Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Samuel J L Gascoigne, Andre Tavares Correia Dias, Maja Kajin and Rob Salguero-Gomez | Summary: The Demographic Buffering Hypothesis (DBH) predicts that natural selection reduces the temporal fluctuations in demographic processes (such as survival, development, and reproduction), due to their negative impacts on population dynamics. However, […]
Kavli Affiliate: Dhakshin Ramanathan | Authors: Miranda Francoeur Koloski, Christopher M O’Hearn, Michelle Frankot, Lauren P Giesler, Dhakshin S Ramanathan and Cole Vonder Haar | Summary: Traumatic brain injury (TBI) affects a large population, resulting in severe cognitive impairments. Although cognitive rehabilitation is an accepted treatment for some deficits, studies in patients are limited in […]
Kavli Affiliate: Timothy Brown | Authors: Kristian Davidsen, Jonathan S Marvin, Abhi Aggarwal, Timothy A Brown and Lucas B Sullivan | Summary: Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure aspartate abundance. However, […]
Kavli Affiliate: Timothy Brown, Anders Dale | Authors: Carolina Makowski, Timothy T Brown, Weiqi Zhao, Donald J Hagler, Pravesh Parekh, Hugh Garavan, Thomas E Nichols, Terry L Jernigan and Anders M Dale | Summary: Magnetic resonance imaging (MRI) has been a popular and useful non-invasive method to map patterns of brain structure and function to […]
Kavli Affiliate: Timothy Brown | Authors: Boaz Mohar, Jonathan B. Grimm, Ronak Patel, Timothy A. Brown, Paul Tillberg, Luke D. Lavis, Nelson Spruston and Karel Svoboda | Summary: Cellular functions are regulated by synthesizing and degrading proteins on time scales ranging from minutes to weeks. Protein turnover varies across proteins, cellular compartments, cell types, and […]
Kavli Affiliate: Terrence Sejnowski | Authors: Nuttida Rungratsameetaweemana, Robert Kim, Thiparat Chotibut and Terrence Sejnowski | Summary: Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neurons perform cognitive tasks. Training such networks to perform tasks that require information maintenance over a brief […]
Kavli Affiliate: Cory Miller | Authors: Timothy Tyree, Michael Metke and Cory Miller | Summary: Faces and voices are the dominant social signals used to recognize individuals amongst human and nonhuman primates (1–4). Yet it is not known how these critical signals are integrated into a cross-modal representation of individual identity in the primate brain. […]
Kavli Affiliate: Mark Ellisman | Authors: Yaeram Jeong, chung-ha Davis, Aaron Muscarella, Viraj Deshpande, Keun-Young Kim, Mark Ellisman and Nicholas Marsh-Armstrong | Summary: We previously described a process referred to as transmitophagy where mitochondria shed by retinal ganglion cell (RGC) axons are transferred to and degraded by surrounding astrocytes in the optic nerve head of […]
Kavli Affiliate: Mark Ellisman | Authors: George A. Spirou, Matthew Kersting, Sean Carr, Bayan Razzaq, Carolyna Y. Alves-Pinto, Mariah Dawson, Mark H. Ellisman and Paul B. Manis | Summary: Globular bushy cells (GBCs) of the cochlear nucleus play central roles in the temporal processing of sound. Despite investigation over many decades, fundamental questions remain about […]
Kavli Affiliate: John Reynolds | Authors: Courtney Glavis-Bloom, Casey R Vanderlip, Payton A Asch and John H Reynolds | Summary: Age-related cognitive impairment is not expressed uniformly across cognitive domains. Cognitive functions that rely on brain areas that undergo substantial neuroanatomical changes with age often show age-related impairment, while those that rely on brain areas […]