Kavli Affiliate: Jos Zwanikken | Summary:Transcription factor concentrations provide signals to cells that allow them to regulate gene expression to make correct cell fate decisions. Calculations for noise bounds in gene regulation suggest that clustering or cooperative binding of transcription factors decreases signal-to-noise ratios at binding sites. However, clustering of transcription factor molecules around binding […]
Continue.. Weak transcription factor clustering at binding sites can facilitate information transfer from molecular signals