Brain-wide Correspondence Between Neuronal Epigenomics and Long-Distance Projections

Kavli Affiliate: Edward Callaway | Authors: Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Angeline C. Rivkin, Will N. Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew I. Aldridge, Qiurui Zeng, J.L. Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Jordan […]


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FEMA: Fast and efficient mixed-effects algorithm for large sample whole-brain imaging data

Kavli Affiliate: Wesley Thompson, Anders Dale | Authors: Pravesh Parekh, Chun Chieh Fan, Oleksandr Frei, Clare E Palmer, Diana M. Smith, Carolina Makowski, John Iverson, Diliana Pecheva, Dominic Holland, Robert Loughnan, Pierre Nedelec, Wesley K Thompson, Donald J. Hagler, Jr., Ole A. Andreassen, Terry L Jernigan, Thomas Nichols and Anders M. Dale | Summary: The […]


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TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

Kavli Affiliate: Mark Ellisman | Authors: Sumin Kim, Sebastien Phan, Thomas R Shaw, Mark H Ellisman, Sarah L Veatch, Sami J Barmada, Samuel S Pappas and William T Dauer | Summary: Nuclear pore complexes (NPCs) regulate information transfer between the nucleus and cytoplasm. NPC defects are linked to several neurological diseases, but the processes governing […]


Continue.. TorsinA is essential for the timing and localization of neuronal nuclear pore complex biogenesis

The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Kavli Affiliate: Angela Yu | Authors: Liang Liu, Angela M Yu, Xiuye Wang, Lindsey V. Soles, Yiling Chen, Yoseop Yoon, Kristianna S.K. Sarkan, Marielle Cárdenas Valdez, Johannes Linder, Ivan Marazzi, Zhaoxia Yu, Feng Qiao, Wei Li, Georg Seelig and Yongsheng Shi | Summary: JTE-607 is a small molecule compound with anti-inflammation and anti-cancer activities. Upon […]


Continue.. The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery

Do perineuronal nets stabilize the engram of a synaptic circuit?

Kavli Affiliate: Mark Ellisman | Authors: Varda Lev-Ram, Sakina Palida, Thomas J Deerinck, Eric A Bushong, Brandon H Toyoma, Alex Perez, Daniel B McClatchy, Denise R Prichard, Jeffrey N Savas, Mark H Ellisman, John Robert Yates III and Roger Y Tsien | Summary: Perineuronal nets (PNN), a specialized form of ECM, surround numerous neurons in […]


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Frugivory and seed predation of fishtail palm (Caryota mitis Lour.) on the remote oceanic island of Narcondam, India

Kavli Affiliate: V. S. Ramachandran | Authors: Abhishek Gopal, Sartaj Ghuman, Navendu Page, Vivek Ramachandran and Rohit Naniwadekar | Summary: Oceanic islands, due to their evolutionary history and isolation, hold a disproportionately high proportion of endemic species. However, their evolutionary history also makes them vulnerable to extinctions, with most known extinctions occurring on islands. Plant-animal […]


Continue.. Frugivory and seed predation of fishtail palm (Caryota mitis Lour.) on the remote oceanic island of Narcondam, India

Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure

Kavli Affiliate: Mark Ellisman | Authors: Tylor R Lewis, Sebastien Phan, Carson M Castillo, Keun-Young Kim, Kelsey Coppenrath, William Thomas, Ying Hao, Nikolai P Skiba, Marko E Horb, Mark H Ellisman and Vadim Y Arshavsky | Summary: The first steps of vision take place within a stack of tightly packed disc-shaped membranes, or “discs”, located […]


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Structured memory representations develop at multiple time scales in hippocampal-cortical networks

Kavli Affiliate: Anastasia Kiyonaga | Authors: Arielle Tambini, Jacob Miller, Luke Ehlert, Anastasia Kiyonaga and Mark D’Esposito | Summary: Influential views of systems memory consolidation posit that the hippocampus rapidly forms representations of specific events, while neocortical networks extract regularities across events, forming the basis of schemas and semantic knowledge. Neocortical extraction of schematic memory […]


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Predictive Sequence Learning in the Hippocampal Formation

Kavli Affiliate: Terrence Sejnowski | Authors: Yusi Chen, Huanqiu Zhang and Terrence J Sejnowski | Summary: We linked the temporal precision of neural encoding to the implementation of cognitive functions through predictive sequence learning. The hippocampus of rodents receives sequences of sensory inputs from the cortex during exploration and then encodes the sequences with millisecond […]


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SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling

Kavli Affiliate: Jose Ricardo Suarez | Authors: Blanca Dies, Ana de Lucas-Rius, Laura Mendoza, Transito Garcia, Raul Fernandez, Jose Manuel Suarez, Fatima Milhano, Fernando Corrales, Natalia Redondo, Federica Pedrucci, Sara Zaldivar, Maria Angeles Jimenez, Maria Montoya and Juan Jose Garrido | Summary: SARS-CoV-2, the cause of the COVID19 pandemic, possesses eleven accessory proteins encoded in […]


Continue.. SARS-CoV-2 accessory proteins involvement in inflammatory and profibrotic processes through IL11 signaling