Mesoscopic oblique plane microscopy (Meso-OPM) – enabling large-scale 4D isotropic cellular resolution imaging with a diffractive light sheet

Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make trade-offs […]


Continue.. Mesoscopic oblique plane microscopy (Meso-OPM) – enabling large-scale 4D isotropic cellular resolution imaging with a diffractive light sheet

Mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet- enabling large-scale 4D cellular resolution imaging

Kavli Affiliate: Patrick Kanold | Authors: Wenjun Shao, Minzi Chang, Kevin Emmerich, Patrick O Kanold, Jeff S Mumm and Ji Yi | Summary: Abstract Fundamental understanding of large-scale dynamic connectivity within a living organism requires volumetric imaging over a large field of view (FOV) at biologically relevant speed and resolution. However, most microscopy methods make […]


Continue.. Mesoscopic oblique plane microscopy (Meso-OPM) with a diffractive light sheet- enabling large-scale 4D cellular resolution imaging

MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation

Kavli Affiliate: Susumu Mori | Authors: Steve C.N. Hui, Muhammad Saleh, Helge J Zoellner, Georg Oeltzschner, Hongli Fan, Yue Li, Yulu Song, Hangyi Jiang, Jamie Near, Hanzhang Lu, Susumu Mori and Richard Edden | Summary: Background Accurate quantification of in vivo proton magnetic resonance spectra involves modeling with a linear combination of known metabolite basis […]


Continue.. MRSCloud: a Cloud-based MR Spectroscopy Tool for Basis Set Simulation

Multi-finger Receptive Field Properties in Primary Somatosensory Cortex: A Revised Account of the Spatio-Temporal Integration Functions of Area 3b

Kavli Affiliate: Charles Connor | Authors: Natalie K Trzcinski, Steven S Hsiao, Charles E Connor and Manuel Gomez-Ramirez | Summary: The leading view in the somatosensory system indicates that area 3b serves as a cortical relay site that encodes cutaneous (tactile) features limited to individual digits. Our recent work argues against this model by showing […]


Continue.. Multi-finger Receptive Field Properties in Primary Somatosensory Cortex: A Revised Account of the Spatio-Temporal Integration Functions of Area 3b

KAT5 activity regulates G0-like states in human gliomas

Kavli Affiliate: Jin Kang | Authors: Anca Mihalas, Sonali Arora, Samantha O’Connor, Heather Feldman, John Bassett, Kelly Mitchell, Kang Jin, Pia Hoellerbauer, Melissa Ling, Wesley Jenkins, Megan Kufeld, Philip Corrin, Lucas Carter, Bruce J Aronow, Christopher J Plaisier, Anoop Patel and PATRICK PADDISON | Summary: In solid tumors, G0-like cell populations likely play important roles […]


Continue.. KAT5 activity regulates G0-like states in human gliomas

Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer’s Disease

Kavli Affiliate: Michael Miller, Susumu Mori, Menno Witter | Authors: Kaitlin Stouffer, Menno Witter, Claire Chen, Eileen Xu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael Miller | Summary: Since Braak’s initial histological observations, it has been recognized that Alzheimer’s disease (AD) neurofibrillary tangles (NFTs) appear in the medial temporal lobe (MTL) […]


Continue.. Projective LDDMM: Spatially Reconstructing a Story of Rostrally-Dominant Tau in Alzheimer’s Disease

Hypomyelination reduces parvalbumin interneuron density and auditory cortex inhibitory function

Kavli Affiliate: Patrick Kanold | Authors: Beatriz C Borges, Xiangying Meng, Patrick Long, Patrick O Kanold and Gabriel Corfas | Summary: For a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on excitatory cells. Recent evidence showed that axons of inhibitory neurons in the neocortex are […]


Continue.. Hypomyelination reduces parvalbumin interneuron density and auditory cortex inhibitory function

IReNA: integrated regulatory network analysis of single-cell transcriptomes

Kavli Affiliate: Seth Blackshaw | Authors: Cjunyao jiang, Pin Lyu, Jinlian Li, Sunan Huang, Seth Blackshaw, Jiang Qian and Jie Wang | Summary: Although single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase accessible chromatin using sequencing (scATAC-seq) have been widely used, few methods can reliably integrate these data to perform regulatory network analysis. Here, […]


Continue.. IReNA: integrated regulatory network analysis of single-cell transcriptomes

Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Kavli Affiliate: Dwight Bergles, Seth Blackshaw, Richard Huganir, Patrick Kanold, Kristina Nielsen | Authors: Jonathan Ling, Alexei Bygrave, Clayton Santiago, Rogger Carmen, Vickie Trinh, Minzhong Yu, Yini Li, Jeong Han, Kamil Taneja, Ying Liu, Rochinelle Dongmo, Travis Babola, Patrick Parker, Lizhi Jiang, Patrick Leavey, Jennifer Smith, Rachel Vistein, Megan Gimmen, Benjamin Dubner, Patric Teodorescu, THEODOROS […]


Continue.. Cell-specific regulation of gene expression using splicing-dependent frameshifting.

Loss of functional heterogeneity along the CA3 transverse axis in aging

Kavli Affiliate: Michela Gallagher, James Knierim | Authors: Heekyung Lee, Zitong Wang, Arjuna Tilekeratne, Nick Lukish, Scott Zeger, Michela Gallagher and James J Knierim | Summary: Age-related deficits in pattern separation have been postulated to bias the output of hippocampal memory processing toward pattern completion, which can cause deficits in accurate memory retrieval. While the […]


Continue.. Loss of functional heterogeneity along the CA3 transverse axis in aging