The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

Kavli Affiliate: Li Zhao | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sayal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


Continue.. The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain

C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain

Kavli Affiliate: Yishi Jin | Authors: Yishi Jin, Stephan M Blazie, Daniel Fortunati and Yan Zhao | Summary: Protein translation initiation is a complex and conserved process involving many proteins acting in concert. The eukaryotic initiation factor 3 (eIF3) complex is essential for the assembly of the pre-initiation complex that scans and positions mRNA at […]


Continue.. C. elegans LIN-66 mediates EIF-3.G-dependent protein translation via a cold-shock domain

Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection

Kavli Affiliate: Sreekanth Chalasani | Authors: Nadia B Haghani, Robert H Lampe, Buck Samuel, Sreekanth H Chalasani and Molly A Matty | Summary: In the wild, C. elegans are emersed in environments teeming with a veritable menagerie of microorganisms. The C. elegans cuticular surface serves as a barrier and first point of contact with this […]


Continue.. Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection

AIBP controls amyloid beta induced TLR4 inflammarafts and mitochondrial dysfunction in microglia

Kavli Affiliate: Mark Ellisman | Authors: Yi Sak Kim, SOO-HO CHOI, Keun-Young Kim, Juliana M Navia Pelaez, Guy A Perkins, Seunghwan Choi, Nicolaus Nazarenkov Miller, Jungsu Kim, Wonkyu Ju, Robert A Rissman, Mark H Ellisman and Yury I Miller | Summary: Microglia-driven neuroinflammation plays an important role in the development of Alzheimer’s disease (AD). Microglia […]


Continue.. AIBP controls amyloid beta induced TLR4 inflammarafts and mitochondrial dysfunction in microglia

Predictive Sequence Learning in the Hippocampal Formation

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang, Mia Cameron and Terrence J Sejnowski | Summary: The hippocampus receives sequences of sensory inputs from the cortex during exploration and encodes the sequences with millisecond precision. We developed a predictive autoencoder model of the hippocampus including the trisynaptic and monosynaptic circuits from the entorhinal […]


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A spatial model of autophosphorylation of CaMKII in a glutamatergic spine suggests a network-driven kinetic mechanism for bistable changes in synaptic strength

Kavli Affiliate: Terrence Sejnowski | Authors: Thomas M Bartol, Mariam Ordyan, Terrence J Sejnowski, Padmini Rangamani and Mary B. Kennedy | Summary: Activation of N-methyl-D-aspartate-type glutamate receptors (NMDARs) at synapses in the CNS triggers changes in synaptic strength that underlie memory formation in response to strong synaptic stimuli. The primary target of Ca2+ flowing through […]


Continue.. A spatial model of autophosphorylation of CaMKII in a glutamatergic spine suggests a network-driven kinetic mechanism for bistable changes in synaptic strength

CellBoost: A pipeline for machine assisted annotation in neuroanatomy

Kavli Affiliate: David Kleinfeld | Authors: Kui Qian, Beth Friedman, Jun Takatoh, Fan Wang, David Kleinfeld and Yoav Freund | Summary: One of the important yet labor intensive tasks in neuroanatomy is the identification of select populations of cells. Current high-throughput techniques enable marking cells with histochemical fluorescent molecules as well as through the genetic […]


Continue.. CellBoost: A pipeline for machine assisted annotation in neuroanatomy

Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis

Kavli Affiliate: Anders Dale | Authors: Atle Eskeland Rimehaug, Anders M. Dale, Anton Arkhipov and Gaute T. Einevoll | Summary: The local field potential (LFP), the low-frequency part of the extracellular potential, reflects transmembrane currents in the vicinity of the recording electrode. Thought mainly to stem from currents caused by synaptic input, it provides information […]


Continue.. Uncovering population contributions to the extracellular potential in the mouse visual system using Laminar Population Analysis

Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus

Kavli Affiliate: Terrence Sejnowski | Authors: Dana E Cobb-Lewis, Anne George, Shannon Hu, Katherine Packard, Mingyuan Song, Oliver Nguyen-Lopez, Emily Ikematsu Tesone, Jhanay Rowden, Julie Wang and Maya Opendak | Summary: Long-term potentiation (LTP) has become a standard model for investigating synaptic mechanisms of learning and memory. Increasingly, it is of interest to understand how […]


Continue.. Long-Term Potentiation Produces a Sustained Expansion of Synaptic Information Storage Capacity in Adult Rat Hippocampus