Kavli Affiliate: Alan David Kaplan | Authors: Arghamitra Talukder and Alan Kaplan | Summary: Genomic foundation models promise to infer regulatory consequences of genetic variants directly from DNA sequence, but how well these predictions translate to clinical utility remains unclear. To probe this question, we evaluate AlphaGenome (AG) for understanding amyotrophic lateral sclerosis (ALS) genetics […]
Continue.. Limitations of Genomic Foundation Models for Decoding Regulatory Mechanisms in ALS