Kavli Affiliate: C. Daniel Salzman | Authors: David L Barack, Akram Bakkour, Daphna Shohamy and C Daniel Salzman | Summary: Abstract In the real world, making sequences of decisions to achieve goals often depends upon the ability to learn aspects of the environment that are not directly perceptible. Learning these so-called latent features requires seeking […]
Kavli Affiliate: Costa, Rui | Authors: Lina Marcela Carmona, Lin T Tun, An Kim, Rani Shiao, Michael D Kissner, Vilas Menon and Rui M Costa | Summary: ABSTRACT The primary motor cortex (M1) is a central hub for motor learning and execution, as it receives input from and broadcasts to a multitude of other motor […]
Kavli Affiliate: Costa, Rui | Authors: Jonathan C.Y. Tang, Vitor Paixao, Filipe Carvalho, Artur Silva, Andreas Klaus, Joaquim Alves da Silva and Rui M Costa | Summary: Abstract Animals exhibit a diverse behavioral repertoire when exploring new environments and can learn which actions or action sequences produce positive outcomes. Dopamine release upon encountering reward is […]
Kavli Affiliate: Liam Paninski | Authors: James Yu, Amin Nejatbakhsh, Mahdi Torkashvand, Sahana Gangadharan, Maedeh Seyedolmohadesin, Jinmahn Kim, Liam Paninski and Vivek Venkatachalam | Summary: Tracking body parts in behaving animals, extracting fluorescence signals from cells embedded in deforming tissue, and analyzing cell migration patterns during development all require tracking objects with partially correlated motion. […]
Kavli Affiliate: Costa, Rui | Authors: Riccardo Avvisati, Anna-Kristin Kaufmann, Callum J Young, Gabriella E Portlock, Sophie Cancemi, Rui Ponte Costa, Peter J Magill and Paul D Dodson | Summary: Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference between expected and actual outcomes. While this teaching signal is […]
Kavli Affiliate: Michael Goldberg | Authors: Mitchell R. Vollger, William S. DeWitt, Philip C. Dishuck, William T. Harvey, Xavi Guitart, Michael E. Goldberg, Allison Rozanski, Julian Lucas, Mobin Asri, The Human Pangenome Reference Consortium, Katherine M. Munson, Alexandra P. Lewis, Kendra Hoekzema, Glennis A. Logsdon, David Porubsky, Benedict Paten, Kelley Harris, PingHsun Hsieh and Evan […]
Kavli Affiliate: Daphna Shohamy | Authors: Jonathan Nicholas, Nathaniel Douglass Daw and Daphna Shohamy | Summary: A key question in decision making is how humans arbitrate between competing learning and memory systems to maximize reward. We address this question by probing the balance between the effects, on choice, of incremental trial-and-error learning versus episodic memories […]
Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Eric G Keeler | Summary: Magic angle spinning NMR rotating frame relaxation measurements provide a powerful experimental strategy to probe biomolecules dynamics, as is illustrated by numerous recent applications. We discuss experimental strategies for this class of experiments, with a particular focus on systems where […]
Kavli Affiliate: Minoree Kohwi | Authors: Gillie Benchorin, Maggie Jiaqi Li, Richard Jangwon Cho, Yuxin Hu and Minoree Kohwi | Summary: Neural progenitors transit through multiple competence states that restrict production of each neural cell type. In Drosophila neuroblasts, a timed genome reorganization relocates the cell fate gene, hunchback, to the nuclear periphery, terminating competence […]
Kavli Affiliate: Ann McDermott | Authors: Ann E McDermott and Gary Stanley Howarth II | Summary: The structure of the transmembrane domain of bacterial potassium channel KcsA has been extensively characterized, yet little information is available on the structure of its cytosolic N- and C-termini. This study presents high-resolution magic angle spinning (HR-MAS) and fractional […]