization of the lensing amplitude tension between weak lensing (WL) and cosmic microwave background (CMB) data and its implications for a joint resolution with the Hubble tension. Specifically, we focus on the lensing […]
Kavli Affiliate: Andrew Vanderburg | First 5 Authors: Mary Anne Limbach, Andrew Vanderburg, Kevin B. Stevenson, Simon Blouin, Caroline Morley | Summary: We demonstrate that the James Webb Space Telescope (JWST) can detect infrared (IR) excess from the blended light spectral energy distribution of spatially unresolved terrestrial exoplanets orbiting nearby white dwarfs. We find that […]
Kavli Affiliate: Michael Miller | Authors: Han Zhu, Gaowei Wang, Kim-Vy Nguyen-Ngoc, Dongsu Kim, Michael Miller, Georgina Goss, Jenna Kovsky, Austin R Harrington, Diane Saunders, Rebecca Melton, Alvin C Powers, Sebastian Preissl, Francesca M Spagnoli, Kyle J Gaulton and Maike Sander | Summary: Abstract Pancreatic islet cells derived from human pluripotent stem cells hold great […]
Kavli Affiliate: Mark Ellisman | Authors: Hugo Calligaro, Azarin Shoghi, Xinyue Chen, Keun-Young Kim, Yu Hsin Liu, Brian Khov, Benjamin Finander, Hiep Le, Mark H Ellisman and Satchidananda Panda | Summary: Abstract The suprachiasmatic nucleus (SCN) in the hypothalamus of the vertebrate brain is the central pacemaker regulating circadian rhythmicity throughout the body. The SCN […]
Kavli Affiliate: Fred Gage | Authors: Sarah L Parylak, Fan Qiu, Sara B Linker, Iryna S Gallina, Christina K Lim, David Preciado, Aidan H McDonald and Fred H Gage | Summary: Abstract Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus function. Although […]
Kavli Affiliate: Ulrich Sperhake | First 5 Authors: Vitor Cardoso, David Hilditch, Krinio Marouda, José Natário, Ulrich Sperhake | Summary: Stationary compact astrophysical objects such as black holes and neutron stars behave as classical systems from the gravitational point of view. Their (observable) curvature is everywhere "small". Here we investigate whether mergers of such objects, […]