Kavli Affiliate: Vanessa Ruta | Authors: Rory T Coleman, Ianessa Morantte, Gabriel T Koreman, Megan L Cheng, Yun Ding and Vanessa Ruta | Summary: Identifying a mate is a central imperative for males of most species but poses the challenge of distinguishing a suitable partner from an array of potential male competitors or females of […]
Kavli Affiliate: Alipasha Vaziri, Jeffrey M. Friedman | Authors: Bowen Tan, Caleb J Browne, Tobias Nobauer, Alipasha Vaziri, Jeffrey M. Friedman and Eric J. Nestler | Summary: Addiction prioritizes drug use over innate needs by hijacking brain circuits that direct motivation, but how this develops remains unclear. Using whole-brain FOS mapping and in vivo single-neuron […]
Kavli Affiliate: Cori Bargmann | Authors: Elias Scheer and Cori Bargmann | Summary: Foraging animals optimize feeding decisions by adjusting both common and rare behavioral patterns. Here, we characterize the relationship between an animal’s arousal state and a rare decision to leave a patch of bacterial food. Using long-term tracking and behavioral state classification, we […]
Kavli Affiliate: Roderick MacKinnon | Authors: Maria Elizabeth Falzone and Roderick MacKinnon | Summary: PLCβ enzymes cleave PIP2 producing IP3 and DAG. PIP2 modulates the function of many ion channels, while IP3 and DAG regulate intracellular Ca2+ levels and protein phosphorylation by protein kinase C, respectively. PLCb enzymes are under the control of GPCR signaling […]
Kavli Affiliate: Timothy A. Ryan, Timothy Brown | Authors: Jonathan S Marvin, Alexandros C Kokotos, Mukesh Kumar, Camila Pulido, Ariana N Tkachuk, Jocelyn Shuxin Yao, Timothy A Brown and Timothy A Ryan | Summary: We developed a significantly improved genetically encoded quantitative adenosine triphosphate (ATP) sensor to provide real-time dynamics of ATP levels in subcellular […]
Kavli Affiliate: Michael Higley, Alipasha Vaziri, Kristina Nielsen | Authors: Che-Hang Yu, Yiyi Yu, Liam M. Adsit, Jeremy T. Chang, Jad Barchini, Andrew H. Moberly, Hadas Benisty, Jinkyung Kim, Brent K Young, Kathleen Heng, Deano M. Farinella, Austin Leikvoll, Rishaab Pavan, Rachel Vistein, Brandon R. Nanfito, David G. C. Hildebrand, Santiago Otero-Coronel, Alipasha Vaziri, Jeffery […]
Kavli Affiliate: Winrich Freiwald | Authors: Amirhossein Farzmahdi, Wilbert Zarco, Winrich Freiwald, Nikolaus Kriegeskorte and Tal Golan | Summary: Primates can recognize objects despite 3D geometric variations such as in-depth rotations. The computational mechanisms that give rise to such invariances are yet to be fully understood. A curious case of partial invariance occurs in the […]
Kavli Affiliate: Erich Jarvis | Authors: Delphine Lariviere, Linelle Abueg, Nadolina Brajuka, Cristobal Gallardo-Alba, Bjorn Gruning, Byung June Ko, Alex Ostrovsky, Marc Palmada-Flores, Brandon D. Pickett, Keon Rabbani, Jennifer R. Balacco, Mark Chaisson, Haoyu Cheng, Joanna Collins, Alexandra Denisova, Olivier Fedrigo, Guido Roberto Gallo, Alice Maria Giani, Grenville MacDonald Gooder, Nivesh Jain, Cassidy Johnson, Heebal […]
Kavli Affiliate: Li Zhao | Authors: Samuel Khodursky, Eric B Zheng, Nicolas Svetec, Sylvia M Durkin, Sigi Benjamin, Alice Gadau, Xia Wu and Li Zhao | Summary: The evolution of regulatory regions in the genome plays a critical role in shaping the diversity of life. While this process is primarily sequence-dependent, the enormous complexity of […]
Kavli Affiliate: Li Zhao | Authors: Junhui Peng and Li Zhao | Summary: Although previously thought to be unlikely, recent studies have shown that de novo gene origination from previously non-genic sequences is a common mechanism for gene innovation in many species and taxa. These young genes provide a unique set of candidates to study […]