Kavli Affiliate: Patrick Kanold | Authors: Dan Luo, Ji Liu, Ryszard Auksztulewicz, Tony Ka Wing Yip, Patrick O. Kanold and Jan W. Schnupp | Summary: Detecting patterns, and noticing unexpected pattern changes, in the environment is a vital aspect of sensory processing. Adaptation and prediction error responses are two components of neural processing related to […]
Kavli Affiliate: Jeremy Nathans | Authors: Jie Wang, Amir Rattner and Jeremy Nathans | Summary: Bacterial meningitis is a major cause of morbidity and mortality, especially among infants and the elderly. Here we study mice to assess the response of each of the major meningeal cell types to early postnatal E. coli infection using single […]
Kavli Affiliate: Denis Wirtzr | Authors:Adrian C. Johnston, Gretchen M. Alicea, Cameron C. Lee, Payal V. Patel, Eban A. Hanna, Eduarda Vaz, Andre Forjaz, Zeqi Wan, Praful R. Nair, Yeongseo Lim, Tina Chen, Wenxuan Du, Dongjoo Kim, Tushar D. Nichakawade, Vito W. Rebecca, Challice L. Bonifant, Rong Fan, Ashley L. Kiemen, Pei-Hsun Wu and Denis […]
Kavli Affiliate: Michael Beer | Authors: David Yao, Josh Tycko, Woo Oh, Lexi R. Bounds, Sager J. Gosai, Lazaros Lataniotis, Ava Mackay-Smith, Benjamin R. Doughty, Idan Gabdank, Henri Schmidt, Ingrid Youngworth, Kalina Andreeva, Xingjie Ren, Alejandro Barrera, Yunahi Luo, Keith Siklenka, Galip Gurkan Yardimci, The ENCODE4 Consortium, Ryan Tewhey, Anshul Kundaje, William J. Greenleaf, Pardis […]
Kavli Affiliate: Seth Blackshaw | Authors: Cornelia Peterson, Clayton P. Santiago, Yuchen Lu, Antoinette Price, Minda M. McNally, William Schubert, Seth Blackshaw, Charles G. Eberhart and Mandeep S. Singh | Summary: SUMMARY Purpose Proliferative vitreoretinopathy (PVR) is the most common cause of failure of surgically repaired rhegmatogenous retinal detachment (RRD). Chemically-induced and cell-injection PVR models […]
Kavli Affiliate: Patrick Kanold | Authors: Ji Liu and Patrick O Kanold | Summary: SUMMARY Predictive coding theory postulates that the brain achieves perception by actively making predictions about the incoming sensory information and correcting them if errors signals arise. These signals are likely the most relevant when the individual is actively interacting with the […]
Kavli Affiliate: Jeremiah Cohen | Authors: Zhixiao Su and Jeremiah Y. Cohen | Summary: Abstract The cerebral cortex generates flexible behavior by learning. Reinforcement learning is thought to be driven by error signals in midbrain dopamine neurons. However, they project more densely to basal ganglia than cortex, leaving open the possibility of another source of […]
Kavli Affiliate: Patrick Kanold | Authors: Ji Liu, Kate Maximov and Patrick O Kanold | Summary: Abstract Many animal training paradigms rely on head-fixation. Head-fixation training is typically laborious and can benefit from automation to relieve the workload as well as to reduce the variability in the training outcome. Several groups have reported successful implementations […]
Kavli Affiliate: Carey Priebe, Joshua Vogelstein | Authors: Benjamin D. Pedigo, Mike Powell, Eric W. Bridgeford, Michael Winding, Carey E. Priebe and Joshua T. Vogelstein | Summary: Abstract Comparing connectomes can help explain how neural connectivity is related to genetics, disease, development, learning, and behavior. However, making statistical inferences about the significance and nature of […]
Kavli Affiliate: Paul Greengard | Authors: Ran Zhang, Margarete Knudsen, Pedro Del Cioppo Vasques, Alicja Tadych, Patricia Rodriguez-Rodriguez, Paul Greengard, Jean-Pierre Roussarie, Ana Milosevic and Olga G. Troyanskaya | Summary: Abstract Astrocytes have been shown to play a central role in Alzheimer’s Disease (AD). However, the genes and biological pathways underlying disease manifestation are unknown, […]