Kavli Affiliate: Eric D. Siggia | Authors: Teresa Krammer, Hannah Taylor Stuart, Elena Gromberg, Keisuke Ishihara, Manuela Melchionda, Jingkui Wang, Elena Costantini, Stefanie Lehr, Dillon Cislo, Laura Arbanas, Alexandra Hoermann, Ralph Alexander Neumueller, Nicola Elvassore, Eric Siggia, James Briscoe, Anna Kicheva and Elly Margaret Tanaka | Summary: Organoids can undergo pattern formation by spontaneously forming […]

Kavli Affiliate: Michael W. Young | Authors: Georgia F Papadaki, Claire H Woodward, Michael C Young, Trenton J Winters, George M Burslem and Nikolaos G Sgourakis | Summary: Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to the endoplasmic […]

Kavli Affiliate: Ali H. Brivanlou | Authors: Tiago L Laundos, Shu Li, Eric Cheang, Riccardo De Santis, Francesco M Piccolo and Ali H. Brivanlou | Summary: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether […]

Kavli Affiliate: Shai Shaham | Authors: Itai Rieger, Guy Weintraub, Itamar Lev, Kesem Goldstein, Dana Bar-Zvi, Sarit Anava, Hila Gingold, Shai Shaham and Oded Rechavi | Summary: Studies using C. elegans nematodes demonstrated that, against the dogma, animals can transmit epigenetic information transgenerationally. While it is now clear that in these worms ancestral RNA interference […]

Kavli Affiliate: Nathaniel Heintz | Authors: Kert Mätlik, Matthew Baffuto, Laura Kus, Amit Laxmikant Deshmukh, David A Davis, Matthew R Paul, Thomas S Carroll, Marie-Christine Caron, Jean-Yves Masson, Christopher E Pearson and Nathaniel Heintz | Summary: Brain region-specific degeneration and somatic expansions of the mutant Huntingtin (mHTT) CAG tract are key features of Huntington’s disease […]

Kavli Affiliate: Charles M. Rice | Authors: Shira Weingarten-Gabbay, Da-Yuan Chen, Siranush Sarkizova, Hannah B Taylor, Matteo Gentili, Leah R Pearlman, Matthew R Bauer, Charles M Rice, Karl R Clauser, Nir Hacohen, Steven A Carr, Jennifer G Abelin, Mohsan Saeed and Pardis C Sabeti | Summary: Targeted synthetic vaccines have the potential to transform our […]

Kavli Affiliate: Li Zhao | Authors: Philipp Kaldis and Li Na Zhao | Summary: piRNAs are important in protecting germline integrity. 3’-terminal 2’-O-methylation is essential for piRNA maturation and to protect it from degradation. HENMT1 carries out the 2’-O-methylation, which is of key importance for piRNA stability and functionality. However, neither the structure nor the […]

Kavli Affiliate: Michael W. Young | Authors: Yi Sun, Tyler J. Florio, Sagar Gupta, Michael C. Young, Quinlen F. Marshall, Samuel E. Garfinkle, Georgia F. Papadaki, Hau V. Truong, Emily Mycek, Peiyao Li, Alvin Farrel, Nicole L. Church, Shereen Jabar, Matthew D. Beasley, Ben R. Kiefel, Mark Yarmarkovich, Leena Mallik, John M. Maris and Nikolaos […]

Kavli Affiliate: Elaine Fuchs | Authors: Katherine S Stewart, Kevin AU Gonzales, Shaopeng Yuan, Matthew T Tierney, Alain R Bonny, Yihao Yang, Nicole R Infarinato, Christopher J Cowley, John M Levorse, H Amalia Pasolli, Sourav Ghosh, Carla V Rothlin and Elaine Fuchs | Summary: Macrophages and dendritic cells have long been appreciated for their ability […]

Kavli Affiliate: Ali H. Brivanlou | Authors: Riccardo De Santis, Eleni Rice, Gist Croft, Min Yang, Edwin A. Rosado-Olivieri and Ali H. Brivanlou | Summary: While studied extensively in model systems, human gastrulation remains obscure. This process starts upon blastocyst implantation into the uterine wall, which is assumed to occur after 14 days post-fertilization. The […]