Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Posted by dbos Yale

Kavli Affiliate: Flora Vaccarino | Authors: Soraya Scuderi, Tae-Yun Kang, Alexandre Jourdon, Liang Yang, Feinan Wu, Alex Nelson, George M. Anderson, Jessica Mariani, VIVEKANANDA SARANGI, Alexej Abyzov, Andre Levchenko and Flora M. Vaccarino | Summary: The repertory of neurons generated by progenitor cells depends on their location along antero-posterior and dorso-ventral axes of the neural […]


Continue.. Specification of human regional brain lineages using orthogonal gradients of WNT and SHH in organoids

Differential Control of Inhibitory and Excitatory Nerve Terminal Function by Mitochondria

Posted by dbos Rockefeller

Kavli Affiliate: Timothy A. Ryan | Authors: Kirsten Bredvik and Timothy A Ryan | Summary: Inhibitory neurons shape the brain’s computational landscape and rely on different cellular architectures and intrinsic properties than excitatory neurons. Maintenance of the overall balance of excitatory (E) versus inhibitory (I) drive is essential, as disruptions can lead to neuropathological conditions, […]


Continue.. Differential Control of Inhibitory and Excitatory Nerve Terminal Function by Mitochondria