BDNF and TRiC-inspired Reagents Rescue Cortical Synaptic Deficits in a Mouse Model of Huntington’s Disease

Kavli Affiliate: William Mobley | Authors: Yingli Gu, Alexander Pope, Charlene Smith-Geater, Christopher Carmona, Aaron Johnstone, Linda Shi, Xuqiao Chen, Sarai Santos, Claire C Bacon-Brenes, Thomas Shoff, Korbin M Kleczko, Judith Frydman, Leslie M Thompson, William C Mobley and Chengbiao Wu | Summary: Abstract Huntington’s disease (HD) results from a CAG repeat expansion in the […]


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The gate-tunable Josephson diode

Kavli Affiliate: L. P. Kouwenhoven | First 5 Authors: [#item_custom_name[1]], [#item_custom_name[2]], [#item_custom_name[3]], [#item_custom_name[4]], [#item_custom_name[5]] | Summary: Superconducting diodes are a recently-discovered quantum analogueue of classical diodes. The superconducting diode effect relies on the breaking of both time-reversal and inversion symmetry. As a result, the critical current of a superconductor can become dependent on the direction […]


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Ganymede MHD Model: Magnetospheric Context for Juno’s PJ34 Flyby

Kavli Affiliate: George Clark | First 5 Authors: [#item_custom_name[1]], [#item_custom_name[2]], [#item_custom_name[3]], [#item_custom_name[4]], [#item_custom_name[5]] | Summary: On June 7th, 2021 the Juno spacecraft visited Ganymede and provided the first in situ observations since Galileo’s last flyby in 2000. The measurements obtained along a one-dimensional trajectory can be brought into global context with the help of three-dimensional […]


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Threshold of Primordial Black Hole Formation against Velocity Dispersion in Matter-Dominated Era

Kavli Affiliate: Misao Sasaki | First 5 Authors: [#item_custom_name[1]], [#item_custom_name[2]], [#item_custom_name[3]], [#item_custom_name[4]], [#item_custom_name[5]] | Summary: We study the effects of velocity dispersion on the formation of primordial black holes~(PBHs) in a matter-dominated era. The velocity dispersion is generated through the nonlinear growth of perturbations and has the potential to impede the gravitational collapse and thereby […]


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Logarithmic Duality of the Curvature Perturbation

Kavli Affiliate: Misao Sasaki | First 5 Authors: [#item_custom_name[1]], [#item_custom_name[2]], [#item_custom_name[3]], [#item_custom_name[4]], [#item_custom_name[5]] | Summary: We study the comoving curvature perturbation $mathcal{R}$ in general single-field inflation models whose potential can be approximated by a piecewise quadratic potential $V(varphi)$ by using the $delta N$ formalism. We find a general formula for $mathcal{R}(deltavarphi)$, which consists of a […]


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Standing genetic variation and chromosome differences drove rapid ecotype formation in a major malaria vector

Kavli Affiliate: Scott Small | Authors: Scott T Small, Carlo Costantini, N’Fale Sagnon, Moussa W Guelbeogo, Scott J Emrich, Andrew D Kern, Michael C Fontaine and Nora J Besansky | Summary: Abstract Local adaptation results in the formation of ecotypes–conspecific groups with heritable differences that increase fitness to distinct environments. The adaptive significance of ecotypes […]


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Multiplexed and scalable cellular phenotyping toward the standardized three-dimensional human neuroanatomy

Kavli Affiliate: Nathaniel Heintz | Authors: Tatsuya C. Murakami and Nathaniel Heintz | Summary: Abstract The advent of three-dimensional histological methods has advanced studies of cellular-resolution anatomy of the brain. The use of whole-mount staining and tissue clearing has advanced systems-level identification of cells underlying brain functions in mouse models. However, application of these methods […]


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Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Kavli Affiliate: Jose Suarez Lopez | Authors: José Luis López, Nikolaos Pappas, Sanne WM Poppeliers, Juan J. Sanchez-Gil, Arista Fourie-Fouche, Ronnie de Jonge and Bas E. Dutilh | Summary: Abstract The structure and function of the root microbial community is shaped by plant root activity, enriching specific microbial taxa and functions from the surrounding soil […]


Continue.. Copiotrophs dominate rhizosphere microbiomes and growth rate potential is a major factor explaining the rhizosphere effect

Multiplexed selectivity screening of anti-GPCR antibodies

Kavli Affiliate: Thomas P. Sakmar | Authors: Leo Dahl, Ilana Kotliar, Annika Bendes, Tea Dodig-Crnkovic, Samuel Fromm, Arne Elofsson, Mathias Uhlen, Thomas P Sakmar and Jochen Schwenk | Summary: Abstract G protein-coupled receptors (GPCRs) control critical cellular signaling pathways. Therapeutic agents, such as antibodies (Abs), are being developed to modulate GPCR signaling pathways. However, validating […]


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X-ray Polarization Observations of BL Lacertae

Kavli Affiliate: Herman L. Marshall | First 5 Authors: [#item_custom_name[1]], [#item_custom_name[2]], [#item_custom_name[3]], [#item_custom_name[4]], [#item_custom_name[5]] | Summary: Blazars are a class of jet-dominated active galactic nuclei with a typical double-humped spectral energy distribution. It is of common consensus the Synchrotron emission to be responsible for the low frequency peak, while the origin of the high frequency […]


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