Kavli Affiliate: Michael Miller
| Authors: MoTrPAC Study Group, Daniel H. Katz, Christopher A. Jin, Gina M. Many, Gregory R. Smith, Hasmik Keshishian, Natalie M. Clark, Gayatri Iyer, Cheehoon Ahn, Malene E. Lindholm, Tyler J. Sagendorf, David Amar, Jacob L. Barber, Anna R. Brandt, Paul M. Coen, Yongchao Ge, Patrick Hart, Fang-Chi Hsu, Byron C. Jaeger, David Jimenez-Morales, Damon T. Leach, D. R. Mani, Samuel Montalvo, Hanna Pincas, Prashant Rao, James A. Sanford, Kevin S. Smith, Nikolai G. Vetr, Joshua N. Adkins, Euan A. Ashley, Steven A. Carr, Michael E. Miller, Stephen B. Montgomery, Venugopalan D. Nair, Jeremy M. Robbins, Michael P. Snyder, Lauren M. Sparks, Russell Tracy, Martin J. Walsh, Matthew T. Wheeler, Ashley Y. Xia, Stuart C. Sealfon, Robert E. Gerszten, Scott Trappe, Charles F. Burant , Bret H. Goodpaster, Hiba Abou Assi, Mary Anne S. Amper, Brian J. Andonian, Isaac K. Attah, Alicia Belangee, Bryan C. Bergman, Daniel H. Bessesen, Sue C. Bodine, Gerard A. Boyd, Nicholas T. Broskey, Thomas W. Buford, Toby L. Chambers, Clarisa Chavez Martinez, Maria Chikina, Alex Claiborne, Zachary S. Clayton, Clary B. Clish, Katherine A. Collins-Bennett, Dan M. Cooper, Tiffany M. Cortes, Gary R. Cutter, Matthew Douglass, Sara E. Espinoza, Charles R. Evans, Facundo M. Fernandez, Johanna Y. Fleischman, Daniel E. Forman, Will A. Fountain, David A. Gaul, Catherine Gervais, Aaron H. Gouw, Kevin J. Gries, Marina A. Gritsenko, Fadia Haddad, Joshua R. Hansen, Trevor Hastie, Zhenxin Hou, Joseph A. Houmard, Kim M. Huffman, Ryan P. Hughes, Chelsea M. Hutchinson-Bunch, Olga Ilkayeva, John M. Jakicic, Catherine M. Jankowski, Pierre M. Jean-Beltran, Neil M. Johannsen, Johanna L. Johnson, Maureen T. Kachman, Erin E. Kershaw, Wendy M. Kohrt, William E. Kraus, Dillon J. Kuszmaul, Bridget Le ster, Minghui Lu, Colleen E. Lynch, Nada Marjanovic, Sandra T. May, Edward L. Melanson, Nikhil Milind, Matthew E. Monroe, Cristhian Montenegro, Ronald J. Moore, Kerrie L. Moreau, Nicolas Musi, Masatoshi Naruse, Christopher B. Newgard, Bradley C Nindl, German Nudelman, Nora-Lovette Okwara, Eric A. Ortlund, Vladislav A. Petyuk, Paul D. Piehowski, David Popoli, Wei-Jun Qian, Shlomit Radom-Aizik, Tuomo Rankinen, Abraham Raskind, Alexander Raskind, Blake B. Rasmussen, Ulrika Raue, Eric Ravussin, R. Scott Rector, W. Jack Rejeski, Joseph Rigdon, Stas Rirak, Ethan Robbins, Margaret Robinson, Kaitlyn R. Rogers, Renee J. Rogers, Jessica L. Rooney, Irene E. Schauer, Robert S. Schwartz, Courtney G. Simmons, Chad M. Skiles, Tanu Soni, Maja Stefanovic-Racic, Cynthia L. Stowe, Andrew M. Stroh, Yifei Sun, Kristen J. Sutton, Anna Thalacker-Mercer, Robert Tibshirani, Todd A. Trappe, Mital Vasoya, Caroline S. Vincenty, Elena Volpi, Alexandria Vornholt, Katie L. Whytock, Angela Wiggins, Yilin X ie, Gilhyeon Yoon, Jay Yu, Xuechen Yu, Elena Zaslavsky, Zidong Zhang, Bingqing Zhao and Jimmy Zhen
| Summary:
Regular physical activity represents one of the greatest mechanisms for maintaining human health, yet the underlying molecular transducers of these benefits remain incompletely understood. Multi-omic assays now provide new opportunities to study the coordinated molecular responses of body tissues to different exercise modalities. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to address this need by creating a molecular map of the response to physical activity. Described here is the first human cohort of MoTrPAC: sedentary adults enrolled prior to study suspension during the COVID-19 pandemic (N=175) randomized to either endurance or resistance exercise, or non-exercise control. From these participants, we detail their global acute molecular response in skeletal muscle, adipose tissue, and blood, integrated at multiple levels: tissue, exercise modality, timepoint, and omic category. These analyses characterize key molecular pathways, identify central regulators, and implicate novel candidate exerkines in mediating multi-organ exercise effects.