Kavli Affiliate: Seth Shipman | Authors: Kate D. Crawford, Asim G. Khan, Santiago C. Lopez, Hani Goodarzi and Seth Shipman | Summary: The bacterial retron reverse transcriptase system has served as an intracellular factory for single-stranded DNA in many biotechnological applications. In these technologies, a natural retron non-coding RNA (ncRNA) is modified to encode a […]
Continue.. High Throughput Variant Libraries and Machine Learning Yield Design Rules for Retron Gene Editors