August 25, 2026 – Kavli Institute Pre-Print Publications

TxNova: recovery of recurrent unannotated intergenic splice loci from existing bulk RNA-seq alignments

Posted by dbos August 25, 2026September 9, 2026Rockefeller

Kavli Affiliate: Li Zhao | Authors: Zhao Li, Aaron James and Shengxuan Li | Summary: Background Reference catalogs such as GENCODE capture most stably expressed mammalian genes but may not include condition-restricted or low-abundance transcripts. Reads supporting unannotated intergenic splice junctions are generally absent from annotation-restricted gene-count matrices; transcript assemblers may reconstruct a subset as novel […]

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Vangl2 acts in distinct cell types to establish bidirectional hair-bundle polarity and maintains tissue-wide alignment in zebrafish neuromasts

Posted by dbos August 25, 2026September 9, 2026Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Swarna Jeewajee, Francesco Gianoli, Maria Jussila, Brian Ciruna, Aaron Steiner, Adrian Jacobo and Albert James Hudspeth | Summary: The conserved core planar cell polarity (PCP) pathway orients cells and subcellular structures within an epithelium through asymmetric protein localization and intercellular communication(1–4). In vestibular organs and lateral-line neuromasts, mechanosensory […]

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Unifying error and reward action learning: a cerebello-basal ganglia theory

Posted by dbos August 25, 2026September 9, 2026Columbia

Kavli Affiliate: Rui Costa | Authors:Michele Garibbo, Carolina Filipe, Laurence Aitchison and Rui Ponte Costa | Summary: Learning depends on both reward- and error-based feedback, yet how the brain integrates these distinct signals to guide behaviour remains fundamentally unclear. Here, using a normative computational framework, we derive credit assignment rules for both reward-based learning (RBL) […]

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SRGAP2 limits experience-dependent structural synaptic plasticity in adult cortical circuits

Posted by dbos August 25, 2026September 9, 2026Columbia

Kavli Affiliate: Franck Polleux | Authors: Sergio Bernal-Garcia, Regina Jiang and Franck Polleux | Summary: In cortical circuits, synaptic plasticity involves either changes in the weight of pre-existing synapses, referred to as functional synaptic plasticity, or synapse formation and elimination, referred to as structural synaptic plasticity. Experience-dependent structural synaptic plasticity is prominent in juvenile cortical […]

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Criterion-selective neurons in the human medial frontal cortex track decision thresholds during memory-based decision making

Posted by dbos August 25, 2026September 9, 2026Hopkins

Kavli Affiliate: Michael Miller | Authors: Evan Layher, Ivan Skelin, Chrystal M Reed, Jeffrey M Chung, Lisa M Bateman, Taufik A Valiante, Adam N Mamelak, Michael B Miller and Ueli Rutishauser | Summary: The decision criterion is foundational to theories of decision-making, yet little is known about its neural underpinnings. In memory-based decision making, the […]

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Discovery and Characterization of the TOI-4468 Planetary System: A Transiting Hot Jupiter With a Lone Nearby Outer Companion

Posted by klaurent August 25, 2026September 9, 2026MIT

Kavli Affiliate: Andrew Vanderburg | Summary:We report the discovery of two planets, a hot Jupiter and a nearby outer sub-Neptune, orbiting the star TOI-4468. This system is unique among the current exoplanet census in that it features a close outer companion to a hot Jupiter without an accompanying inner companion. By jointly fitting radial velocity […]

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Central carbon metabolism switching in lytic versus temperate coral reef viral communities

Posted by dbos August 25, 2026September 9, 2026UCSF

Kavli Affiliate: Robert Edwards | Authors: Jacob Kelman, Meena Khan, Chibundu Umunna, Russell Brainard, Grace Donohue, Robert A Edwards, Natalie A Falta, Emma E. George, Eleanor Gorham, Juris Grasis, Kevin Green, Andreas F Haas, Kimberly Halsey, Eric Hester, Summer Jacob, Aydin Loid Karatas, Yan Wei Lim, Mark Little, Stuart Sandin, Jessie Segnitz, Maya Serota, Natalia […]

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A Beta-Binomial Model for Estimating Zero- or One-inflated Pain Trajectories

Posted by dbos August 25, 2026August 31, 2026Hopkins

Kavli Affiliate: Martin Lindquist | Authors: Yanxi Liu, Richard E. Harris, Daniel Clauw, Emine Bayman, Andrew Leroux and Martin A. Lindquist | Summary: Chronic pain is a widespread public health issue that imposes substantial health, emotional, and economic burdens on individuals and communities. Because pain is subjective and lacks objective biomarkers, it is typically measured […]

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Directional alignment of turn-related activity with locomotor dynamics in the superior colliculus

Posted by dbos August 25, 2026August 31, 2026UCSD / Salk

Kavli Affiliate: Massimo Scanziani and Loren Frank | Authors: Cameron Wilhite, Loren M. Frank and Massimo Scanziani | Summary: Fluid behavior requires temporal coordination across brain systems that orchestrate movement. A clear example is locomotion, in which left and right turns are not only precisely coordinated with the ongoing stepping rhythm but occur at opposite […]

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Low-Frequency Gravitational Bremsstrahlung and Memory in a Medium

Posted by klaurent August 25, 2026September 9, 2026Tokyo

Kavli Affiliate: Hitoshi Murayama | Summary:Gravitational radiation from the early Universe offers a powerful window into physics beyond the Standard Model (SM). In this paper, we investigate the low-frequency tail of gravitational radiation produced by the decay of massive particles. The energy spectrum in Minkowski space-time, $dE/dω$, exhibits two distinct regimes: a flat bremsstrahlung/memory spectrum […]

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