EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms

Posted by klaurent UCSF

Kavli Affiliate: Daniel Minor | Authors: Zhou Chen, Abhisek Mondal, Fayal Abderemane-Ali, Jose Montano, Balyn Zaro and Daniel L Minor, Jr. | Summary: Abstract Voltage-gated ion channels (VGICs) comprise multiple structural units whose assembly is required for function1,2. There is scant structural understanding of how VGIC subunits assemble and whether chaperone proteins are required. High-voltage […]


Continue.. EMC holdase:CaV1.2/CaVβ3 complex and CaV1.2 channel structures reveal CaV assembly and drug binding mechanisms

Three-dimensional genome re-wiring in loci with Human Accelerated Regions

Posted by klaurent UCSF

Kavli Affiliate: Alex Pollen | Authors: Kathleen C Keough, Sean Whalen, Fumitaka Inoue, Pawel F Przytycki, Tyler Fair, Chengyu Deng, Marilyn Steyert, Hane Ryu, Kerstin Lindblad-Toh, Elinor Karlsson, Zoonomia Consortium, Tomasz J. Nowakowski, Nadav J. Ahituv, Alex Aaron Pollen and Katherine S Pollard | Summary: Abstract Human Accelerated Regions (HARs) are conserved genomic loci that […]


Continue.. Three-dimensional genome re-wiring in loci with Human Accelerated Regions

Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys

Posted by klaurent Hopkins

Kavli Affiliate: Jeremiah Cohen | Authors: Jae Hyung Woo, Claudia G Aguirre, Bilal A Bari, Ken-Ichiro Tsutsui, Fabian Grabenhorst, Jeremiah Y Cohen, Wolfram Schultz, Alicia Izquierdo and Alireza Soltani | Summary: Abstract Despite being unpredictable and uncertain, reward environments often exhibit certain regularities, and animals navigating these environments try to detect and utilize such regularities […]


Continue.. Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys

Resting-State Electroencephalography for Continuous, Passive Prediction of Coma Recovery After Acute Brain Injury

Posted by klaurent Rockefeller

Kavli Affiliate: Michael Young | Authors: Morteza Zabihi, Daniel B. Rubin, Sophie E. Ack, Emily J. Gilmore, Valdery Moura Junior, Sahar F. Zafar, Quanzheng Li, Michael J. Young, Brian L. Edlow, Yelena G. Bodien and Eric S. Rosenthal | Summary: Abstract Accurately predicting emergence from disorders of consciousness (DoC) after acute brain injury can profoundly […]


Continue.. Resting-State Electroencephalography for Continuous, Passive Prediction of Coma Recovery After Acute Brain Injury

Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments

Posted by klaurent UCSF

Kavli Affiliate: Stanley Prusiner | Authors: Gregory E. Merz, Matthew J. Chalkley, Sophia Tan, Eric Tse, Joanne Lee, Stanley B. Prusiner, Nick A. Paras, William F. DeGrado and Daniel R. Southworth | Summary: Abstract Neurodegenerative diseases (NDs) are characterized by the formation of amyloid filaments that adopt disease-specific conformations in the brain. Recently developed small […]


Continue.. Stacked binding of a small molecule PET tracer to Alzheimer’s tau paired helical filaments

Transient, developmental exposure to patient-derived anti-NMDA receptor autoantibodies causes long-term axonal and behavioral defects

Posted by klaurent UCSF

Kavli Affiliate: Samuel Pleasure | Authors: Jing Zhou, Ariele Greenfield, Rita Loudermilk, Christopher Bartley, Baouyen Tran, Chao Zhao, Hong Wang, Michael Wilson and Samuel Pleasure | Summary: Abstract NMDA receptor autoimmune encephalitis (NMDAR-AE) is characterized by cerebrospinal fluid (CSF)-resident anti-NMDA receptor autoantibodies that cause behavioral and neurologic deficits. Although many symptoms are responsive to immunotherapy, […]


Continue.. Transient, developmental exposure to patient-derived anti-NMDA receptor autoantibodies causes long-term axonal and behavioral defects

Microbiota-dependent histone butyrylation in the mammalian intestine

Posted by klaurent Rockefeller

Kavli Affiliate: Daniel S. Mucida | Authors: Leah A Gates, Bernardo Sgarbi Reis, Peder J Lund, Matthew R Paul, Marylene Leboeuf, Zara Nadeem, Thomas S Carroll, Benjamin Garcia, Daniel Mucida and C. David Allis | Summary: SUMMARY Posttranslational modifications (PTMs) on histone proteins are a key source of regulation on chromatin through impacting genome organization […]


Continue.. Microbiota-dependent histone butyrylation in the mammalian intestine

MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Posted by klaurent Hopkins

Kavli Affiliate: Dwight Bergles | Authors: Em P Harrington, Riley B Catenacci, Matthew D Smith, Dongeun Heo, Cecilia E Miller, Keya R Meyers, Jenna Glatzer, Dwight E Bergles and Peter A Calabresi | Summary: Abstract Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown […]


Continue.. MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Feasibility Analyses and Experimental Confirmation of Dove Prism Based Dual-fiberscope Rotary Joint

Posted by klaurent Hopkins

Kavli Affiliate: Xingde Li | Authors: Yuehan Liu, Hyeon-Cheol Park, Haolin Zhang and Xingde Li | Summary: Abstract Two-photon fluorescence microscopy has enjoyed its wide adoption in neuroscience. Head-mounted miniaturized fiberscopes offered an exciting opportunity for enabling neural imaging in freely-behaving animals with high 3D resolution. Here we propose a dual-fiberscope rotary joint based on […]


Continue.. Feasibility Analyses and Experimental Confirmation of Dove Prism Based Dual-fiberscope Rotary Joint

Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Posted by klaurent UCSD / Salk

Kavli Affiliate: Samuel Pfaff | Authors: Lydia Daboussi, Giancarlo Costaguta, Miriam Gullo, Veronica Pessino, Brendan O’Leary, Karen Lettieri, Shawn Driscoll and Samuel L. Pfaff | Summary: Abstract Schwann cells respond to acute axon damage by transiently transdifferentiating into specialized repair cells that restore sensorimotor function. However, the molecular systems controlling repair cell formation and function […]


Continue.. Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair