Age-related reorganization of locus coeruleus–cortical functional connectivity gradients

Kavli Affiliate: Maryam Ziaei | Authors: Arjun Dave, Shuer Ye, Xiaqing Lan, Alireza Salami, Heidi Jacobs and Maryam Ziaei | Summary: The locus coeruleus (LC) regulates attention, arousal, and adaptive behavior via widespread noradrenergic projections to cortex, yet its large-scale cortical organization and age-related vulnerability remain poorly understood. Using 7T MRI during naturalistic movie-viewing with […]


Continue.. Age-related reorganization of locus coeruleus–cortical functional connectivity gradients

Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Kavli Affiliate: Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Martin Kampmann, Manoj T Duraisingh and Leslie B Vosshall | Summary: Amino acid composition within a proteome is conventionally viewed as a property of individual protein function. However, specific nutrient scarcity has been shown to reshape which amino acids are encoded in the genome of microbes. […]


Continue.. Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth

Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes

Kavli Affiliate: Erich Jarvis and Leslie B. Vosshall | Authors: Leah Houri-Zeevi, Philipp Brand, Irene Arnoldi, Alexandra E DeFoe, Jennifer R Balacco, Nadav Shai, Alex Makunin, Umberto Palatini, Takako Toma, Takao Okazawa, Christopher M Stone, Anita Schiller, Olivier Fedrigo, Erich D Jarvis, Mara KN Lawniczak, Ichiro Miyagi, Paolo Gabrieli and Leslie B Vosshall | Summary: […]


Continue.. Convergent evolutionary loss of chemosensory and blood-feeding pathways in non-blood-feeding mosquitoes

Anomalous Pressure-Enhanced Polarization in Sliding Ferroelectrics

Kavli Affiliate: Brad Ramshaw | Summary:Hydrostatic pressure commonly suppresses polarization in conventional displacive ferroelectrics by weakening the off-center ionic distortion. Sliding ferroelectrics may provide a contrasting case because their polarization arises from stacking-dependent interlayer charge transfer rather than intra-unit-cell ionic displacement. Here, hydrostatic pressure is shown to enhance, rather than suppress, the polarization of parallel-stacked […]


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Hunger reconfigures a reward learning circuit into a memory competent mode

Kavli Affiliate: Rui Costa | Authors: Annie Park, Bhagyashree Senapati, Nino Mancini, Youchong Zhang, Juliana Choi, Ian Cone, Christoph D Treiber, Rui Ponte Costa, Lisa M Fenk, Salil Sanjay Bidaye and Scott Waddell | Summary: Internal states such as hunger dynamically reshape activity across circuits to support resource seeking. Neuromodulation provides a means of controlling […]


Continue.. Hunger reconfigures a reward learning circuit into a memory competent mode

Protein hunger-driven nitrogen flow from phospholipids to amino acids in Drosophila

Kavli Affiliate: Qili Liu | Authors: Qili Liu, Tianji Ma, Guangyan Wu, Lauren Tham, Madison Palarca-Wong, Sharon Vaz, Nick Allen, Carrie Shao, Ashley Tsai, Richard W. Song and Pamela M. England | Summary: Protein is unique among macronutrients due to its nitrogen content and that its building blocks, essential amino acids, cannot be synthesized by […]


Continue.. Protein hunger-driven nitrogen flow from phospholipids to amino acids in Drosophila

Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning

Kavli Affiliate: Vikram Chib | Authors: Naser Al-Fawakhiri, Vikram S. Chib and Samuel D. McDougle | Summary: Motor learning depends on the integration of several, often competing signals, including reward and punishment (which guide learning the value of actions via reinforcement learning) and sensorimotor errors (which refine the execution of actions via motor adaptation). If […]


Continue.. Instrumental-Motor Transfer: The Relative Value of Competing Movement Goals Modulates Implicit Motor Learning

Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging

Kavli Affiliate: Michael Miller | Authors: Emre Caglayan, Ishaan Lamba, Monica Devi Manam, Benjamin Finander, Lovelace J. Luquette, David Exposito-Alonso, Sijing Zhao, Bowen Jin, Michael B Miller, Peter J Park, Chet C. Sherwood and Christopher A Walsh | Summary: Human brain aging is frequently studied in model mammals that rarely show the natural age-related neurodegenerative […]


Continue.. Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging

Molecular Beam Epitaxy of AgTaO3

Kavli Affiliate: Darrell Schlom | Summary:We report the first synthesis of single-crystal AgTaO3 thin films using molecular-beam epitaxy (MBE). High-quality epitaxial AgTaO3 films were grown on both (001)- and (111)-oriented SrTiO3 substrates using sequential deposition of atomic silver and TaO2 layers under an ozone/oxygen atmosphere (80 % O3 + 20 % O2). X-ray diffrac- tion […]


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Combining physical models with dynamically acquired experimental information for the optimization of multicomponent NASICON fast ionic conductors in a self-driving laboratory

Kavli Affiliate: Gerbrand Ceder| Summary:Elemental substitution within existing structural frameworks is a widely applied strategy for developing advanced materials. Yet, optimizing target properties while maintaining phase purity usually demands extensive trial-and-error, which becomes substantially inefficient when navigating a complex design space. Here, we introduce a strategy that simultaneously and dynamically assesses composition-dependent synthetic accessibility and […]


Continue.. Combining physical models with dynamically acquired experimental information for the optimization of multicomponent NASICON fast ionic conductors in a self-driving laboratory