Integrating gene expression and imaging data across Visium capture areas with visiumStitched

Posted by dbos Hopkins

Kavli Affiliate: Keri Martinowich | Authors: Nicholas J. Eagles, Svitlana V. Bach, Madhavi Tippani, Prashanti Ravichandran, Yufeng Du, Ryan A. Miller, Thomas Hyde, Stephanie C. Page, Keri Martinowich and Leonardo Collado-Torres | Summary: Background Visium is a widely-used spatially-resolved transcriptomics assay available from 10x Genomics. Standard Visium capture areas (6.5mm by 6.5mm) limit the survey […]


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Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity

Posted by dbos UCSF

Kavli Affiliate: Kevin Bender | Authors: Ryan Alexander and Kevin Bender | Summary: Opioids regulate circuits associated with motivation and reward across the brain. Of the opioid receptor types, delta opioid receptors (DORs) appear to have a unique role in regulating the activity of circuits related to reward without a liability for abuse. In neocortex, […]


Continue.. Delta opioid receptors engage multiple signaling cascades to differentially modulate prefrontal GABA release with input and target specificity

Proof of principle X-ray reflection mass measurement of the black hole in H1743-322

Posted by dbos MIT

Kavli Affiliate: Erin Kara | First 5 Authors: Edward Nathan, Adam Ingram, James F. Steiner, Ole König, Thomas Dauser | Summary: The black hole X-ray binary H1743-322 lies in a region of the Galaxy with high extinction, and therefore it has not been possible to make a dynamical mass measurement. In this paper we make […]


Continue.. Proof of principle X-ray reflection mass measurement of the black hole in H1743-322

Absence of High-mass Prestellar Cores in the Orion Giant Molecular Cloud

Posted by dbos Peking

Kavli Affiliate: Ke Wang | First 5 Authors: Wenyu Jiao, Ke Wang, Fengwei Xu, , | Summary: A fundamental difference between "core-fed" and "clump-fed" star formation theories lies in the existence or absence of high-mass cores at the prestellar stage. However, only a handful of such cores have been observed. Here, different than previous search […]


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Correlators of $mathcal{N}=4$ SYM on real projective space at strong coupling

Posted by dbos UCAS

Kavli Affiliate: Xinan Zhou | First 5 Authors: Xinan Zhou, , , , | Summary: We consider type IIB supergravity on a $mathbb{Z}_2$ quotient of AdS$_5times$S$^5$ as the holographic dual of strongly coupled 4d $mathcal{N}=4$ SYM on $mathbb{RP}^4$ space with the gauging of charge conjugation. Using bootstrap techniques, we determine all two-point functions of $frac{1}{2}$-BPS […]


Continue.. Correlators of $mathcal{N}=4$ SYM on real projective space at strong coupling