Covalent Targeting of Splicing in T Cells.

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab and Ekaterina V Vinogradova | Summary: Despite significant interest in therapeutic targeting of splicing, few chemical probes […]


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An outburst and FU Ori-type disk of a former low luminosity protostar

Kavli Affiliate: Gregory J. Herczeg | First 5 Authors: Mizna Ashraf, Jessy Jose, Ho-Gyu Lee, Carlos Contreras Peña, Gregory J Herczeg | Summary: Strong accretion outbursts onto protostars are associated with emission dominated by a viscously heated disk, which is characterized by high luminosities. We report the discovery and characterization of a strong mid-IR (3.4, […]


Continue.. An outburst and FU Ori-type disk of a former low luminosity protostar

An outburst and FU Ori-type disk of a former low luminosity protostar

Kavli Affiliate: Gregory Herczeg | First 5 Authors: Mizna Ashraf, Jessy Jose, Ho-Gyu Lee, Carlos Contreras Peña, Gregory Herczeg | Summary: Strong accretion outbursts onto protostars are associated with emission dominated by a viscously heated disk, which is characterized by high luminosities. We report the discovery and characterization of a strong mid-IR (3.4, 4.6 $mu$m) […]


Continue.. An outburst and FU Ori-type disk of a former low luminosity protostar

MM-TTS: Multi-modal Prompt based Style Transfer for Expressive Text-to-Speech Synthesis

Kavli Affiliate: Feng Wang | First 5 Authors: Wenhao Guan, Yishuang Li, Tao Li, Hukai Huang, Feng Wang | Summary: The style transfer task in Text-to-Speech refers to the process of transferring style information into text content to generate corresponding speech with a specific style. However, most existing style transfer approaches are either based on […]


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Spool-nematic ordering of dsDNA and dsRNA under confinement

Kavli Affiliate: Rudolf Podgornik | First 5 Authors: James Farrell, Jure Dobnikar, Rudolf Podgornik, Tine Curk, | Summary: The ability of double-stranded DNA or RNA to locally melt and form kinks leads to strong non-linear elasticity effects that qualitatively affect their packing in confined spaces. Using analytical theory and numerical simulation we show that kink […]


Continue.. Spool-nematic ordering of dsDNA and dsRNA under confinement

Spool-nematic ordering of dsDNA and dsRNA under confinement

Kavli Affiliate: Rudolf Podgornik | First 5 Authors: James Farrell, Jure Dobnikar, Rudolf Podgornik, Tine Curk, | Summary: The ability of double-stranded DNA or RNA to locally melt and form kinks leads to strong non-linear elasticity effects that qualitatively affect their packing in confined spaces. Using analytical theory and numerical simulation we show that kink […]


Continue.. Spool-nematic ordering of dsDNA and dsRNA under confinement

Spool-nematic ordering of dsDNA and dsRNA under confinement

Kavli Affiliate: Rudolf Podgornik | First 5 Authors: James Farrell, Jure Dobnikar, Rudolf Podgornik, Tine Curk, | Summary: The ability of double-stranded DNA or RNA to locally melt and form kinks leads to strong non-linear elasticity effects that qualitatively affect their packing in confined spaces. Using analytical theory and numerical simulation we show that kink […]


Continue.. Spool-nematic ordering of dsDNA and dsRNA under confinement

Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

Kavli Affiliate: Shawn Ferguson | Authors: Gabriel Talaia, Amanda Bentley-DeSousa and Shawn Ferguson | Summary: Lysosomes play a pivotal role in coordinating macromolecule degradation and regulating cell growth and metabolism. Despite substantial progress in identifying lysosomal signaling proteins, understanding the pathways that synchronize lysosome functions with changing cellular demands remains incomplete. This study uncovers a […]


Continue.. Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

Kavli Affiliate: V. S. Ramachandran | Authors: B.R. Ansil, Ashwin Viswanathan, Vivek Ramachandran, H.M. Yeshwanth, Avirup Sanyal and Uma Ramakrishnan | Summary: Small mammals and their ectoparasites present a unique system to investigate the eco-epidemiology of multi-host vector-borne pathogens and identify specific bacterial spillover determinants. We applied ecological and evolutionary analyses in a rainforest-human-use mosaic […]


Continue.. Host–pathogen–vector continuum in a changing landscape: Drivers of Bartonella prevalence and evidence of historic spillover in a multi–host community

VecFusion: Vector Font Generation with Diffusion

Kavli Affiliate: Matthew Fisher | First 5 Authors: Vikas Thamizharasan, Difan Liu, Shantanu Agarwal, Matthew Fisher, Michael Gharbi | Summary: We present VecFusion, a new neural architecture that can generate vector fonts with varying topological structures and precise control point positions. Our approach is a cascaded diffusion model which consists of a raster diffusion model […]


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