Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

Kavli Affiliate: Daniel Mucida, Elaine Fuchs | Authors: Sandra Nakandakari-Higa, Maria Cecilia Campos Canesso, Sarah Walker, Aleksey Chudnovskiy, Johanne T Jacobsen, S. Martina Parigi, Karol Fiedorczuk, Elaine Fuchs, Angelina M Bilate, Giulia Pasqual, Daniel Mucida, Yuri Pritykin and Gabriel D Victora | Summary: Cellular interactions are essential for tissue organization and functionality. In particular, immune […]


Continue.. Universal recording of cell-cell contacts in vivo for interaction-based transcriptomics

SEL1L-HRD1 ER-associated degradation is a new ataxia gene

Kavli Affiliate: Mary E. Hatten | Authors: Liangguang Leo Lin, Mauricio Torres, Brent Pederson, Huilun Helen Wang, Xiaoqiong Wei, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Michalina Hanzel, Eve Ellen Govek, You Lu, Hui Wang, Zhen Zhao, Mary Elizabeth Hatten, Shengyi E Sun and Ling Qi | Summary: Despite recent advances in our understanding of […]


Continue.. SEL1L-HRD1 ER-associated degradation is a new ataxia gene

Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

Kavli Affiliate: Daniel Mucida | Authors: Ainsley Lockhart, Aubrey Reed, Tiago Bruno Rezende de Castro, Calvin Herman, Maria Cecilia Campos Canesso and Daniel Mucida | Summary: The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and […]


Continue.. Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China

Kavli Affiliate: Li Zhao | Authors: Michelle Baker, Xibin Zhang, Alexandre Maciel-Guerra, Kubra Babaarslan, Yinping Dong, Wei Wang, Yujie Hu, David Renney, Longhai Liu, Hui Li, Zhiqin Tong, Nicole Pearcy, Meimei Zhang, Yingzhi Geng, Li Zhao, Zhihui Hao, Junshi Chen, Zixin Peng, Fengqin Li and Tania Dottorini | Summary: Sharing among different pathogens and commensals […]


Continue.. Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China

Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

Kavli Affiliate: Erich Jarvis | Authors: Anoushka Joglekar, Wen Hu, Bei Zhang, Oleksandr Narykov, Mark Diekhans, Jennifer Balacco, Lishomwa Ndhlovu, Teresa A Milner, Olivier Fedrigo, Erich D Jarvis, Gloria M Sheynkman, Dmitry Korkin, Margaret Elizabeth Ross and Hagen U Tilgner | Summary: RNA isoforms influence cell identity and function. Until recently, technological limitations prevented a […]


Continue.. Single-cell long-read mRNA isoform regulation is pervasive across mammalian brain regions, cell types, and development

Studying of RNA-protein interactions between a mutant form of glycyl-tRNA synthetase associated with neurodegenerative diseases and IRES type I

Kavli Affiliate: Ekaterina V. Vinogradova | Authors: Ekaterina Vinogradova, Alisa Mikhaylina, Oleg Nikonov and Ekaterina Nikonova | Summary: Aminoacyl-tRNA synthetases (aaRS) are the main enzymes of protein biosynthesis. Human glycyl-tRNA synthetase, in addition to the main function of amino acid transfer to the corresponding tRNA molecules, is also involved in the initiation of IRES I […]


Continue.. Studying of RNA-protein interactions between a mutant form of glycyl-tRNA synthetase associated with neurodegenerative diseases and IRES type I

Mesoscale volumetric light field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz

Kavli Affiliate: Alipasha Vaziri | Authors: Tobias Nöbauer, Yuanlong Zhang, Hyewon Kim and Alipasha Vaziri | Summary: Various implementations of mesoscopes provide optical access for calcium imaging across multi-millimeter fields-of-view (FOV) in the mammalian brain. However, capturing the activity of the neuronal population within such FOVs near-simultaneously and in a volumetric fashion has remained challenging […]


Continue.. Mesoscale volumetric light field (MesoLF) imaging of neuroactivity across cortical areas at 18 Hz

Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

Kavli Affiliate: Charles M. Rice | Authors: Ariane J Brown, John Won, Raphael Wolfisberg, Ulrik Fanhoe, Nicholas Catanzaro, Ande West, Fernando Moreira, Mariana Nogeuira Batista, Martin T. Ferris, Colton Linnertz, Sarah R Leist, Cameron Nguyen, Gabriella De la Cruz, Bentley Midkiff, Yongjuan Xia, Stephanie A Montgomery, Eva Billerbeck, Jens Bukh, Troels Scheel, Charles M Rice […]


Continue.. Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Kavli Affiliate: Michael W. Young | Authors: Yi Sun, Michael C Young, Claire H Woodward, Julia N Danon, Hau V Truong, Sagar Gupta, Trenton J Winters, George Burslem and Nikolaos G Sgourakis | Summary: The polymorphic nature and intrinsic instability of class I major histocompatibility complex (MHC-I) and MHC-like molecules loaded with suboptimal peptides, metabolites, […]


Continue.. Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Genomic, genetic and phylogenetic evidence for a new falcon species using chromosome-level genome assembly of the gyrfalcon and population genomics

Kavli Affiliate: Erich Jarvis | Authors: Farooq Omar Al-Ajli, Giulio Formenti, Olivier Fedrigo, Alan Tracey, Ying Sims, Kerstin Howe, Ikdam Karkhi, Asmaa Althani, Erich Jarvis, Sadequr Rahman and Qasim Ayub | Summary: The taxonomic classification of a falcon population found in the Altai region in Asia has been heavily debated for two centuries and previous […]


Continue.. Genomic, genetic and phylogenetic evidence for a new falcon species using chromosome-level genome assembly of the gyrfalcon and population genomics