Kavli Affiliate: Mark Churchland | Authors: Sean M. Perkins, John P. Cunningham, Qi Wang and Mark M. Churchland | Summary: Decoders for brain-computer interfaces (BCIs) assume constraints on neural activity, chosen to reflect scientific beliefs while yielding tractable computations. We document how low tangling — a typical property of motor-cortex neural trajectories — yields unusual […]
Kavli Affiliate: Rafael Yuste | Authors: Justin Lines and Rafael Yuste | Summary: Neuronal ensembles, defined as groups of coactive neurons, dominate cortical activity and are causally related to perceptual states and behavior. Interestingly, ensembles occur spontaneously in the absence of sensory stimulation. To better understand the function of ensembles in spontaneous activity, we explored […]
Kavli Affiliate: Richard Axel | Authors: Moise Bonheur, Kurtis J. Swartz, Melissa G. Metcalf, Anna Zhukovskaya, Avirut Mehta, Kristin E. Connors, Julia G. Barasch, Xinke Wen, Andrew R. Jamieson, Kelsey C. Martin, Richard Axel and Daisuke Hattori | Summary: Neural activity is modulated over different timescales encompassing sub-seconds to days reflecting changes in external environment, […]
Kavli Affiliate: Stefano Fusi | Authors: David G. Lee, Caroline A. McLachlan, Ramon Nogueira, Osung Kwon, Alanna E. Carey, Garrett House, Gavin D. Lagani, Danielle LaMay, Stefano Fusi and Jerry L. Chen | Summary: Goal-directed tasks involve acquiring an internal model, known as a predictive map, of relevant stimuli and associated outcomes to guide behavior. […]
Kavli Affiliate: Richard Axel | Authors: Tessa G. Montague, Isabelle J. Rieth, Sabrina Gjerswold-Selleck, Daniella Garcia-Rosales, Sukanya Aneja, Dana Elkis, Nanyan Zhu, Sabrina Kentis, Frederick A. Rubino, Adriana Nemes, Katherine Wang, Luke A. Hammond, Roselis Emiliano, Rebecca A. Ober, Jia Guo and Richard Axel | Summary: The coleoid cephalopods (cuttlefish, octopus, and squid) are a […]
Kavli Affiliate: Liam Paninski, Nathaniel Sawtell | Authors: Dan Biderman, Matthew R Whiteway, Cole Hurwitz, Nicholas R Greenspan, Robert S Lee, Ankit Vishnubhotla, Michael Schartner, Julia M Huntenburg, Anup Khanal, Guido T Meijer, Jean-Paul Noel, Alejandro Pan-Vazquez, Karolina Z Socha, Anne E Urai, The International Brain Laboratory, Richard Warren, Dillon Noone, Federico Pedraja, John Cunningham, […]
Kavli Affiliate: Franck Polleux | Authors: Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Erik Bloss, Franck Polleux and Tommy L Lewis, Jr. | Summary: Neuronal mitochondria play important roles beyond ATP generation, including Ca2+ uptake, and therefore have instructive roles […]
Kavli Affiliate: Jacqueline Gottlieb | Authors: Michael Cohanpour, Mariam Aly and Jacqueline Gottlieb | Summary: Humans are immensely curious and motivated to reduce uncertainty. Inspired by studies of sensory uncertainty, we hypothesized that visual areas provide multivariate representations of uncertainty, which are read out by higher-order areas that encode confidence and, ultimately, translated into curiosity. […]
Kavli Affiliate: Attila Losonczy | Authors: Bert Vancura, Tristan Geiller and Attila Losonczy | Summary: Excitatory-inhibitory interactions structure recurrent network dynamics for efficient cortical computations. In the CA3 area of the hippocampus, recurrent circuit dynamics, including experience-induced plasticity at excitatory synapses, are thought to play a key role in episodic memory encoding and consolidation via […]
Kavli Affiliate: Liam Paninski | Authors: Charlie Windolf, Angelique C Paulk, Yoav Kfir, Eric Trautmann, Samuel Garcia, Domokos Meszéna, William Muñoz, Irene Caprara, Mohsen Jamali, Julien C Boussard, Ziv M Williams, Sydney S Cash, Liam Paninski and Erdem Varol | Summary: High-density electrophysiology probes have opened new possibilities for systems neuroscience in human and non-human […]