Synaptic architecture of a memory engram in the mouse hippocampus

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Marco Uytiepo, Mark Ellisman and Anton Maximov | Summary: Memory engrams are formed through experience-dependent remodeling of neural circuits, but their detailed architectures have remained unresolved. Using 3D electron microscopy, we performed nanoscale reconstructions of the hippocampal CA3-CA1 pathway following chemogenetic labeling of cellular ensembles with a remote history […]


Continue.. Synaptic architecture of a memory engram in the mouse hippocampus

The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States

Posted by dbos UCSD / Salk

Kavli Affiliate: Eiman Azim | Authors: Aman Upadhyay, Mark A Gradwell, Thomas J Vajtay, James Conner, Arnab A Sanyal, Chloe Azadegan, Komal R Patel, Joshua K Thackray, Manon Bohic, Fumiyasu Imai, Simon O Ogundare, Yutaka Yoshida, Ishmail Abdus-Saboor, Eiman Azim and Victoria Eugenia Guadalupe Abraira | Summary: Tactile perception relies on reliable transmission and modulation […]


Continue.. The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States

Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

Posted by dbos UCSD / Salk, UCSF

Kavli Affiliate: Seth Shipman Eiman Azim | Authors: Abdulkadir Ozkan, Hari K Padmanabhan, Seth Shipman, Eiman Azim, Priyanka Kumar, Cameron Sadegh, Nazli Basak and Jeffrey D Macklis | Summary: Corticospinal neurons (CSN) centrally degenerate in amyotrophic lateral sclerosis (ALS), along with spinal motor neurons, and loss of voluntary motor function in spinal cord injury (SCI) […]


Continue.. Directed differentiation of functional corticospinal-like neurons from endogenous SOX6+/NG2+ cortical progenitors

The representational geometry of emotional states in basolateral amygdala

Posted by klaurent Columbia

Kavli Affiliate: Stefano Fusi, Daniel Salzman | Authors: Pia-Kelsey O’Neill, Lorenzo Posani, Jozsef Meszaros, Phebe Warren, Carl E. Schoonover, Andrew J.P. Fink, Stefano Fusi and C. Daniel Salzman | Summary: Sensory stimuli associated with aversive outcomes can cause multiple behavioral responses related to an animal’s evolving emotional state. We employed chemogenetic inactivation and two-photon imaging […]


Continue.. The representational geometry of emotional states in basolateral amygdala

Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

Posted by dbos Columbia

Kavli Affiliate: Seth Blackshaw | Authors: Dong Won Kim, Soohyun Kim, Jeong Han, Karan Belday, Emily Li, Nicholas Mahoney, Seth Blackshaw and Fatemeh Rajaii | Summary: Despite recent advances in the treatment of thyroid eye disease (TED), significant gaps remain in our understanding of the underlying molecular mechanisms, particularly concerning the insulin-like growth factor-1 receptor […]


Continue.. Transcriptomic Profiling of Thyroid Eye Disease Orbital Fat Demonstrates Differences in Adipogenicity and IGF-1R Pathway

Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

Posted by dbos Rockefeller

Kavli Affiliate: Michael W. Young | Authors: Michael Young, David M Booth, David Smith, Marco Tigano, Gyorgy Hajnoczky and Suresh Joseph | Summary: The activation of IP3 receptor (IP3R) Ca2+ channels generates agonist-mediated Ca2+ signals that regulate a wide range of biological processes. It is therefore surprising that CRISPR induced loss of all three IP3R […]


Continue.. Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling

A Subcortical Feeding Circuit Linking Interoception to Jaw movement

Posted by dbos Rockefeller, UCSF

Kavli Affiliate: Jeffrey M. Friedman and Zachary Knight | Authors: Christin Kosse, Jessica Ivanov, Zachary Knight, Kyle Pellegrino and Jeffrey Friedman | Summary: The brain processes an array of stimuli enabling the selection of an appropriate behavioural response but the neural pathways linking interoceptive inputs to outputs for feeding are poorly understood. Here we delineate […]


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Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Posted by klaurent Hopkins

Kavli Affiliate: Denis Wirtz | Authors: Devon E Mason, Megan Goeckel, Sebastian L Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A Burdick, Levi Wood, Brain Y Chow, Amber N Stratman and Joel D Boerckel | Summary: Vascular morphogenesis requires persistent endothelial cell motility that is responsive to diverse and dynamic mechanical stimuli. […]


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Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

Posted by dbos Rockefeller

Kavli Affiliate: A. James Hudspeth | Authors: Agnik Dasgupta, Caleb C. Reagor, Sang Peter Paik, Lauren M Snow, Adrian Jacobo and Albert Hudspeth | Summary: In a developing nervous system, axonal arbors often undergo complex rearrangements before neural circuits attain their final innervation topology. In the lateral line sensory system of the zebrafish, developing sensory […]


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A low-resource reliable pipeline to democratize multi-modal connectome estimation and analysis

Posted by dbos Hopkins

Kavli Affiliate: Brian Caffo Randal Burns Carey Priebe Joshua Vogelstein | Authors: Jaewon Chung, Ross Lawrence, Alexander Loftus, Gregory Kiar, Eric Bridgeford, Consortium for Reliability and Reproducibility, Vikram Chandrashekhar, Disa Mhembere, Sephira Ryman, Xi-Nian Zuo, Daniel Margulies, R. Cameron Craddock, Carey E. Priebe, Rex Jung, Vince D. Calhoun, Brian Caffo, Randal Burns, Michael P. Milham […]


Continue.. A low-resource reliable pipeline to democratize multi-modal connectome estimation and analysis