The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Kavli Affiliate: Michela Gallagher | Authors: Dong-Hee Kim, In-Beom Jin, Nam-Heon Kim, Yong-Jae Jeon, Bo-Ryoung Choi, Michela Gallagher and Jung-Soo Han | Summary: The lateral habenula (LHb) has been implicated in conditioned inhibition. Here, the modulating effects of LHb activity on the association of a conditioned stimulus (CS) with the nonoccurrence of an unconditioned stimulus […]


Continue.. The lateral habenula mediates the association of a conditioned stimulus with the absence of an appetitive unconditioned stimulus

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Kavli Affiliate: David Linden | Authors: J. Kopal, K. Kumar, K. Saltoun, C. Modenato, C. A. Moreau, S. Martin-Brevet, G. Huguet, M. Jean-Louis, C.O. Martin, Z. Saci, N. Younis, P. Tamer, E. Douard, A. M. Maillard, B. Rodriguez-Herreros, A. Pain, S. Richetin, 16p11.2 European Consortium, Simons Searchlight Consortium, L. Kushan, A. I. Silva, M. B. […]


Continue.. Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

Kavli Affiliate: Michael Miller, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Daniel Tward and Michael Miller | Summary: Reconstructing dense 3D anatomical coordinates from 2D projective measurements has become a central problem in both mouse and human digital pathology. We describe a new family of diffeomorphic mapping technologies called Projective LDDMM which generate diffeomorphic […]


Continue.. Projective LDDMM: Mapping Molecular Digital Pathology with Tissue MRI

Ret loss-of-function decreases enteric neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

Kavli Affiliate: Loyal Goff | Authors: Elizabeth Vincent, Sumantra Chatterjee, Gabrielle H Cannon, Dallas Auer, Holly Ross, Aravinda Chakravarti and Loyal A Goff | Summary: The receptor tyrosine kinase gene RET plays a critical role in the fate specification of enteric neural crest-derived cells (ENCDCs) during enteric nervous system (ENS) development. Pathogenic RET loss of […]


Continue.. Ret loss-of-function decreases enteric neural crest progenitor proliferation and restricts developmental fate potential during enteric nervous system development

Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Kavli Affiliate: Paul Greengard | Authors: Ana Milosevic, Lucian Medrihan, Margarete Knudsens, Tatiana Ferraro, Pedro Del Cioppo Vasques, Yevgeniy Romin, Sho Fujisawa and Paul Greengard | Summary: The cholinergic interneurons (ChATs) of the nucleus accumbens (NAc) have a critical role in the activity of this region, specifically in the context of major depressive disorder. To […]


Continue.. Glutamatergic projections from ventral hippocampus to nucleus accumbens cholinergic neurons are altered in a mouse model of depression

Shell Microelectrode Arrays (MEAs) for brain organoids

Kavli Affiliate: Brian Caffo | Authors: Qi Huang, Bohao Tang, July Carolina Romero, Yuqian Yang, Saifeldeen Khalil Elsayed, Gayatri Pahapale, Tien-Jung Lee, Itzy Erin Morales Pantoja, Fang Han, Cynthia Berlinicke, Terry Xiang, Mallory Solazzo, Thomas Hartung, Zhao Qin, Brian Caffo, Lena Smirnova and David H Gracias | Summary: Brain organoids are important models for mimicking […]


Continue.. Shell Microelectrode Arrays (MEAs) for brain organoids

Spatial and temporal autocorrelation weave complexity in brain networks

Kavli Affiliate: Daeyeol Lee | Authors: Maxwell Shinn, Amber Hu, Laurel Turner, Stephanie Noble, Katrin H Preller, Jie Lisa Ji, Flora Moujaes, Sophie Achard, Dustin Scheinost, R Todd Constable, John Krystal, Franz X Vollenweider, Daeyeol Lee, Alan Anticevic, Edward T Bullmore and John D Murray | Summary: High-throughput experimental methods in neuroscience have led to […]


Continue.. Spatial and temporal autocorrelation weave complexity in brain networks

Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.

Kavli Affiliate: Seth Blackshaw | Authors: Nguyet Le, Haley Appel, Nicole Pannullo, Thanh Hoang and Seth Blackshaw | Summary: Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to-neuron reprogramming […]


Continue.. Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina.

Mesoscopic oblique plane microscopy (Meso-OPM) – enabling large-scale 4D isotropic cellular resolution imaging with a diffractive light sheet

Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make trade-offs […]


Continue.. Mesoscopic oblique plane microscopy (Meso-OPM) – enabling large-scale 4D isotropic cellular resolution imaging with a diffractive light sheet

Mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet- enabling large-scale 4D cellular resolution imaging

Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Abstract Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make […]


Continue.. Mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet- enabling large-scale 4D cellular resolution imaging