A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Posted by dbos Columbia, This Week: Neuroscience

Kavli Affiliate: Rafael Yuste | Authors: Kengo Takahashi, Gerhardus Jan Huis in ‘t Veld, Davide Benedetti, Jun-Ying Wang, Samuel Pontes Quero, Rafael Yuste, Cyriel M.A. Pennartz and Umberto Olcese | Summary: Many techniques to record and manipulate neuronal activity across large portions of the vertebrate brain, such as widefield and two-photon calcium imaging, electrophysiology, and […]


Continue.. A polymeric, PDMS-based large-scale skull replacement suitable for optical and mechanical access for long-term neuronal imaging, electrophysiology, and optogenetics

Fast and accessible morphology-free functional fluorescence imaging analysis

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Kishore V. Kuchibhotla and Adam S. Charles | Authors: Alejandro A Estrada Berlanga, Gabrielle Kang, Amanda Kwok, Thomas Broggini, Jennifer Lawlor, Kishore Kuchibhotla, David Kleninfeld, Gal Mishne and Adam Charles | Summary: Optical calcium imaging is a powerful tool for recording neural activity across a wide range of spatial scales, from dendrites and […]


Continue.. Fast and accessible morphology-free functional fluorescence imaging analysis

Survey of hippocampal responses to sound in naive mice reveals widespread activation by broadband noise onsets

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Andrea Hasenstaub | Authors: James Bigelow, Toshiaki Suzuki, Yulang Wu, Ying Hu and Andrea R Hasenstaub | Summary: Recent studies suggest some hippocampal (HC) neurons respond to passively presented sounds in naive subjects, but the specificity and prevalence of these responses remain unclear. We used Neuropixels probes to record unit activity in HC […]


Continue.. Survey of hippocampal responses to sound in naive mice reveals widespread activation by broadband noise onsets

D3 dopamine receptors implicate a subtype of medium spiny neuron in the aversive effects of antipsychotic medications

Posted by dbos This Week: Neuroscience, UCSF

Kavli Affiliate: Kevin Bender | Authors: Elinor Lewis, Jessie Muir, Ling C Li, Julianna Glienke, Sarah Warren Gooding, Kevin Bender, Christina Kim and Jennifer Whistler | Summary: Second generation antipsychotics (SGAs) are widely used clinical tools, yet they often cause negative side effects and take weeks to become effective, leading to poor patient compliance. The […]


Continue.. D3 dopamine receptors implicate a subtype of medium spiny neuron in the aversive effects of antipsychotic medications