Kavli Affiliate: Philip Starr | Authors: Jin-Xiao Zhang, Clay Smyth, Md Fahim Anjum, Yue Leng, Andrew D. Krystal, Philip A. Starr and Simon Little | Summary: Sleep disturbance is involved in the progression of neurodegenerative diseases, but the neurophysiological mechanisms remain unclear in humans. We recorded sleep at home using portable polysomnography for multiple nights […]
Kavli Affiliate: Noelle L’Etoile and Saul Kato | Authors: Raymond L Dunn, Caitriona Costello, Jackson M Borchardt, Daniel Yutaka Sprague, Grace C Chiu, Julia M Miller, Noelle L’Etoile and Saul Kato | Summary: Working memory allows an animal to gather sensory evidence over time, integrate it with evolving internal needs, and make informed decisions about […]
Kavli Affiliate: Pietro De Camilli | Authors: Peng Xu, Rubia Isler Mancuso, Marianna Leonzino, Caroline J Zeiss, Diane S Krause and Pietro De Camilli | Summary: VPS13 is the founding member of a family of proteins that mediate lipid transfer at intracellular membrane contact sites by a bridge-like mechanism. Mammalian genomes comprise 4 VPS13 genes […]
Kavli Affiliate: Hitoshi Murayama | First 5 Authors: Tony Gherghetta, Hitoshi Murayama, Pablo Quílez, , | Summary: We present a composite QCD axion model where the Peccei–Quinn (PQ) symmetry emerges as a high-quality, accidental symmetry. The axion potential is only modified by eight-fermion, dimension 12 operators, which if present at the Planck scale, allow for […]
Kavli Affiliate: Dan Luo | First 5 Authors: Dan Luo, Jinyu Zhou, Le Xu, Sisi Yuan, Xuan Lin | Summary: Predicting drug-target binding affinity (DTA) is essential for identifying potential therapeutic candidates in drug discovery. However, most existing models rely heavily on static protein structures, often overlooking the dynamic nature of proteins, which is crucial […]
Kavli Affiliate: Tom Melia | First 5 Authors: David E. Kaplan, Tom Melia, Surjeet Rajendran, , | Summary: Three possible strategies have been advocated to solve the strong CP problem. The first is the axion, a dynamical mechanism that relaxes any initial value of the CP violating angle $bar{theta}$ to zero. The second is the […]
Kavli Affiliate: Claudio Ricci | First 5 Authors: Alessandro Peca, Michael J. Koss, Roberto Serafinelli, Claudio Ricci, C. Megan Urry | Summary: We report the serendipitous discovery of an absorption feature at 4.8 keV in the NuSTAR spectra of ESP 39607, a Seyfert 2 galaxy at $z = 0.201$, observed in May 2023 and August […]
Kavli Affiliate: Charles M. Rice | Authors: Matthew A Cattle, Lauren C Aguado, Samantha Sze, Dylan Yueyang Wang, Thales Papagiannakopoulos, Susan Smith, Charles M Rice, William Matthew Schneider and John T Poirier | Summary: Retrons are a retroelement class found in diverse prokaryotes that can be adapted to augment CRISPR-Cas9 genome engineering technology to efficiently […]
Kavli Affiliate: Yuji Tachikawa | First 5 Authors: Saghar S. Hosseini, Yuji Tachikawa, Hao Y. Zhang, , | Summary: We revisit the issue of how the perturbative and global fermion anomaly of Type I string theory in ten dimensions is cancelled by the Green-Schwarz mechanism using the RR fields. This will be done by realising […]