Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Kavli Affiliate: Michael Goldberg | Authors: Saeko Takada, Bonnie J. Bolkan, MaryJane O’Connor, Michael Goldberg and Michael B. O’Connor | Summary: Toys are us (Trus) is the Drosophila ortholog of mammalian Programmed Cell Death 2-Like (PDCD2L), a protein that has been implicated in ribosome biogenesis, cell cycle regulation, and oncogenesis. In this study, we examined […]


Continue.. Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Kavli Affiliate: Sarah Woolley | Authors: Isabella Catalano and Sarah C Woolley | Summary: Social and sensory experiences across the lifespan can shape social interactions, however, experience-dependent plasticity is widely studied within discrete life stages. In the socially monogamous zebra finch, in which females use learned vocal signals to identify individuals and form long-lasting pair […]


Continue.. Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

Kavli Affiliate: Liam Paninski | Authors: Marcus A Triplett, Marta Gajowa, Benjamin Antin, Masato Sadahiro, Hillel Adesnik and Liam Paninski | Summary: Discovering how neural computations are implemented in the cortex at the level of monosynaptic connectivity requires probing for the existence of synapses from possibly thousands of presynaptic candidate neurons. Two-photon optogenetics has been […]


Continue.. Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

Modular representations emerge in neural networks trained to perform context-dependent tasks

Kavli Affiliate: Stefano Fusi | Authors: W. Jeffrey Johnston and Stefano Fusi | Summary: The brain has a well-known large scale organization at the level of brain regions, where different regions have been argued to primarily serve different behavioral functions. This regional specialization has been explained theoretically as arising from constraints on connectivity and the […]


Continue.. Modular representations emerge in neural networks trained to perform context-dependent tasks

3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Kavli Affiliate: Aniruddha Das | Authors: Jacqueline Salotti, Nida Asif, Srikanta Basu, Aniruddha Das, Mei Yang, Baktiar Karim, Karen Saylor, Nancy Martin, David A Scheiblin, Sweta Misra, Brian Luke, Thorkell Andresson, Stephen Lockett, Lino Tessarollo and Peter F Johnson | Summary: C/EBPβ is a potent regulator of oncogene-induced senescence (OIS) and the SASP. C/EBPβ is […]


Continue.. 3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Exploiting correlations across trials and behavioral sessions to improve neural decoding

Kavli Affiliate: Liam Paninski | Authors: Yizi Zhang, Hanrui Lyu, Cole Hurwitz, Shuqi Wang, Charles Lincoln Findling, Felix Hubert, Alexandre Pouget, International Brain Laboratory, Erdem Varol and Liam Paninski | Summary: Traditional neural decoders model the relationship between neural activity and behavior within individual trials of a single experimental session, neglecting correlations across trials and […]


Continue.. Exploiting correlations across trials and behavioral sessions to improve neural decoding

Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Kavli Affiliate: Stefano Fusi and Michael Goldberg | Authors: Anna Ipata, Valeria Fascianelli, Chris I De Zeeuw, Naveen Sendhilnathan, Stefano Fusi and Michael E. Goldberg | Summary: Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses […]


Continue.. Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

Kavli Affiliate: Attila Losonczy | Authors: Jingcheng Shi, Boaz Nutkovich, Dahlia Kushinsky, Bovey Y Rao, Stephanie A Herrlinger, Tiberiu S Mihaila, Katayun Cohen-Kashi Malina, Cliodhna K OToole, Margaret E Conde Paredes, Hyun C Yong, Erdem Varol, Attila Losonczy and Ivo Spiegel | Summary: Neural circuits are characterized by genetically and functionally diverse cell types. A […]


Continue.. 2P-NucTag: on-demand phototagging for molecular analysis of functionally identified cortical neurons

A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree

Kavli Affiliate: Michael Goldberg | Authors: David Porubsky, Harriet Dashnow, Thomas A. Sasani, Glennis A. Logsdon, Pille Hallast, Michelle D. Noyes, Zev N. Kronenberg, Tom Mokveld, Nidhi Koundinya, Cillian Nolan, Cody J. Steely, Andrea Guarracino, Egor Dolzhenko, William T. Harvey, William J. Rowell, Kirill Grigorev, Thomas J. Nicholas, Keisuke K. Oshima, Jiadong Lin, Peter Ebert, […]


Continue.. A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree

Telomere-to-telomere sheep genome assembly reveals new variants associated with wool fineness trait

Kavli Affiliate: Wei Min | Authors: Ling-Yun Luo, Hui Wu, Li-Ming Zhao, Ya-Hui Zhang, Jia-Hui Huang, Qiu-Yue Liu, Hai-Tao Wang, Dong-Xin Mo, He-Hua EEr, Lian-Quan Zhang, Hai-Liang Chen, Shan-Gang Jia, Wei-Min Wang and Meng-Hua Li | Summary: Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a […]


Continue.. Telomere-to-telomere sheep genome assembly reveals new variants associated with wool fineness trait