Connectivity Logic of Dendritic Spines in Cortex: Increased Inputs and Ensemble Formation

Posted by dbos Columbia

Kavli Affiliate: Rafael Yuste | Authors: Dean Geckt, Netanel Ofer, Michael W. Reimann, Rafael Yuste and Idan Segev | Summary: Dendritic spines, small protrusions covering the dendrites of most neurons, are fundamental elements of synaptic connectivity, yet their network-level organization remains poorly understood. Here we leverage the large-scale MICrONS volumetric electron microscopy dataset of mouse […]


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Protein Dynamics Beyond Structure Prediction

Posted by klaurent Berkeley

Kavli Affiliate: Carlos Bustamante | Summary:The ability to predict protein three-dimensional structures from amino acid sequences is a landmark achievement in molecular biology, where recent deep learning approaches such as AlphaFold are the culmination of decades of work. Yet, the quantitative understanding of how protein sequences give rise to dynamic conformational changes and higher-order assemblies […]


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Sycophancy Towards Researchers Drives Performative Misalignment

Posted by klaurent MIT

Kavli Affiliate: Max Tegmark | Summary:The increasing situational awareness of language models raises safety concerns: models might be aware when they are evaluated, and adjust their behavior to evade monitoring and resist modification, e.g., pretending to be aligned only in evaluation. This alignment faking behavior is often interpreted as scheming: an intentional effort of strategic […]


Continue.. Sycophancy Towards Researchers Drives Performative Misalignment