Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

Kavli Affiliate: Richard Huganir | Authors: Julia Brill, Blaise Clarke, Ingie Hong and Richard L. Huganir | Summary: SYNGAP1 is a key Ras-GAP protein enriched at excitatory synapses, with mutations causing intellectual disability and epilepsy in humans. Recent studies have revealed that in addition to its role as a negative regulator of G-protein signaling through […]


Continue.. Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility

Convergence of autism proteins at the cilium

Kavli Affiliate: Jeremy Willsey | Authors: Elina Kostyanovskaya, Micaela C. Lasser, Belinda Wang, James Schmidt, Ethel Bader, Chad Buteo, Juan Arbelaez, Aria Rani Sindledecker, Kate E. McCluskey, Octavio Castillo, Sheng Wang, Jeanselle Dea, Kathryn A. Helde, J. Michael Graglia, Elise Brimble, David B. Kastner, Aliza T. Ehrlich, Matthew W. State, A. Jeremy Willsey and Helen […]


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Omics-based insights into human liver reveal GTPase-driven mechanisms of MASLD progression in obesity

Kavli Affiliate: Li Zhao | Authors: Qing Zhao, William de Nardo, Ruoyu Wang, Yi Zhong, Umur Keles, Li Na Zhao, Huiyi Tay, Sonia Youhanna, Mengchao Yan, Ye Xie, Youngrae Kim, Sungdong Lee, Rachel Liyu Lim, Guoshou Teo, Pradeep Naraya, Paul R Burton, Volker M Lauschke, Hyungwon Choi, Matthew J Watt and Philipp Kaldis | Summary: […]


Continue.. Omics-based insights into human liver reveal GTPase-driven mechanisms of MASLD progression in obesity

LayerAnimate: Layer-specific Control for Animation

Kavli Affiliate: Feng Wang | First 5 Authors: Yuxue Yang, Lue Fan, Zuzeng Lin, Feng Wang, Zhaoxiang Zhang | Summary: Animated video separates foreground and background elements into layers, with distinct processes for sketching, refining, coloring, and in-betweening. Existing video generation methods typically treat animation as a monolithic data domain, lacking fine-grained control over individual […]


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Resolving Structural Origins for Superconductivity in Strain-Engineered La$_3$Ni$_2$O$_7$ Thin Films

Kavli Affiliate: David A. Muller | First 5 Authors: Lopa Bhatt, Abigail Y. Jiang, Eun Kyo Ko, Noah Schnitzer, Grace A. Pan | Summary: The discovery of high-temperature superconductivity in bulk La$_3$Ni$_2$O$_7$ under high hydrostatic pressure and, more recently, biaxial compression in epitaxial thin films has ignited significant interest in understanding the interplay between atomic […]


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Superconductivity and normal-state transport in compressively strained La$_2$PrNi$_2$O$_7$ thin films

Kavli Affiliate: David A. Muller | First 5 Authors: Yidi Liu, Eun Kyo Ko, Yaoju Tarn, Lopa Bhatt, Berit H. Goodge | Summary: The discovery of superconductivity under high pressure in Ruddlesden-Popper phases of bulk nickelates has sparked great interest in stabilizing ambient pressure superconductivity in thin-film form using epitaxial strain. Recently, signs of superconductivity […]


Continue.. Superconductivity and normal-state transport in compressively strained La$_2$PrNi$_2$O$_7$ thin films

Roadmap on Neuromorphic Photonics

Kavli Affiliate: Alireza Marandi | First 5 Authors: Daniel Brunner, Bhavin J. Shastri, Mohammed A. Al Qadasi, H. Ballani, Sylvain Barbay | Summary: This roadmap consolidates recent advances while exploring emerging applications, reflecting the remarkable diversity of hardware platforms, neuromorphic concepts, and implementation philosophies reported in the field. It emphasizes the critical role of cross-disciplinary […]


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Roadmap on Neuromorphic Photonics

Kavli Affiliate: Alireza Marandi | First 5 Authors: Daniel Brunner, Bhavin J. Shastri, Mohammed A. Al Qadasi, H. Ballani, Sylvain Barbay | Summary: This roadmap consolidates recent advances while exploring emerging applications, reflecting the remarkable diversity of hardware platforms, neuromorphic concepts, and implementation philosophies reported in the field. It emphasizes the critical role of cross-disciplinary […]


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Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischemic stroke

Kavli Affiliate: John Reynolds | Authors: Emily S King, Jamie L Beros, Hakuei Fujiyama, John N Reynolds and Alexander D Tang | Summary: Background: Stroke is a leading cause of disability and stroke-induced changes in cortical excitability are thought to impede functional recovery. Identifying cellular targets that contribute to maladaptive excitability holds great potential for […]


Continue.. Characterisation of the axon initial segment and intrinsic excitability in the sub-acute phase post-ischemic stroke

Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death

Kavli Affiliate: Shai Shaham | Authors: Rashna Sharmin, Aladin Elkhalil, Sara Pena, Pranya Gaddipati, Ginger Clark, Pavak K Shah, Mark W Pellegrino, Shai Shaham and Piya Ghose | Summary: Polarized cells (such as neurons), defined by distinct compartments are, like many cell types, subject to developmental elimination, as in neurite pruning. The molecular mechanism behind […]


Continue.. Mitochondria transported by Kinesin 3 prevent localized calcium spiking to inhibit caspase-dependent specialized cell death