Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Kavli Affiliate: Jean Fan | Authors: Rafael dos Santos Peixoto, Brendan F Miller, Maigan A Brusko, Lyla Atta, Manjari Anant, Mark A Atkinson, Todd M Brusko, Clive H Wasserfall and Jean Fan | Summary: Spatially resolved omics technologies provide molecular profiling of cells while preserving their organization within tissues, allowing for the evaluation of cell-type […]


Continue.. Characterizing cell-type spatial relationships across length scales in spatially resolved omics data

Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Kavli Affiliate: Michael Beer | Authors: Jin Woo Oh and Michael A Beer | Summary: Gene regulatory elements drive many complex biological phenomena such as fetal development, and their mutations are linked to a multitude of common human diseases. The phenotypic impacts of regulatory variants are often tested using their conserved orthologous counterparts in model […]


Continue.. Gapped-kmer sequence modeling robustly identifies regulatory vocabularies and distal enhancers conserved between evolutionarily distant mammals

Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Kavli Affiliate: Michael J Higley | Authors: Samantha Bottom-Tanzer, Sofia Corella, Jochen Meyer, Mary Sommer, Luis Bolanos, Timothy Murphy, Sadi Quinones, Shane Heiney, Matthew Shtrahman, Michael Whalen, Rachel Oren, Michael J Higley, Jessica A Cardin, Farzad Noubary, Moritz Armbruster and Chris Dulla | Summary: Traumatic brain injury (TBI) is the leading cause of death in […]


Continue.. Traumatic brain injury disrupts state-dependent functional cortical connectivity in a mouse model

Robust cosmological inference from non-linear scales with k-th nearest neighbor statistics

Kavli Affiliate: Tom Abel | First 5 Authors: Sihan Yuan, Tom Abel, Risa H. Wechsler, , | Summary: We present the methodology for deriving accurate and reliable cosmological constraints from non-linear scales (<50Mpc/h) with k-th nearest neighbor (kNN) statistics. We detail our methods for choosing robust minimum scale cuts and validating galaxy-halo connection models. Using […]


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Exploring chemical enrichment of the intracluster medium with the Line Emission Mapper

Kavli Affiliate: Mark Vogelsberger | First 5 Authors: François Mernier, Yuanyuan Su, Maxim Markevitch, Congyao Zhang, Aurora Simionescu | Summary: Synthesized in the cores of stars and supernovae, most metals disperse over cosmic scales and are ultimately deposited well outside the gravitational potential of their host galaxies. Since their presence is well visible through their […]


Continue.. Exploring chemical enrichment of the intracluster medium with the Line Emission Mapper