Kavli Affiliate: Daeyeol Lee | Authors: Maxwell Shinn, Amber Hu, Laurel Turner, Stephanie Noble, Katrin H Preller, Jie Lisa Ji, Flora Moujaes, Sophie Achard, Dustin Scheinost, R Todd Constable, John Krystal, Franz X Vollenweider, Daeyeol Lee, Alan Anticevic, Edward T Bullmore and John D Murray | Summary: High-throughput experimental methods in neuroscience have led to […]
Kavli Affiliate: Seth Blackshaw | Authors: Nguyet Le, Haley Appel, Nicole Pannullo, Thanh Hoang and Seth Blackshaw | Summary: Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to-neuron reprogramming […]
Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make trade-offs […]
Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Abstract Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make […]
Kavli Affiliate: Susumu Mori | Authors: Steve C.N. Hui, Muhammad Saleh, Helge J Zoellner, Georg Oeltzschner, Hongli Fan, Yue Li, Yulu Song, Hangyi Jiang, Jamie Near, Hanzhang Lu, Susumu Mori and Richard Edden | Summary: Background Accurate quantification of in vivo proton magnetic resonance spectra involves modeling with a linear combination of known metabolite basis […]
Kavli Affiliate: Charles Connor | Authors: Natalie K Trzcinski, Steven S Hsiao, Charles E Connor and Manuel Gomez-Ramirez | Summary: The leading view in the somatosensory system indicates that area 3b serves as a cortical relay site that encodes cutaneous (tactile) features limited to individual digits. Our recent work argues against this model by showing […]
Kavli Affiliate: Jin Kang | Authors: Anca Mihalas, Sonali Arora, Samantha O’Connor, Heather Feldman, John Bassett, Kelly Mitchell, Kang Jin, Pia Hoellerbauer, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Bruce J Aronow, Christopher J Plaisier, Anoop Patel and PATRICK PADDISON | Summary: In solid tumors, G0-like cell populations likely play important roles […]
Kavli Affiliate: Michael Miller, Susumu Mori, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Claire Chen, Eileen Xu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael Miller | Summary: Since Braak’s initial histological observations, it has been recognized that Alzheimer’s disease (AD) neurofibrillary tangles (NFTs) appear in the medial temporal lobe (MTL) […]
Kavli Affiliate: Patrick Kanold | Authors: Beatriz C Borges, Xiangying Meng, Patrick Long, Patrick O Kanold and Gabriel Corfas | Summary: For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on excitatory cells. Recent evidence showed that axons of inhibitory neurons in the neocortex are […]
Kavli Affiliate: Seth Blackshaw | Authors: Cjunyao jiang, Pin Lyu, Jinlian Li, Sunan Huang, Seth Blackshaw, Jiang Qian and Jie Wang | Summary: Although single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase accessible chromatin using sequencing (scATAC-seq) have been widely used, few methods can reliably integrate these data to perform regulatory network analysis. Here, […]