dbos – Page 16 – Kavli Institute Pre-Print Publications

Pak, a downstream gene of ecdysone signaling, determines left-right polarity in the Drosophila brain through neuronal cell chirality

Posted by dbos July 18, 2025July 28, 2025UCSD / Salk

Kavli Affiliate: Ann-Shyn Chiang | Authors: So Sakamura, Komomo Suyama, Akari Tsujita, Fu-yu Hsu, Atsushi Tamada, Tomoyuki Miyashita, Minoru Saitoe, Ann-Shyn Chiang, Mikiko Inaki and Kenji Matsuno | Summary: Left-right (LR) asymmetry is a conserved characteristic of the brain in various animals and is related to its higher-order functions. The Drosophila brain has an LR […]

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Non-visual light modulates behavioral memory and gene expression in C. elegans

Posted by dbos July 16, 2025July 28, 2025UCSF

Kavli Affiliate: Noelle L’Etoile | Authors: Zhijian Ji, Bingying Wang, Junqiang Liu, Rashmi K. Chandra, Winnie Yang, Yong Long, Michael Egan, Noelle L’Etoile and Dengke K. Ma | Summary: Visible light influences a range of physiological processes, yet how animals respond to it independently of the visual system remains largely unknown. Here, we uncover a […]

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Statistically valid explainable black-box machine learning: applications in sex classification across species using brain imaging

Posted by dbos July 16, 2025July 28, 2025Hopkins

Kavli Affiliate: Joshua Vogelstein | Authors: Tingshan Liu, Jayanta Dey, Beiya Xu, Samuel S Alldritt, Karl-Heinz Nenning, Kyoungseob Byeon, Ting Xu and Joshua T. Vogelstein | Summary: Sex classification using neuroimaging data has the potential to revolutionize personalized diagnostics by revealing subtle structural brain differences that underlie sex-specific disease risks. Despite the promise of machine […]

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Cell type-specific barcoding reveals the projectional architecture of the mouse midbrain dopaminergic system

Posted by dbos July 15, 2025July 28, 2025Hopkins

Kavli Affiliate: Justus M Kebschull | Authors: Hyopil Kim, Cheng Xu, Craig Washington, Maggie Lowman and Justus M Kebschull | Summary: Brain-wide neural circuits are formed by the diverse axonal branching patterns of many individual neurons. Here we introduce POlNTseq (projections of interest by sequencing), a high-throughput and user-friendly barcoded connectomics method that uses cell […]

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Dynamic extracellular interactions with AMPA receptors

Posted by dbos July 14, 2025July 28, 2025Hopkins

Kavli Affiliate: Richard Huganir | Authors: Hana Goldschmidt Merrion, Casey N. Barber, Santosh S. Renuse, Jevon Cutler, Simion Kreimer, Alexei M. Bygrave, David J. Meyers, William Dylan Hale, Akhilesh Pandey and Richard L. Huganir | Summary: Synaptic plasticity in the central nervous system enables the encoding, storing, and integrating new information. AMPA-type glutamate receptors (AMPARs) […]

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Genome editing of phylogenetically distinct bacteria using portable retron-mediated recombineering

Posted by dbos July 9, 2025July 21, 2025UCSF

Kavli Affiliate: Seth Shipman | Authors: Alejandro Gonzalez-Delgado, Laura Bonillo-Lopez, Milo S Johnson, Nastassia Knoedlseder, Ching-Chung Ko, Yassir Lekbach, Jee-Hwan Oh, Hemaa Selvakumar, Michael C Wold, Zihan Yu, Virginia Aragon, Jeffrey A Gralnick, Marc Guell, Graham Hatfull, Benjamin Keith Keitz, Britt Koskella, Vivek K Mutalik, Jan Peter van Pijkeren and Seth Shipman | Summary: Advanced […]

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Inhibitory neurons marked by the connectivity molecule Kirrel3 regulate memory precision

Posted by dbos July 7, 2025July 21, 2025UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Arnulfo B.N. Tunon-Ortiz, Dimitri Trankner, Chandler M. Peterson, Omar Shennib, Fangfei Ye, Jiani Shi, Sarah N. Brockway, Olivia Katherine Raines, Abbey Mahnke, Matthew Grega, Keun-Young Kim, Mark Ellisman, James G. Heys, Moriel Zelikowsky and Megan E Williams | Summary: The homophilic adhesion molecule Kirrel3 drives synapse formation between dentate […]

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Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon

Posted by dbos July 7, 2025July 21, 2025UCSD / Salk

Kavli Affiliate: Robert E. Clark | Authors: Bert van den Berg, Emily Dunbar, Robert Clark, Arnaud Basle, Shenaz Allyjaun, Hector Newman, Julia Hubbard and Syma Khalid | Summary: Bacteriophages are bacterial viruses that provide alternatives to small-molecule drugs to combat infections by antibiotic-resistant bacteria. To infect a bacterial host, a phage needs to bind to […]

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Electrocorticographic Detection of Speech Networks in Glioma-infiltrated Cortex

Posted by dbos July 5, 2025July 14, 2025UCSF

Kavli Affiliate: Edward Chang | Authors: Vardhaan S Ambati, Amit S Persad, Jasleen Kaur, Sanjeev Herr, Emily Cunningham, Abraham Dada, Justyna O Ekert, Quinn Greicius, Alexander Silva, Paul McMillan Villalobos, Niels Olshausen, Youssef Sibih, Sena Oten, Hunter S. Yamada, Gray Umbach, Alexander A Aabedi, Wajd Al-Holou, Jacob Young, Madhumita Sushil, Edward F Chang, Mitchel S. […]

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Multimodal sensory overload in dopamine-deficient larval zebrafish leads to paradoxical kinesia

Posted by dbos July 4, 2025July 14, 2025UCSF

Kavli Affiliate: Su Guo | Authors: Krishnashish Bose, Su Guo and Karnika Bhardwaj | Summary: Paradoxical kinesia—the temporary alleviation of motor deficits by powerful, urgent stimuli in Parkinson’s disease (PD)—remains poorly understood at the neural circuit level. Through chemo-genetic ablation of tyrosine hydroxylase-expressing neurons in larval zebrafish and brain-wide calcium imaging under head-fixed, tail-free conditions, […]

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