Long-term memory performance optimization via Neural network-based curve fitting in Drosophila

Posted by dbos UCSD / Salk

Kavli Affiliate: Ann-Shyn Chiang | Authors: Yung-Ching Lu, Chih-Ying Chen, Ling-Hui Yen, Chi-Lien Yang, Ya-Ding Liu, Wen-Jun Chen, Kuan-Lin Feng, Ming-Chin Wu, Ann-Shyn Chiang, Da-Jeng Yao, Chih-Ming Ho, Shih-Hwa Chiou and Li-An Chu | Summary: Long-term memory (LTM) formation typically requires extensive training or highly salient experiences, limiting learning efficiency. Operant conditioning is generally thought […]


Continue.. Long-term memory performance optimization via Neural network-based curve fitting in Drosophila

Zinc coordination by the wheat rust effector AvrSr33 provides a structural scaffold required for immune recognition

Posted by dbos Rockefeller

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Jian Chen, Emily M Cross, Megan A Outram, Daniel S Yu, Jana Sperschneider, Melania Figueroa, Peter N Dodds and Simon J Williams | Summary: Interactions between plants and pathogens drive long-term co-evolution through cycles of effector diversification and immune recognition. Effectors play central roles in this molecular […]


Continue.. Zinc coordination by the wheat rust effector AvrSr33 provides a structural scaffold required for immune recognition

Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration

Posted by dbos Hopkins

Kavli Affiliate: Alex Kolodkin | Authors: Stephanie L Sarbanes, Jakub Ziak, Alex L Kolodkin and Antonina Roll-Mecak | Summary: Microtubule dynamics regulation is critical for neuronal development, yet how neurons regulate tubulin levels remains poorly understood. Tetratricopeptide repeat domain 5 (TTC5) mediates the co-translational degradation of tubulin transcripts in response to excess soluble tubulin, a.k.a. […]


Continue.. Tubulin autoregulation mediator TTC5 regulates neuronal morphology and migration

Searchlight Optimization Using Representational Similarity Analysis for Subject-Level Voxel Selection in Emotional State Decoding

Posted by dbos Hopkins

Kavli Affiliate: David Linden | Authors: Xuelei Wang, Jana Zweerings, Michael Lührs, Fengyu Cong, Klaus Mathiak, David E.J. Linden, Rainer Goebel, Assunta Ciarlo and David M. A. Mehler | Summary: Identifying informative voxels is a critical, yet challenging step in functional magnetic resonance imaging (fMRI), particularly for multivariate analyses involving multiple related conditions. Existing approaches […]


Continue.. Searchlight Optimization Using Representational Similarity Analysis for Subject-Level Voxel Selection in Emotional State Decoding

Decoding Chronic Pain States from Distributed Intracranial Recordings

Posted by dbos UCSF

Kavli Affiliate: Edward Chang | Authors: Jeremy Saal, Ankit N. Khambhati, Edward F. Chang and Prasad Shirvalkar | Summary: Chronic pain engages distributed cortical and subcortical circuits, and large-scale intracranial recordings in humans offer a valuable opportunity to characterize its neural signatures. Here, we recorded multi-day stereoelectroencephalography (sEEG) from six participants with refractory chronic neuropathic […]


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Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport

Posted by dbos UCSF

Kavli Affiliate: David Rowitch | Authors: Guy LAM, Zhaoyang Xu, Adrien M Vaquie, Stavros Vagionitis, Michael Perry, Omar de Faria, Jr., Georgios Solomou, John H Stockley, Gemma C Girdler, Daniel Yamamoto, Juan A Oses, Qianqian Zhang, Gregory Jordan, Laura R Morcom, Jacob Stillman, Hani S Mousa, Alma Burlingame, Murray Stewart, Hauke B. Werner, Andras Lakatos, […]


Continue.. Myelin basic protein is an RNA chaperone in microglial nuclear retro-transport

Functional segregation of body-brain signals in the area postrema

Posted by dbos UCSF

Kavli Affiliate: Zachary Knight | Authors: Alejandro Lopez-Cruz, Natalie S. Figueredo Burgos, Anna M Hakimi, Kathryn Xie, Mo Mao, Mahekdeep Kaur, Antionette Spina, Katie Choi, Longhui Qui, Teresa E Lever, Fiona M Gribble, Frank Reimann, Martin G Myers, Alice E Adriaenssens and Zachary A Knight | Summary: Nausea arises from activation of specialized neurons in […]


Continue.. Functional segregation of body-brain signals in the area postrema

Sleep to forget: active control of consolidation and forgetting by slow-wave sleep dynamics

Posted by dbos UCSF

Kavli Affiliate: Karunesh Ganguly | Authors: Ryan Golden, Mingxiao Wei, Samantha Coury, Aviv Mizrahi-Kliger, Karunesh Ganguly and Maxim Bazhenov | Summary: Sleep supports both the consolidation of new memories and the forgetting of others, but how the cortex flexibly controls these outcomes remains poorly understood. Recent work has shown that two types of Up states […]


Continue.. Sleep to forget: active control of consolidation and forgetting by slow-wave sleep dynamics

Flexible decisions arise from resource-rational memory sampling

Posted by dbos UCSD / Salk

Kavli Affiliate: Marcelo Mattar | Authors: Jonathan Nicholas, Sixing Chen and Marcelo G Mattar | Summary: Flexible decision making depends on retrieving and recombining memories. Yet because this process unfolds covertly, its governing principles remain unknown. Here we use gaze reinstatement to uncover the hidden dynamics and computational logic of memory retrieval during flexible behavior. […]


Continue.. Flexible decisions arise from resource-rational memory sampling

Adaptive Charge Modulation Enables Focal, Selective Spinal Cord Stimulation

Posted by dbos UCSD / Salk

Kavli Affiliate: Eiman Azim and Mark H. Tuszynski | Authors: Ritwik Vatsyayan, Fadi Khoury, Tara S Porter, Eleni Sinopoulou, Hadi Day, Samantha Russman, Rhea Montgomery-Walsh, Kaushik Shukla, Helen Saad, Andrew M Bourhis, Jihwan Lee, Karen J Tonsfeldt, Akira Nagamori, Hoi Sang U, David M Roth, Drew Hall, Sharona Ben-Haim, Eiman Azim, Tony L. Yaksh, Alexander […]


Continue.. Adaptive Charge Modulation Enables Focal, Selective Spinal Cord Stimulation