Kavli Affiliate: Birgitta Whaley | First 5 Authors: Liwen Ko, Robert L. Cook, K. Birgitta Whaley, , | Summary: We show that for a class of quantum light spectroscopy (QLS) experiments using n = 0,1,2,$cdots$ classical light pulses and an entangled photon pair (a biphoton state) where one photon acts as a reference without interacting […]
Kavli Affiliate: Eric D. Siggia | Authors: Teresa Krammer, Hannah Taylor Stuart, Elena Gromberg, Keisuke Ishihara, Manuela Melchionda, Jingkui Wang, Elena Costantini, Stefanie Lehr, Dillon Cislo, Laura Arbanas, Alexandra Hoermann, Ralph Alexander Neumueller, Nicola Elvassore, Eric Siggia, James Briscoe, Anna Kicheva and Elly Margaret Tanaka | Summary: Organoids can undergo pattern formation by spontaneously forming […]
Kavli Affiliate: Michael W. Young | Authors: Georgia F Papadaki, Claire H Woodward, Michael C Young, Trenton J Winters, George M Burslem and Nikolaos G Sgourakis | Summary: Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to the endoplasmic […]
Kavli Affiliate: Ali H. Brivanlou | Authors: Tiago L Laundos, Shu Li, Eric Cheang, Riccardo De Santis, Francesco M Piccolo and Ali H. Brivanlou | Summary: Huntington’s disease (HD) remains an incurable and fatal neurodegenerative disease long after CAG-expansion mutation in the huntingtin gene (HTT) was identified as the cause. The underlying pathological mechanism, whether […]
Kavli Affiliate: Philip Starr | Authors: Md Fahim Anjum, Clay Smyth, Derk-Jan Dijk, Philip Starr, Timothy Denison and Simon Little | Summary: Background: Sleep disturbance is a prevalent and highly disabling comorbidity in individuals with Parkinson’s disease (PD) that leads to worsening of daytime symptoms, accelerated disease progression and reduced quality of life. Objectives: We […]
Kavli Affiliate: David Linden | Authors: Daniel C de la Fuente, Claudia Tamburini, Emily Stonelake, William J Griffiths, Jeremy Hall, Michael J Owen, David E. J. Linden, Andrew Pocklington, Yuqin Wang and Meng Li | Summary: Dysregulation in neural progenitor proliferation and neuronal differentiation has been increasingly recognised as a common pathology in neural cells […]
Kavli Affiliate: Xiang Zhang | First 5 Authors: Gaotang Li, Marlena Duda, Xiang Zhang, Danai Koutra, Yujun Yan | Summary: Brain graphs, which model the structural and functional relationships between brain regions, are crucial in neuroscientific and clinical applications involving graph classification. However, dense brain graphs pose computational challenges including high runtime and memory usage […]
Kavli Affiliate: Jiansheng Chen | First 5 Authors: Jingyuan Zhu, Huimin Ma, Jiansheng Chen, Jian Yuan, | Summary: Denoising diffusion probabilistic models (DDPMs) have been proven capable of synthesizing high-quality images with remarkable diversity when trained on large amounts of data. Typical diffusion models and modern large-scale conditional generative models like text-to-image generative models are […]
Kavli Affiliate: Robert Hawkins | Authors: Kerriann K Badal, Abhishek Sadhu, Carrie McCracken, Bindu L Raveendra, Sebastian Lozano-Villada, Amol C Shetty, Phillip Gillette, Yibo Zhao, Dustin Stommes, Lynne A Fieber, Michael C Schmale, Anup Mahurkar, Robert D Hawkins and Sathyanarayanan V Puthanveettil | Summary: Molecular mechanisms underlying aging associated impairments in learning and long-term memory […]
Kavli Affiliate: Salvatore Vitale | First 5 Authors: Matthew Evans, Alessandra Corsi, Chaitanya Afle, Alena Ananyeva, K. G. Arun | Summary: Gravitational-wave astronomy has revolutionized humanity’s view of the universe, a revolution driven by observations that no other field can make. This white paper describes an observatory that builds on decades of investment by the […]