In vivo cell-type and brain region classification via multimodal contrastive learning

Kavli Affiliate: Liam Paninski | Authors: Han Yu, Hanrui Lyu, Ethan YiXun Xu, Charlie Windolf, Eric Kenji Lee, Fan Yang, Andrew M Shelton, Shawn Olsen, Sahar Minavi, Olivier Winter, The International Brain Laboratory, Eva L Dyer, Chandramouli Chandrasekaran, Nicholas A Steinmetz, Liam Paninski and Cole Hurwitz | Summary: Current electrophysiological approaches can track the activity […]


Continue.. In vivo cell-type and brain region classification via multimodal contrastive learning

Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

Kavli Affiliate: Michael Beer | Authors: Joseph F Hoff, Kirsty E Goudar, Michael Beer, Philip Hinchliffe, John M Shaw, Catherine L Tooke, Yuiko Takebayashi, Adrian J Mulholland, Christopher J Schofield and James Spencer | Summary: Carbapenemases, β-lactamases hydrolysing carbapenem antibiotics, severely challenge treatment of multi-drug resistant bacterial infections. OXA-48 is among the most widely disseminated […]


Continue.. Electrostatic interactions define nacubactam potency against OXA-48-like β-lactamases

behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

Kavli Affiliate: Attila Losonczy | Authors: Kyu Sang Han, Inbal B Sander, Jacqueline Kumer, Eric Preston Resnick, Clare Booth, Bartholomew Starich, Jeremy Walston, Ashley L Kiemen, Sashank Reddy, Corrine Joshu, Joel Sunshine, Denis Wirtz and Pei-Hsun Wu | Summary: Investigators conducting behavioral experiments often need precise control over the timing of the delivery of stimuli […]


Continue.. behaviorMate: An Intranet of Things Approach for Adaptable Control of Behavioral and Navigation-Based Experiments

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

Kavli Affiliate: Mark Ellisman | Authors: Song-Yi Lee, Heegwang Roh, David Gonzalez-Perez, Mason R Mackey, Keun-Young Kim, Daniel Hoces, Colleen McLaughlin, Stephen R Adams, Khanh Nguyen, David J Luginbuhl, Liqun Luo, Namrata Udeshi, Steven A Carr, Rogelio A Hernandez-Lopez, Mark Ellisman, Miguel Alcalde and Alice Y Ting | Summary: Enzymes that oxidize aromatic substrates have […]


Continue.. Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

A circuit model for transsaccadic space updating and mislocalization

Kavli Affiliate: Michael Goldberg | Authors: Xiao Wang, Sophia Tsien, Michael E. Goldberg, Mingsha Zhang and Ning Qian | Summary: We perceive a stable, continuous world despite drastic changes of retinal images across saccades. However, while persistent objects in daily life appear stable across saccades, stimuli flashed around saccades can be grossly mislocalized. We address […]


Continue.. A circuit model for transsaccadic space updating and mislocalization

Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Kavli Affiliate: Michael Goldberg | Authors: Saeko Takada, Bonnie J. Bolkan, MaryJane O’Connor, Michael Goldberg and Michael B. O’Connor | Summary: Toys are us (Trus) is the Drosophila ortholog of mammalian Programmed Cell Death 2-Like (PDCD2L), a protein that has been implicated in ribosome biogenesis, cell cycle regulation, and oncogenesis. In this study, we examined […]


Continue.. Drosophila Trus, the orthologue of mammalian PDCD2L, is required for proper cell proliferation, larval developmental timing, and oogenesis

Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Kavli Affiliate: Sarah Woolley | Authors: Isabella Catalano and Sarah C Woolley | Summary: Social and sensory experiences across the lifespan can shape social interactions, however, experience-dependent plasticity is widely studied within discrete life stages. In the socially monogamous zebra finch, in which females use learned vocal signals to identify individuals and form long-lasting pair […]


Continue.. Early auditory and adult mating experiences interact with singer identity to shape neural responses to song in female zebra finches

Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

Kavli Affiliate: Liam Paninski | Authors: Marcus A Triplett, Marta Gajowa, Benjamin Antin, Masato Sadahiro, Hillel Adesnik and Liam Paninski | Summary: Discovering how neural computations are implemented in the cortex at the level of monosynaptic connectivity requires probing for the existence of synapses from possibly thousands of presynaptic candidate neurons. Two-photon optogenetics has been […]


Continue.. Rapid learning of neural circuitry from holographic ensemble stimulation enabled by model-based compressed sensing

Modular representations emerge in neural networks trained to perform context-dependent tasks

Kavli Affiliate: Stefano Fusi | Authors: W. Jeffrey Johnston and Stefano Fusi | Summary: The brain has a well-known large scale organization at the level of brain regions, where different regions have been argued to primarily serve different behavioral functions. This regional specialization has been explained theoretically as arising from constraints on connectivity and the […]


Continue.. Modular representations emerge in neural networks trained to perform context-dependent tasks

3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells

Kavli Affiliate: Aniruddha Das | Authors: Jacqueline Salotti, Nida Asif, Srikanta Basu, Aniruddha Das, Mei Yang, Baktiar Karim, Karen Saylor, Nancy Martin, David A Scheiblin, Sweta Misra, Brian Luke, Thorkell Andresson, Stephen Lockett, Lino Tessarollo and Peter F Johnson | Summary: C/EBPβ is a potent regulator of oncogene-induced senescence (OIS) and the SASP. C/EBPβ is […]


Continue.. 3’UTR-directed, kinase proximal mRNA decay inhibits C/EBPβ phosphorylation/activation to suppress senescence in tumor cells