A molecular grammar for programmable multiphase protein-RNA vesicles

Posted by dbos UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Vysakh Ramachandran and Davit A Potoyan | Summary: Protein–RNA phase separation gives rise to biomolecular condensates with rich internal organization, yet the molecular rules that connect sequence-encoded interactions and composition to the emergent architecture of these condensates remain poorly defined. Here, using large-scale residue-level coarse-grained simulations, we identify […]


Continue.. A molecular grammar for programmable multiphase protein-RNA vesicles

Individualized network topography in pre-adolescent children and adults using naturalistic precision fMRI

Posted by dbos UCSD / Salk

Kavli Affiliate: Deanna J. Greene | Authors: Shefali Sanjana Rai, Kate J. Godfrey, Kirk Graff, Ryann Tansey, Daria Merrikh, Shelly Yin, Matthew Feigelis, Damion Demeter, Tamara Vanderwal, Deanna J. Greene and Signe L. Bray | Summary: Group-averaged network definitions, commonly used in developmental functional connectivity research, limit our understanding of how network topography may change […]


Continue.. Individualized network topography in pre-adolescent children and adults using naturalistic precision fMRI

Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic Cancer

Posted by dbos Hopkins

Kavli Affiliate: Denis Wirtz | Authors: André Forjaz, Hengameh Mojdeganlou, Alens Valentin, Meredith Wetzel, Dmitrijs Lvovs, Atul Deshpande, Sarah M Shin, Sujan Piya, Kimal I Rajapakshe, Paola A Guerrero, Brian A Pedro, Dimitrios N Sidiropoulos, Pei-Hsun Wu, Vincent Bernard Pagan, Demystifying Pancreatic Cancer Therapies TeamLab, Denis Wirtz, Elana J Fertig, Luciane T Kagohara, Won Jin […]


Continue.. Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic Cancer

Loss of interruption in the HTT CAG repeat is associated with increased somatic expansion and loss of medium spiny neurons in HD

Posted by dbos Rockefeller

Kavli Affiliate: Nathaniel Heintz | Authors: Chris Kay, Jessica Dawson, Kert Mätlik, Hailey Findlay Black, Emily Harvey, Stephanie Bortnick, Kyla Javier, Christina Buchanan, Tanu Soomarooah, Inês Caldeira Brás, Glen Sequiera, Mahmoud Pouladi, Larissa Arning, Hoa HP Nguyen, Richard Roxburgh, Maurice Curtis, Richard LM Faull, Nathaniel Heintz and Michael R Hayden | Summary: Synonymous loss of […]


Continue.. Loss of interruption in the HTT CAG repeat is associated with increased somatic expansion and loss of medium spiny neurons in HD

Sequential sampling from memory underlies perceptual decisions unyoked from actions

Posted by dbos Columbia

Kavli Affiliate: Michael Shadlen | Authors: Prayshita Sharma, Michael Shadlen and S Shushruth | Summary: Perceptual decision-making refers to the class of decisions in which sensory evidence is used to categorize percepts and guide actions. Conventionally, categorical decisions are thought to precede motor actions. However, recent studies in nonhuman primates challenge this assumption – when […]


Continue.. Sequential sampling from memory underlies perceptual decisions unyoked from actions

Identification of the I$_10$ Donor in ZnO as a Sn–Li Complex with Large Hyperfine Interaction

Posted by klaurent Caltech

Kavli Affiliate: Joseph Falson | Summary:Donor impurities in wide direct band gap semiconductors provide a promising platform for spin–photon quantum technologies by combining a donor spin qubit with optically addressable transitions. In ZnO, the shallow donor with the largest reported binding energy has long been associated with the I$_10$ bound exciton line, but its microscopic […]


Continue.. Identification of the I$_10$ Donor in ZnO as a Sn–Li Complex with Large Hyperfine Interaction

PromptTuner: SLO-Aware Elastic System for LLM Prompt Tuning

Posted by klaurent Caltech

Kavli Affiliate: Wei Gao| Summary:Prompt tuning has become a prominent strategy for enhancing the performance of Large Language Models (LLMs) on downstream tasks. Many IT enterprises now offer Prompt-Tuning-as-a-Service to fulfill the growing demand for prompt tuning LLMs on downstream tasks. Their primary objective is to satisfy users Service Level Objectives (SLOs) while reducing resource […]


Continue.. PromptTuner: SLO-Aware Elastic System for LLM Prompt Tuning

Single-Particle Resonant States in Relativistic Hartree-Fock Theory: A Green’s Function Approach

Posted by klaurent Caltech

Kavli Affiliate: Wei Gao| Summary:Relativistic Hartree-Fock theory is combined with the Green’s function method in coordinate space to study both single-particle bound and resonant states within a unified framework. Within this approach, single-particle resonance energies and widths are unambiguously extracted from the density of states, and the influence of the Coulomb exchange effects on proton […]


Continue.. Single-Particle Resonant States in Relativistic Hartree-Fock Theory: A Green’s Function Approach