Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

Kavli Affiliate: Eiman Azim | Authors: Jake Lustig, Alexander Lammers, Julia Kaiser, Payal Patel, Aidan Raghu, James M. Conner, Phong Nguyen, Eiman Azim and Vibhu Sahni | Summary: The corticospinal tract (CST) facilitates skilled, precise movements, which necessitates that subcerebral projection neurons (SCPN) establish segmentally specific connectivity with brainstem and spinal circuits. Developmental molecular delineation […]


Continue.. Selective Targeting of a Defined Subpopulation of Corticospinal Neurons using a Novel Klhl14-Cre Mouse Line Enables Molecular and Anatomical Investigations through Development into Maturity

A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Kavli Affiliate: John Serences | Authors: Anna Shafer-Skelton, Timothy F Brady and John T Serences | Summary: Understanding 3D representations of spatial information, particularly in naturalistic scenes, remains a significant challenge in vision science. This is largely because of conceptual difficulties in disentangling higher-level 3D information from co-occurring features and cues (e.g., the 3D shape […]


Continue.. A 2D Gabor-wavelet baseline model out-performs a 3D surface model in scene-responsive cortex

Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

Kavli Affiliate: Yishi Jin | Authors: Erin M Ritchie, Siming Zhong, Qianyi Pu, Yunbo Li, Binhai Zheng and Yishi Jin | Summary: The conserved MAP3K12/Dual Leucine Zipper Kinase (DLK) plays versatile roles in neuronal development, axon injury and stress responses, and neurodegeneration, depending on cell-type and cellular contexts. Emerging evidence implicates abnormal DLK signaling in […]


Continue.. Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration

How much is ‘enough’? Considerations for functional connectivity reliability in pediatric naturalistic fMRI

Kavli Affiliate: Deanna J. Greene and Jeremy Willsey | Authors: Shefali S. Rai, Kate J. Godfrey, Kirk Graff, Ryann Tansey, Daria Merrikh, Shelly Yin, Matthew Feigelis, Damion V. Demeter, Tamara Vanderwal, Deanna J. Greene and Signe L. Bray | Summary: functional connectivity (FC) measurements are important for robust and reproducible findings, yet pediatric functional magnetic […]


Continue.. How much is ‘enough’? Considerations for functional connectivity reliability in pediatric naturalistic fMRI

Active vision in freely moving marmosets using head-mounted eye tracking

Kavli Affiliate: Cory Miller | Authors: Vikram Pal Singh, Jingwen Li, Jude Mitchell and Cory Miller | Summary: Our understanding of how vision functions as primates actively navigate the real-world is remarkably sparse. As most data have been limited to chaired and typically head-restrained animals, the synergistic interactions of different motor actions/plans inherent to active […]


Continue.. Active vision in freely moving marmosets using head-mounted eye tracking

Inter- and Intrahemispheric Sources of Vestibular Signals to V1

Kavli Affiliate: Massimo Scanziani | Authors: Guy Bouvier, Alessandro Sanzeni, Elizabeth Hamada, Nicolas Brunel and Massimo Scanziani | Summary: Head movements are sensed by the vestibular organs. Unlike classical senses, signals from vestibular organs are not conveyed to a dedicated cortical area but are broadcast throughout the cortex. Surprisingly, the routes taken by vestibular signals […]


Continue.. Inter- and Intrahemispheric Sources of Vestibular Signals to V1

Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Kavli Affiliate: Gabriel Silva | Authors: Jeziel D Damasceno, Gabriel LA Silva, Catarina A Marques, Marija Krasilnikova, Craig Lapsley, Dario Beraldi and Richard McCulloch | Summary: Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from population-based techniques, with only […]


Continue.. Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events

Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila

Kavli Affiliate: Mark Ellisman | Authors: Francisco Joaquín Tassara, Mariano Barella, Lourdes Simó, Mailen Folgueira, Micaela Rodríguez-Caron, Juan Ignacio Ispizua, Mark H. Ellisman, Horacio O. de la Iglesia, M. Fernanda Ceriani and Julián Gargiulo | Summary: In vivo imaging of dynamic sub-cellular brain structures in Drosophila melanogaster is key to understanding several phenomena in neuroscience. […]


Continue.. Single Objective Light Sheet Microscopy allows high-resolution in vivo brain imaging of Drosophila

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Kavli Affiliate: Mark Ellisman | Authors: Song-Yi Lee, Heegwang Roh, David Gonzalez-Perez, Mason R Mackey, Keun-Young Kim, Daniel Hoces, Colleen McLaughlin, Stephen R Adams, Khanh Nguyen, David J Luginbuhl, Liqun Luo, Namrata Udeshi, Steven A Carr, Rogelio A Hernandez-Lopez, Mark Ellisman, Miguel Alcalde and Alice Y Ting | Summary: Enzymes that oxidize aromatic substrates have […]


Continue.. Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Discovering Cognitive Strategies with Tiny Recurrent Neural Networks

Kavli Affiliate: Marcelo Mattar | Authors: Li Ji-An, Marcus K Benna and Marcelo G Mattar | Summary: Normative modeling frameworks such as Bayesian inference and reinforcement learning provide valuable insights into the fundamental principles governing adaptive behavior. While these frameworks are valued for their simplicity and interpretability, their reliance on few parameters often limits their […]


Continue.. Discovering Cognitive Strategies with Tiny Recurrent Neural Networks