Cellular and Molecular Basis of Leptin Resistance

Kavli Affiliate: Jeffrey M. Friedman | Authors: Bowen Tan, Kristina Hedbacker, Leah Kelly, Zhaoyue Zhang, Ji-Dung Luo, Joshua D. Rabinowitz and Jeffrey M. Friedman | Summary: Obese humans and diet induced obese mice (DIO) have high leptin levels and fail to respond to the exogenous hormone suggesting that obesity is caused by leptin resistance, the […]


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A mathematical theory of relational generalization in transitive inference

Kavli Affiliate: Vincent Ferrera | Authors: Samuel Lippl, Kenneth Kay, Greg Jensen, Vincent P. Ferrera and L.F. Abbott | Summary: Humans and animals routinely infer relations between different items or events and generalize these relations to novel combinations of items (“compositional generalization”). This allows them to respond appropriately to radically novel circumstances and is fundamental […]


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Small extracellular vesicles promote stiffness-mediated metastasis

Kavli Affiliate: Denis Wirtz | Authors: Alexandra Sneider, Ying Liu, Bartholomew Starich, Wenxuan Du, Carolyn Marar, Najwa Faqih, Gabrielle E Ciotti, Joo Ho Kim, Sejal Krishnan, Salma Ibrahim, Muna Igboko, Alexus Locke, Daniel M Lewis, Hanna Hong, Michelle Karl, Raghav Vij, Gabriella C Russo, Praful R Nair, Estibaliz Gómez-de-Mariscal, Mehran Habibi, Arrate Munoz-Barrutia, Luo Gu, […]


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GOALS-JWST: The Warm Molecular Outflows of the Merging Starburst Galaxy NGC 3256

Kavli Affiliate: Claudio Ricci | First 5 Authors: Thomas Bohn, Hanae Inami, Aditya Togi, Lee Armus, Thomas S. -Y. Lai | Summary: We present James Webb Space Telescope (JWST) Integral Field Spectrograph observations of NGC 3256, a local infrared-luminous late-stage merging system with two nuclei roughly 1$;rm{kpc}$ apart, both of which have evidence of cold […]


Continue.. GOALS-JWST: The Warm Molecular Outflows of the Merging Starburst Galaxy NGC 3256

Continuous Bump Attractor Networks Require Explicit Error Coding for Gain Recalibration

Kavli Affiliate: James Knierim | Authors: Gorkem Secer, James J. Knierim and Noah J. Cowan | Summary: Representations of continuous variables are crucial to create internal models of the external world. A prevailing model of how the brain maintains these representations is given by continuous bump attractor networks (CBANs) in a broad range of brain […]


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Gene count normalization in single-cell imaging-based spatially resolved transcriptomics

Kavli Affiliate: Jean Fan | Authors: Lyla Atta, Kalen Clifton, Manjari Anant and Jean Fan | Summary: Recent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted genes and their locations in fixed tissues. Normalization of gene expression data is often needed to account for technical factors that may confound […]


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Multiple objects evoke fluctuating responses in several regions of the visual pathway

Kavli Affiliate: Winrich Freiwald | Authors: Meredith N Schmehl, Valeria C Caruso, Yunran Chen, Na Young Jun, Shawn M Willett, Jeff T Mohl, Douglas A Ruff, Marlene R Cohen, Akinori Ebihara, Winrich Freiwald, Surya T Tokdar and Jennifer M Groh | Summary: How neural representations preserve information about multiple stimuli is mysterious. Because tuning of […]


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A Genome-Wide Arrayed CRISPR Screen Reveals PLSCR1 as an Intrinsic Barrier to SARS-CoV-2 Entry

Kavli Affiliate: Jean-Laurent Casanova, Charles M. Rice | Authors: Jeremie Le Pen, Gabrielle Paniccia, Michael Bauer, H.-Heinrich Hoffmann, Volker Kinast, Marcela Moncada-Velez, Ana Pinharanda, Inna Ricardo-Lax, Ansgar F Stenzel, Edwin A Rosado-Olivieri, Alison W Ashbrook, Kenneth H Dinnon, William Doyle, Catherine Freije, Seon-Hui Hong, Danyel Lee, Tyler Lewy, Joseph M Luna, Avery Peace, Carltin Schmidt, […]


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Epitaxial rare-earth doped complex oxide thin films for infrared applications

Kavli Affiliate: Darrell G. Schlom | First 5 Authors: Mythili Surendran, Joshua Rollag, Christopher E. Stevens, Ching-Tai Fu, Harish Kumarasubramanian | Summary: Rare earth dopants are one of the most extensively studied optical emission centers for a broad range of applications such as laser optoelectronics, sensing, lighting, and quantum information technologies due to their narrow […]


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Designed spin-texture-lattice to control anisotropic magnon transport in antiferromagnets

Kavli Affiliate: Darrell G. Schlom | First 5 Authors: Peter Meisenheimer, Maya Ramesh, Sajid Husain, Isaac Harris, Hyeon Woo Park | Summary: Spin waves in magnetic materials are promising information carriers for future computing technologies due to their ultra-low energy dissipation and long coherence length. Antiferromagnets are strong candidate materials due, in part, to their […]


Continue.. Designed spin-texture-lattice to control anisotropic magnon transport in antiferromagnets