Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

Kavli Affiliate: Stanley Prusiner | Authors: Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E. Merz, Stanley B. Prusiner, Daniel R. Southworth and Carlo Condello | Summary: Down Syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, […]


Continue.. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Kavli Affiliate: Denis Wirtz | Authors: Ashleigh J Crawford, Adrian Johnston, Wenxuan Du, Eban A Hanna, David Schell, Zeqi Wan, Ting-Hsi Chen, Fan Wu, Kehan Ren, Yeongseo Lim, Praful R Nair and Denis Wirtz | Summary: Immune cell-mediated killing of cancer cells in a solid tumor is prefaced by a multi-step infiltration cascade of invasion, […]


Continue.. A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

Angular dependence in transverse momentum dependent diffractive parton distributions at small-$x$

Kavli Affiliate: Feng Yuan | First 5 Authors: Yoshitaka Hatta, Feng Yuan, , , | Summary: We discuss the angular dependence of the recently proposed transverse momentum dependent quark and gluon diffractive parton distributions at small-$x$. We introduce the difractive versions of the Sivers function and the elliptic gluon Wigner distribution and evaluate them in […]


Continue.. Angular dependence in transverse momentum dependent diffractive parton distributions at small-$x$

Coherent control from quantum committment probabilities

Kavli Affiliate: David T. Limmer | First 5 Authors: Michelle C. Anderson, Amro Dodin, Thomas P. Fay, David T. Limmer, | Summary: We introduce a general definition of a quantum committor in order to clarify reaction mechanisms and facilitate control in processes where coherent effects are important. With a quantum committor, we generalize the notion […]


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Small extracellular vesicles promote stiffness-mediated metastasis

Kavli Affiliate: Denis Wirtz | Authors: Alexandra Sneider, Ying Liu, Bartholomew Starich, Wenxuan Du, Carolyn Marar, Najwa Faqih, Gabrielle E Ciotti, Joo Ho Kim, Sejal Krishnan, Salma Ibrahim, Muna Igboko, Alexus Locke, Daniel M Lewis, Hanna Hong, Michelle Karl, Raghav Vij, Gabriella C Russo, Praful R Nair, Estibaliz Gómez-de-Mariscal, Mehran Habibi, Arrate Munoz-Barrutia, Luo Gu, […]


Continue.. Small extracellular vesicles promote stiffness-mediated metastasis

AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

Kavli Affiliate: Mark Ellisman | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia activation is accompanied by the formation and chronic maintenance of TLR4 inflammarafts, defined as enlarged and cholesterol-rich lipid rafts serving as an assembly platform […]


Continue.. AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer′s disease

A Novel Dual Probe-based Method for Mutation Detection using Isothermal Amplification

Kavli Affiliate: Michael Miller | Authors: Nidhi Nandu, Michael Miller, Yanhong Tong and Zhi-xiang Lu | Summary: Cost efficient and rapid detection tools to detect mutations especially those linked to drug-resistance are important to address concerns of the rising multi-drug resistance infections. Here we integrated dual probes, namely a calibrator probe and an indicator probe, […]


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Evaluation of transition rates from nonequilibrium instantons

Kavli Affiliate: David T. Limmer | First 5 Authors: Eric R. Heller, David T. Limmer, , , | Summary: Equilibrium rate theories play a crucial role in understanding rare, reactive events. However, they are inapplicable to a range of irreversible processes in systems driven far from thermodynamic equilibrium like active and biological matter. Here, we […]


Continue.. Evaluation of transition rates from nonequilibrium instantons