Internal noise promotes heterogeneous synaptic dynamics important for working memory in recurrent neural networks

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Nuttida Rungratsameetaweemana, Robert Kim and Terrence Sejnowski | Summary: Abstract Recurrent neural networks (RNNs) based on model neurons that communicate via continuous signals have been widely used to study how cortical neurons perform cognitive tasks. Training such networks to perform tasks that require information maintenance over a brief period […]


Continue.. Internal noise promotes heterogeneous synaptic dynamics important for working memory in recurrent neural networks

DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-Analysis

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Antonio Pinto-Duarte, Katherine Bogue, Terrence J Sejnowski and Shyam Srinivasan | Summary: Abstract Epigenetic changes are involved in the onset and progression of cancer, and the detection of DNA methylation signatures may foster the improvement of diagnosis and prognosis. While the emergence of innovative technologies has fostered numerous studies […]


Continue.. DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-Analysis

Molecular programs of regional specification and neural stem cell fate progression in developing macaque telencephalon

Posted by klaurent Yale

Kavli Affiliate: Pasko Rakic, Nenad Sestan | Authors: Nicola Micali, Shaojie Ma, Mingfeng Li, Suel-Kee Kim, Xoel Mato-Blanco, Suvimal Sindhu, Jon I. Arellano, Tianliuyun Gao, Alvaro Duque, Gabriel Santpere, Nenad Sestan and Pasko Rakic | Summary: Abstract Early telencephalic development involves patterning of the distinct regions and fate specification of the neural stem cells (NSCs). […]


Continue.. Molecular programs of regional specification and neural stem cell fate progression in developing macaque telencephalon

Knowledge Mapping of Alternative Splicing of Cancer From 2012 to 2021: A Bibliometric Analysis

Posted by klaurent Rockefeller

Kavli Affiliate: Li Zhao | Authors: Bo Tian, Yan Bian, De-Jian Bian, Ye Gao, Xun Zhang, Si-Wei Zhou, Yan-Hui Zhang, Ya-Nan Pang, Zhao-Shen Li and Luo-Wei Wang | Summary: ABSTRACT Background As a processing method of RNA precursors, alternative splicing plays a critical role in normal cell physiological activities. Aberrant alternative splicing events are associated […]


Continue.. Knowledge Mapping of Alternative Splicing of Cancer From 2012 to 2021: A Bibliometric Analysis

A machine learning based approach towards high-dimensional mediation analysis

Posted by klaurent Hopkins

Kavli Affiliate: Brian Caffo, Martin Lindquist | Authors: Tanmay Nath, Brian Caffo, Tor Wager and Martin Lindquist | Summary: Abstract Mediation analysis is used to investigate the role of intermediate variables (mediators) that lie in the path between an exposure and an outcome variable. While significant research has focused on developing methods for assessing the […]


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Pantr2, a trans-acting lncRNA, modulates the differentiation potential of neural progenitors in vivo

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw, Loyal Goff | Authors: Jonathan J Augustin, Saki Takayangi, Thanh Hoang, Briana Winer, Seth Blackshaw and Loyal A Goff | Summary: Abstract Ablation of the long non-coding RNA (lncRNA) Pantr2 re- sults in microcephaly in a knockout murine model of cor- ticogenesis, however, the precise mechanisms used are un- known. We […]


Continue.. Pantr2, a trans-acting lncRNA, modulates the differentiation potential of neural progenitors in vivo

Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus

Posted by klaurent UCSD / Salk

Kavli Affiliate: Eran Mukamel | Authors: Matthew G Heffel, Jingtian Zhou, Yi Zhang, Dong-Sung Lee, Kangcheng Hou, Oier Pastor Alonso, Kevin Abuhanna, Anthony D Schmitt, Terence Li, Maximilian Haeussler, Brittney Wick, Martin Jinye Zhang, Fangming Xie, Ryan S Ziffra, Eran A Mukamel, Eleazar Eskin, Bogdan Pasaniuc, Joseph R. Ecker, Jesse Dixon, Tomasz J. Nowakowski, Mercedes […]


Continue.. Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus

Biogeography of human-health associated butyrate-producing bacteria

Posted by klaurent UCSF

Kavli Affiliate: Robert Edwards | Authors: Joel E Brame, Craig Liddicoat, Catherine A Abbott, Robert A Edwards, Jake M Robinson, Nicolas E Gauthier and Martin F Breed | Summary: Abstract Butyrate-producing bacteria are found in many ecosystems and organisms, including humans. They ferment organic matter, producing the by-product butyrate, a short-chain fatty acid with important […]


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Dopamine signaling regulates predator-driven behavioral changes in Caenorhabditis elegans

Posted by klaurent UCSD / Salk

Kavli Affiliate: Sreekanth Chalasani | Authors: Amy Pribadi, Kaila Rosales, Kirthi C Reddy and Sreekanth H Chalasani | Summary: Abstract Prey respond to predators by altering their behavior to optimize their own fitness and survival. We probe the interactions between Caenorhabditis elegans and its naturally cohabiting predator Pristionchus uniformis to reveal the pathways driving changes […]


Continue.. Dopamine signaling regulates predator-driven behavioral changes in Caenorhabditis elegans

Oscillations and aperiodic activity: Evidence for dynamic changes in both during memory encoding

Posted by klaurent UCSD / Salk

Kavli Affiliate: Bradley Voytek | Authors: Michael Preston, Natalie Schaworonkow and Bradley Voytek | Summary: Abstract Electrical recordings of human brain activity via electroencephalography (EEG) show prominent, rhythmic voltage fluctuations. These periodic oscillations have been linked to nearly every cognitive and perceptual process, as well numerous disease states. Recent methodological and theoretical advances, however, have […]


Continue.. Oscillations and aperiodic activity: Evidence for dynamic changes in both during memory encoding