Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Posted by dbos Yale

Kavli Affiliate: Michael J Higley | Authors: Saroj Sah, Andrew D Sauerbeck, Jyoti Gupta, Dayana Pérez-Acuña, Jacob E Reiber, Dreson Russell, Thomas Goralski, Michael Henderson, Laura A Volpicelli-Daley, Michael J Higley, Terrance T Kummer and Thomas Biederer | Summary: α-Synuclein aggregates characterize α-synucleinopathies, including Parkinson’s disease and Dementia with Lewy bodies. A majority of people […]


Continue.. Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson′s disease

Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart

Posted by dbos Hopkins

Kavli Affiliate: Jean Fan | Authors: Yuening Liu, Annabelle M. Coles, Jonah Castiglione, Vijay Venu Thiyagarajan, Kalen Clifton, Deevanshu Goyal, Jerry Wu, Arlo Sheridan, Ana Vujic, Kristen M. Harris, Uri Manor, Talmo D. Pereira, Jean Fan, Richard T. Lee and Pallav Kosuri | Summary: Resilience to cardiac stress is essential for health, yet the relationship […]


Continue.. Spatial imprints of emergent cardiomyocyte states in the pressure-overloaded heart

Detection of persistent helium absorption in the 91bg-like type Ia Supernova 2022an

Posted by klaurent Peking

Kavli Affiliate: Subo Dong | Summary:We present optical and near-infrared observations of the fast-declining Type Ia supernova (SN Ia) 2022an. The photometric and spectroscopic properties identify it as a standard 91bg-like event; however, our data reveal a relatively narrow absorption feature with a full width at half maximum (FWHM) of 75 angstroms near $1.037,μ$m in […]


Continue.. Detection of persistent helium absorption in the 91bg-like type Ia Supernova 2022an

Uncovering and Shaping the Latent Representation of 3D Scene Topology in Vision-Language Models

Posted by klaurent Caltech

Kavli Affiliate: Wei Gao| Summary:Decades of cognitive science establish that humans navigate environments by forming cognitive maps, defined as allocentric and topology-preserving representations of 3D space. While modern Vision-Language Models (VLMs) demonstrate emergent spatial reasoning from 2D egocentric inputs, it remains unclear whether they construct an analogous 3D internal representation. In this paper, we demonstrate […]


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On the origin of the environmental step: A BayeSN view of the ZTF SN Ia DR2

Posted by klaurent Cambridge

Kavli Affiliate: Kaisey Mandel | Summary:Astrophysical variabilities of Type Ia supernovae (SNe Ia), such as their link with their birth environment, are now one of the leading sources of systematic uncertainties on the measurement of the dark energy equation-of-state parameter $w$. Population studies of SNe Ia, using large samples, give precious insights into these variabilities. […]


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The study of the circumnuclear environment of accreting supermassive black holes with realistic X-ray spectral models

Posted by klaurent Peking

Kavli Affiliate: Claudio Ricci | Summary:X-ray spectral modeling is a powerful tool for studying the immediate environment of accreting objects, including supermassive black holes. Several models, either phenomenological or physically driven, have been developed over the past decade to study X-ray spectra, delivering important insights into the properties of circumnuclear material of active galactic nuclei […]


Continue.. The study of the circumnuclear environment of accreting supermassive black holes with realistic X-ray spectral models

Colossal Magnetoresistance and Phonon Driven Exchange Dynamics in Eu$_5$Sn$_2$As$_6$

Posted by klaurent Berkeley

Kavli Affiliate: Joel Moore | Summary:The emergence of colossal magnetoresistance in a new generation of Eu$^2+$-based antiferromagnets is intriguing given stark contrasts to the archetypal perovskite manganites and doped Eu-chalcogenides. In this study the thermal conductivity and magnetostriction of Eu$_5$Sn$_2$As$_6$ — one such representative — have been measured to better understand the role of the […]


Continue.. Colossal Magnetoresistance and Phonon Driven Exchange Dynamics in Eu$_5$Sn$_2$As$_6$

Electrically controlled Heat Assisted Magnetic Recording in Intercalated 2D Magnets

Posted by klaurent Berkeley

Kavli Affiliate: James Analytis| Summary:The ever-increasing demand for fast, reliable, and energy-efficient information storage continues to push magnetic memory technologies toward their fundamental limits. Conventional scaling strategies, which rely on reducing bit size, inevitably run into the "magnetic recording trilemma," where signal-to-noise ratio, thermal stability, and writability cannot all be optimized simultaneously. Heat-assisted magnetic recording […]


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Spatial navigation through evolution: a single-cell atlas of the mammalian entorhinal cortex

Posted by dbos NTNU

Kavli Affiliate: Menno Witter | Authors: Dorottya M Ralbovszki, Jesse J Westfall, Yuki Mori, Stamatios A Tahas, Mads F Bertelsen, Irina Korshunova, Josefine Skov, Jan Gorodkin, Martin Hemberg, Ernst Stefan Seemann, Vanessa Hall, Menno Witter and Konstantin Khodosevich | Summary: Spatial navigation is a fundamental mammalian ability, supported by the entorhinal cortex (EC), a structurally […]


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Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease

Posted by dbos UCSD / Salk

Kavli Affiliate: Mark Ellisman | Authors: Zhaoqi Yan, Andrew S Mendiola, Kelli Lauderdale, Keun-Young Kim, Yu Yong, Kun Leng, Eric A Bushong, Renaud Schuck, Anke Meyer-Franke, Ayushi Agrawal, Michela Traglia, Natalie Gill, Reuben Thomas, Jonah N Keller, Nikolaos Karvelas, Miguel F Vasquez, Daniel C Ballard, Matthew Madany, Jeffrey Simms, Brandon Guo, Reshmi Tognatta, Maria del […]


Continue.. Resilience to neuronal hyperactivity and restoration of the neuroimmune interactome by blocking fibrin-induced microglia activation in Alzheimers disease