Kavli Affiliate: Lihong V. Wang
| First 5 Authors: Yang Zhang, Joshua Olick-Gibson, Karteekeya Sastry, Lihong V. Wang,
| Summary:
Optical imaging of blood flow yields critical functional insights into the
circulatory system, but its clinical implementation has typically been limited
to shallow depths (~1 millimeter) due to light scattering in biological tissue.
Here, we present photoacoustic noninvasive Doppler angiography (PANDA) for deep
blood flow imaging. PANDA synergizes the photoacoustic and Doppler effects to
generate color Doppler velocity and power Doppler blood flow maps of the
vascular lumen. Our results demonstrate PANDA’s ability to measure blood flow
in vivo up to one centimeter in depth, marking approximately an order of
magnitude improvement over existing high-resolution pure optical modalities.
PANDA enhances photoacoustic flow imaging by increasing depth and enabling
cross-sectional blood vessel imaging. We also showcase PANDA’s clinical
feasibility through three-dimensional imaging of blood flow in healthy subjects
and a patient with varicose veins. By integrating the imaging system onto a
mobile platform, we have designed PANDA to be a portable modality that is
primed for expedient clinical translation. PANDA offers noninvasive, single
modality imaging of hemoglobin and blood flow with three-dimensional
capability, facilitating comprehensive assessment of deep vascular dynamics in
humans.
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