Potassium regulates axon-oligodendrocyte signaling and metabolic coupling in white matter

Kavli Affiliate: Dwight Bergles | Authors: Zoe J. Looser, Luca Ravotto, Ramona B. Jung, Hauke B. Werner, Torben Ruhwedel, Wiebke Moebius, Dwight E Bergles, L. Felipe Barros, Klaus-Armin Nave, Bruno Weber and Aiman S. Saab | Summary: Abstract The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs), which is essential for brain […]


Continue.. Potassium regulates axon-oligodendrocyte signaling and metabolic coupling in white matter

Comparative analysis of single-cell and single-nucleus RNA-sequencing in a rabbit model of retinal detachment-related proliferative vitreoretinopathy.

Kavli Affiliate: Seth Blackshaw | Authors: Clayton P. Santiago, Megan Y. Gimmen, Yuchen Lu, Minda M. McNally, Leighton H. Duncan, Tyler Creamer, Linda Orzolek, Seth Blackshaw and Mandeep Singh | Summary: Structured Abstract Purpose Proliferative vitreoretinopathy (PVR) is the most common cause of failure of retinal reattachment surgery and the molecular changes leading to this […]


Continue.. Comparative analysis of single-cell and single-nucleus RNA-sequencing in a rabbit model of retinal detachment-related proliferative vitreoretinopathy.

Structured Joint Decomposition (SJD) identifies conserved molecular dynamics across collections of biologically related multi-omics data matrices

Kavli Affiliate: Brian Caffo | Authors: Huan Chen, Jinrui Liu, Shreyash Sonthalia, Genevieve Stein-OBrien, Luo Xiao, Brian Caffo and Carlo Colantuoni | Summary: Abstract Motivation It is necessary to develop exploratory tools to learn from the unprecedented volume of high-dimensional multi-omic data currently being produced. We have developed an R package, SJD, which identifies components […]


Continue.. Structured Joint Decomposition (SJD) identifies conserved molecular dynamics across collections of biologically related multi-omics data matrices

Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

Kavli Affiliate: Dwight Bergles, Patrick Kanold | Authors: Calvin J Kersbergen, Travis A Babola, Patrick O Kanold and Dwight E Bergles | Summary: ABSTRACT Intrinsically generated neural activity propagates through the developing auditory system to promote maturation and refinement of sound processing circuits prior to hearing onset. This early patterned activity is induced by non-sensory […]


Continue.. Preservation of prehearing spontaneous activity enables early auditory system development in deaf mice

The BRAIN Initiative Cell Census Data Ecosystem: A User’s Guide

Kavli Affiliate: Michael Miller | Authors: BICCN Data Ecosytem Collaboration, Michael J Hawrylycz, Maryann E Martone, Patrick R Hof, Ed S Lein, Aviv Regev, Giorgio A. A Ascoli, Jan G Bjaalie, Hong-Wei Dong, Satrajit S Ghosh, Jesse Gillis, Ronna Hertzano, David R Haynor, Yongsoo Kim, Yufeng Liu, Jeremy A Miller, Partha P Mitra, Eran Mukamel, […]


Continue.. The BRAIN Initiative Cell Census Data Ecosystem: A User’s Guide

Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

Kavli Affiliate: Alex Kolodkin | Authors: Eleftheria Koropouli, Qiang Wang, Rebeca Mejias-Estevez, Randal Hand, Tao Wang, David D Ginty and Alex L Kolodkin | Summary: ABSTRACT Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the elaboration […]


Continue.. Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

MLL1 regulates cytokine-driven cell migration and metastasis

Kavli Affiliate: Denis Wirtz | Authors: Praful R Nair, Ludmila Danilova, Estibaliz Gómez-de-Mariscal, Dongjoo Kim, Rong Fan, Arrate Munoz-Barrutia, Elana J Fertig and Denis Wirtz | Summary: Abstract Cell migration is a critical requirement for cancer metastasis. Cytokine production and its role in cancer cell migration have been traditionally associated with immune cells in the […]


Continue.. MLL1 regulates cytokine-driven cell migration and metastasis

A machine learning based approach towards high-dimensional mediation analysis

Kavli Affiliate: Brian Caffo, Martin Lindquist | Authors: Tanmay Nath, Brian Caffo, Tor Wager and Martin Lindquist | Summary: Abstract Mediation analysis is used to investigate the role of intermediate variables (mediators) that lie in the path between an exposure and an outcome variable. While significant research has focused on developing methods for assessing the […]


Continue.. A machine learning based approach towards high-dimensional mediation analysis

Pantr2, a trans-acting lncRNA, modulates the differentiation potential of neural progenitors in vivo

Kavli Affiliate: Seth Blackshaw, Loyal Goff | Authors: Jonathan J Augustin, Saki Takayangi, Thanh Hoang, Briana Winer, Seth Blackshaw and Loyal A Goff | Summary: Abstract Ablation of the long non-coding RNA (lncRNA) Pantr2 re- sults in microcephaly in a knockout murine model of cor- ticogenesis, however, the precise mechanisms used are un- known. We […]


Continue.. Pantr2, a trans-acting lncRNA, modulates the differentiation potential of neural progenitors in vivo

Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys

Kavli Affiliate: Jeremiah Cohen | Authors: Jae Hyung Woo, Claudia G Aguirre, Bilal A Bari, Ken-Ichiro Tsutsui, Fabian Grabenhorst, Jeremiah Y Cohen, Wolfram Schultz, Alicia Izquierdo and Alireza Soltani | Summary: Abstract Despite being unpredictable and uncertain, reward environments often exhibit certain regularities, and animals navigating these environments try to detect and utilize such regularities […]


Continue.. Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys