Kavli Affiliate: Stefano Fusi | Authors: Lorenzo Posani, Shuqi Wang, Samuel Muscinelli, Liam Paninski and Stefano Fusi | Summary: A long-standing debate in neuroscience concerns whether individual neurons are organized into functionally distinct populations that encode information differently (“categorical” representations [1–3]) and the implications for neural computation. Here, we systematically analyzed how cortical neurons encode […]

Kavli Affiliate: Scott Small | Authors: Clara T Rehmann, Scott T Small, Peter L Ralph and Andrew D. Kern | Summary: As organisms adapt to environmental changes, natural selection modifies the frequency of non-neutral alleles. For beneficial mutations, the outcome of this process may be a selective sweep, in which an allele rapidly increases in […]

Kavli Affiliate: Aniruddha Das | Authors: Aniruddha Das, Julie Borovicka, Hale Tobin, Shruti Bhatia, Jacob Icardi, Ghazaal Tahmasebi, Priyanka Agochiya, Shriya Singh, Bruce Trapp and Hod Dana | Summary: Damage to the myelin sheath that protects axons in the central nervous system is a hallmark pathology of demyelinating diseases like multiple sclerosis. Cuprizone-induced demyelination in […]

Kavli Affiliate: Michael Shadlen | Authors: Ariel Zylberberg and Michael N Shadlen | Summary: Confidence in a decision is the belief, prior to feedback, that one’s choice is correct. In the brain, many decisions are implemented as a race between competing evidence-accumulation processes. We ask whether the neurons that represent evidence accumulation also carry information […]

Kavli Affiliate: Kenneth Miller | Authors: Mauro M. Monsalve-Mercado and Kenneth D Miller | Summary: How do populations of neurons collectively encode and process information during cognitive tasks? We analyze high-yield population recordings from the macaque lateral intraparietal area (LIP) during a reaction-time random-dot-motion direction-discrimination task. We find that the trajectories of neural population activity […]

Kavli Affiliate: Kenneth Miller | Authors: Ho Yin Chau, Kenneth D Miller and Agostina Palmigiano | Summary: What are the principles that govern the responses of cortical networks to their inputs and the emergence of these responses from recurrent connectivity? Recent experiments have probed these questions by measuring cortical responses to two-photon optogenetic perturbations of […]

Kavli Affiliate: Stefano Fusi and Kenneth Miller | Authors: Mario Dipoppa, Ramon Nogueira, Stéphane Bugeon, Yoni Friedman, Charu B. Reddy, Kenneth D. Harris, Dario L. Ringach, Kenneth D. Miller, Matteo Carandini and Stefano Fusi | Summary: Allogeneic stem cell transplant (alloSCT) for patients with relapsed/refractory chronic lymphocytic Sensory adaptation dynamically changes neural responses as a […]

Kavli Affiliate: Stefano Fusi | Authors: Nicholas Menghi, William Jeffrey Johnston, Simone Vigano’, Max Andreas Bosse Hinrichs, Burkhard Maess, Stefano Fusi and Christian F Doeller | Summary: The complexity of our environment poses significant challenges for adaptive behavior. Recognizing shared structures across tasks can theoretically improve learning through generalization. However, how such shared representations emerge […]

Kavli Affiliate: Richard Axel | Authors: Andrew Jacob Pixley Fink, Samuel Muscinelli, Shuqi Wang, Marcus I Hogan, Daniel Fine English, Richard Axel, Ashok Litwin-Kumar and Carl E. Schoonover | Summary: Organisms continually tune their perceptual systems to the features they encounter in their environment1–3. We have studied how ongoing experience reorganizes the synaptic connectivity of […]

Kavli Affiliate: Rui Costa | Authors: Sara Moberg, Michele Garibbo, Camille Mazo, Ariel Gilad, Dietmar Schmitz, Rui Ponte Costa, Matthew E Larkum and Naoya Takahashi | Summary: Adaptive behavior is critically dependent on associative learning, where environmental cues are linked with subsequent positive or negative outcomes. In mammals, primary neocortical sensory areas serve as pivotal […]