Kavli Affiliate: Steven Siegelbaum | Authors: Christos Panagiotis Lisgaras, Azahara Oliva, Sam Mckenzie, John LaFrancois, Steven A. Siegelbaum and Helen E. Scharman | Summary: Temporal lobe epilepsy (TLE) is characterized by spontaneous recurrent seizures, abnormal activity between seizures, and impaired behavior. CA2 pyramidal neurons (PNs) are potentially important because inhibiting them with a chemogenetic approach […]

Kavli Affiliate: Rene Hen | Authors: Sebnem N. Tuncdemir, Andres D. Grosmark, Hannah Chung, Victor M. Luna, Clay O. Lacefield, Attila Losonczy and Rene Hen | Summary: Abstract The hippocampal dentate gyrus (DG) exhibits a unique form of neural plasticity that results from continuous integration of adult born neurons, referred to as ‘adult neurogenesis’. Recent […]

Kavli Affiliate: Robert Hawkins | Authors: Wenchao Gu, Sijin Luozhong, Ketaki Londhe, Nadine Elkasri, Simian Cai, Robert Hawkins, Zhefan Yuan, Kai Su-Greene, Margaret Cruz, Yu-Wei Chang, Patrick McMullen, Chunyan Wu, Changwoo Seo, Akash Guru, Wenting Gao, Tara Sarmiento, Chris Schaffer, Nozomi Nishimura, Richard Cerione, Melissa Warden, Robert Langer and Shaoyi Jiang | Summary: Abstract Systemic […]

Kavli Affiliate: Attila Losonczy | Authors: John C Bowler and Attila Losonczy | Summary: Summary The entorhinal cortex (EC) is central to the brain’s navigation system. Its subregions are conventionally thought to compute dichotomous representations for spatial processing: medial entorhinal cortex (MEC) provides a global spatial map, while lateral entorhinal cortex (LEC) encodes specific sensory […]

Kavli Affiliate: Steven Siegelbaum | Authors: Tobias Bock, Eric W Buss, Olivia M Lofaro, Felix W Leroy, Bina Santoro and Steven A Siegelbaum | Summary: Abstract Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the cationic Ih current in neurons and regulate the excitability of neuronal networks. The function of HCN channels depends, in part, on their […]

Kavli Affiliate: Steven Siegelbaum | Authors: Alexander C Whitebirch, Anastasia Barnett, Bina Santoro, Helen E Scharfman and Steven A Siegelbaum | Summary: ABSTRACT A significant proportion of temporal lobe epilepsy (TLE) patients experience drug-resistant seizures associated with mesial temporal sclerosis, in which there is extensive cell loss in the hippocampal CA1 and CA3 subfields, with […]

Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Darian Hadjiabadi, Satoshi Terada, Ivan Soltesz and Attila Losonczy | Summary: Summary Memory consolidation assimilates recent experiences into long-term memory. This process requires the replay of learned sequences, though the content of these sequences remains controversial. Recent work has shown that the statistics of replay deviate from […]

Kavli Affiliate: Larry Abbott, Nathaniel Sawtell | Authors: Salomon Zev Muller, Larry F Abbott and Nathaniel B Sawtell | Summary: Abstract Homeostatic (anti-Hebbian) forms of synaptic are effective at eliminating “prediction errors” that signal the differences between predicted and actual sensory input. However, such mechanisms appear to preclude the possibility of transmitting the resulting predictions […]

Kavli Affiliate: Stefano Fusi | Authors: Valeria Fascianelli, Fabio Stefanini, Satoshi Tsujimoto, Aldo Genovesio and Stefano Fusi | Summary: Abstract Animals likely use a variety of strategies to solve laboratory tasks. Traditionally, combined analysis of behavioral and neural recording data across subjects employing different strategies may obscure important signals and give confusing results. Hence it […]

Kavli Affiliate: Costa, Rui | Authors: Paul Botros, Nuria Vendrell-Llopis, Rui Costa and Jose Carmena | Summary: Abstract Throughout learning, refinement of cortical activity in cortex, a process termed “credit assignment”, underlies the refinement of behavioral actions leading to reward. While previous research shows striatum’s role in linking behavior to reward, striatum’s role in linking […]