Two-dimensional Heisenberg models with materials-dependent superexchange interactions

Kavli Affiliate: Bo Gu | First 5 Authors: Jia-Wen Li, Zhen Zhang, Jing-Yang You, Bo Gu, Gang Su | Summary: The two-dimensional (2D) van der Waals ferromagnetic semiconductors, such as CrI$_3$ and Cr$_2$Ge$_2$Te$_6$, and the 2D ferromagnetic metals, such as Fe$_3$GeTe$_2$ and MnSe$_2$, have been obtained in recent experiments and attracted a lot of attentions. […]


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White dwarf — red giant star binaries as Type Ia supernova progenitors: with and without magnetic confinement

Kavli Affiliate: Saul A. Rappaport | First 5 Authors: Iminhaji Ablimit, Philipp Podsiadlowski, Rosanne Di Stefano, Saul A. Rappaport, James Wicker | Summary: Various white-dwarf (WD) binary scenarios have been proposed trying to understand the nature and the diversity of Type Ia supernovae (SNe Ia). In this work, we study the evolution of carbon-oxygen WD […]


Continue.. White dwarf — red giant star binaries as Type Ia supernova progenitors: with and without magnetic confinement

Bifurcation instructed design of multistate machines

Kavli Affiliate: Itai Cohen | First 5 Authors: Teaya Yang, David Hathcock, Yuchao Chen, Paul McEuen, James P. Sethna | Summary: We propose a novel design paradigm for multistate machines where transitions from one state to another are organized by bifurcations of multiple equilibria of the energy landscape describing the collective interactions of the machine […]


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Evidence for AGN-Regulated Cooling in Clusters at $z sim 1.4$: A Multi-Wavelength View of SPT-CL J0607-4448

Kavli Affiliate: Bradford A. Benson | First 5 Authors: Megan Masterson, Michael McDonald, Behzad Ansarinejad, Matthew Bayliss, Bradford A. Benson | Summary: We present a multi-wavelength analysis of the galaxy cluster SPT-CL J0607-4448 (SPT0607), which is one of the most distant clusters discovered by the South Pole Telescope (SPT) at $z=1.4010pm0.0028$. The high-redshift cluster shows […]


Continue.. Evidence for AGN-Regulated Cooling in Clusters at $z sim 1.4$: A Multi-Wavelength View of SPT-CL J0607-4448

Unification of thermal and quantum noise in gravitational-wave detectors

Kavli Affiliate: Lee McCuller | First 5 Authors: Chris Whittle, Lee McCuller, Vivishek Sudhir, Matthew Evans, | Summary: Contemporary gravitational-wave detectors are fundamentally limited by thermal noise — due to dissipation in the mechanical elements of the test mass — and quantum noise — from the vacuum fluctuations of the optical field used to probe […]


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Dissipative Optomechanics in High-Frequency Nanomechanical Resonators

Kavli Affiliate: Simon Groblacher | First 5 Authors: André G. Primo, Pedro V. Pinho, Rodrigo Benevides, Simon Gröblacher, Gustavo S. Wiederhecker | Summary: The coherent transduction of information between microwave and optical domains is a fundamental building block for future quantum networks. A promising way to bridge these widely different frequencies is using high-frequency nanomechanical […]


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Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

Kavli Affiliate: Stephen Strittmatter | Authors: Hideyuki Takahashi, Sanaea Bhagwagar, Sarah H. Nies, Marius T. Chiasseu, Guilin Wang, Ian R. Mackenzie and Stephen M. Strittmatter | Summary: Comorbid proteinopathies are observed in many neurodegenerative disorders including Alzheimer’s disease (AD), increase with age, and influence clinical outcomes, yet the mechanisms remain ill-defined. Here, we show that […]


Continue.. Reduced progranulin increases tau and α-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Kavli Affiliate: Shawn Ferguson | Authors: Narayana Yadavalli and Shawn M. Ferguson | Summary: Variants in leucine rich repeat kinase 2 (LRRK2) that increase kinase activity confer risk for sporadic and familial forms of Parkinson’s disease. However, LRRK2-dependent cellular processes responsible for disease risk remain uncertain. Here we show that LRRK2 negatively regulates lysosome degradative […]


Continue.. LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Kavli Affiliate: Nenad Sestan | Authors: Suel-Kee Kim, Seungmae Seo, Genevieve Stein-O’Brien, Amritha Jaishankar, Kazuya Ogawa, Nicola Micali, Victor Luria, Amir Karger, Yanhong Wang, Thomas M. Hyde, Joel E. Kleinman, Ty Voss, Elana J. Fertig, Joo-Heon Shin, Roland Bürli, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Joshua G. Chenoweth, Daniel J. Hoeppner, Nenad […]


Continue.. Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury

Kavli Affiliate: David Rowitch | Authors: Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric J Huang, Manideep Chavali, Shane Liddelow, David Rowitch, Andreina Schoeberlein and Amanda Brosius Lutz | Summary: The role of reactive astrocytes in perinatal white matter injury (WMI) is unclear. In a mouse model of WMI, we provide evidence that impairing […]


Continue.. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury