Kavli Affiliate: Sidney Strickland | Authors: Daniel S. Gareau, Matija Snuderl, Cheddhi Thomas, Nermin Sumru Bayin, Dimitris Placantonakis, Julia Zou, Anna Yaroslavsky, Michael P. Dietz, Steven L. Jacques, Sidney Strickland, James G. Krueger and Hyung Jin Ahn | Summary: Significance Cerebral vascular reactivity is critical parameters of brain homeostasis in health and disease, but the […]

Kavli Affiliate: Michael W. Young | Authors: Michelle Frankot, Peyton M Mueller, Michael E Young and Cole Vonder Haar | Summary: Statistical errors in preclinical science are a barrier to reproducibility and translation. For instance, linear models (e.g., ANOVA, linear regression) may be misapplied to data that violate assumptions. In behavioral neuroscience and psychopharmacology, linear […]

Kavli Affiliate: Nathaniel Heintz | Authors: Christina Pressl, Kert Mätlik, Laura Kus, Paul Darnell, Ji-Dung Luo, Alison R Weiss, William Liguore, Thomas Carroll, David A Davis, Jodi McBride and Nathaniel Heintz | Summary: The properties of the cell types that are most vulnerable in the Huntington’s disease (HD) cortex, the nature of somatic CAG expansion […]

Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, David A Davis, Matthew R Paul, Thomas S Carroll and Nathaniel Heintz | Summary: Tissue-specific somatic expansion of the mutant Huntingtin (mHTT) CAG tract and regional degeneration of the brain are key features of Huntington’s disease (HD). However, the relationships between somatic CAG […]

Kavli Affiliate: Li Zhao | Authors: Xin Hou, Yong He, Pan Fang, Shi-Qiang Mei, Zan Xu, Wei-Chen Wu, Jun-Hua Tian, Shun Zhang, Zhen-Yu Zeng, Qin-Yu Gou, Gen-Yang Xin, Shi-Jia Le, Yin-Yue Xia, Yu-Lan Zhou, Feng-Ming Hui, Yuan-Fei Pan, John-Sebastian Eden, Zhao-Hui Yang, Chong Han, Yue-Long Shu, Deyin Guo, Jun Li, Edward C Holmes, Zhao-Rong Li […]

Kavli Affiliate: Daniel Mucida, Elaine Fuchs | Authors: Sandra Nakandakari-Higa, Maria Cecilia Campos Canesso, Sarah Walker, Aleksey Chudnovskiy, Johanne T Jacobsen, S. Martina Parigi, Karol Fiedorczuk, Elaine Fuchs, Angelina M Bilate, Giulia Pasqual, Daniel Mucida, Yuri Pritykin and Gabriel D Victora | Summary: Cellular interactions are essential for tissue organization and functionality. In particular, immune […]

Kavli Affiliate: Mary E. Hatten | Authors: Liangguang Leo Lin, Mauricio Torres, Brent Pederson, Huilun Helen Wang, Xiaoqiong Wei, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Michalina Hanzel, Eve Ellen Govek, You Lu, Hui Wang, Zhen Zhao, Mary Elizabeth Hatten, Shengyi E Sun and Ling Qi | Summary: Despite recent advances in our understanding of […]

Kavli Affiliate: Daniel Mucida | Authors: Ainsley Lockhart, Aubrey Reed, Tiago Bruno Rezende de Castro, Calvin Herman, Maria Cecilia Campos Canesso and Daniel Mucida | Summary: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and […]

Kavli Affiliate: Li Zhao | Authors: Michelle Baker, Xibin Zhang, Alexandre Maciel-Guerra, Kubra Babaarslan, Yinping Dong, Wei Wang, Yujie Hu, David Renney, Longhai Liu, Hui Li, Zhiqin Tong, Nicole Pearcy, Meimei Zhang, Yingzhi Geng, Li Zhao, Zhihui Hao, Junshi Chen, Zixin Peng, Fengqin Li and Tania Dottorini | Summary: Sharing among different pathogens and commensals […]

Kavli Affiliate: Erich Jarvis | Authors: Anoushka Joglekar, Wen Hu, Bei Zhang, Oleksandr Narykov, Mark Diekhans, Jennifer Balacco, Lishomwa Ndhlovu, Teresa A Milner, Olivier Fedrigo, Erich D Jarvis, Gloria M Sheynkman, Dmitry Korkin, Margaret Elizabeth Ross and Hagen U Tilgner | Summary: RNA isoforms influence cell identity and function. Until recently, technological limitations prevented a […]