Comparative analysis of single-cell and single-nucleus RNA-sequencing in a rabbit model of retinal detachment-related proliferative vitreoretinopathy.

Posted by klaurent Hopkins

Kavli Affiliate: Seth Blackshaw | Authors: Clayton P. Santiago, Megan Y. Gimmen, Yuchen Lu, Minda M. McNally, Leighton H. Duncan, Tyler Creamer, Linda Orzolek, Seth Blackshaw and Mandeep Singh | Summary: Structured Abstract Purpose Proliferative vitreoretinopathy (PVR) is the most common cause of failure of retinal reattachment surgery and the molecular changes leading to this […]


Continue.. Comparative analysis of single-cell and single-nucleus RNA-sequencing in a rabbit model of retinal detachment-related proliferative vitreoretinopathy.

Structured Joint Decomposition (SJD) identifies conserved molecular dynamics across collections of biologically related multi-omics data matrices

Posted by klaurent Hopkins

Kavli Affiliate: Brian Caffo | Authors: Huan Chen, Jinrui Liu, Shreyash Sonthalia, Genevieve Stein-OBrien, Luo Xiao, Brian Caffo and Carlo Colantuoni | Summary: Abstract Motivation It is necessary to develop exploratory tools to learn from the unprecedented volume of high-dimensional multi-omic data currently being produced. We have developed an R package, SJD, which identifies components […]


Continue.. Structured Joint Decomposition (SJD) identifies conserved molecular dynamics across collections of biologically related multi-omics data matrices

Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Paul L. Auer, Yasminka A Jakubek, Ying Zhou, Adrienne M Stilp, Jason Bacon, Justin Wong, Braxton Mitchell, Joshua Lewis, Eric Boerwinkle, Ruth J.F. Loos, Michael Preuss, Kathleen Barnes, Nathan Pankratz, Myriam Fornage, Susan Redline, Bruce M. Psaty, Joshua C. Bis, Edwin Silverman, Michael Cho, Jeong Yun, Vasan Ramachandran, […]


Continue.. Mosaic chromosomal alterations in blood across ancestries via whole-genome sequencing

The giant low surface brightness galaxy Malin 1: new constraints for its molecular gas mass from GBT/ARGUS observations

Posted by klaurent Stanford

Kavli Affiliate: Sarah Church | Summary:We report on results from GBT/ARGUS $^12$CO(1-0) observations for the giant low surface brightness galaxy Malin 1, which allow us to determine an upper limit for its CO mass, and hence its molecular gas mass and molecular gas mass surface density $Σ_H_2$. Although we performed very deep observations through 17 […]


Continue.. The giant low surface brightness galaxy Malin 1: new constraints for its molecular gas mass from GBT/ARGUS observations

Photon shot-noise limited transient absorption soft X-ray spectroscopy at the European XFEL

Posted by klaurent Chicago

Kavli Affiliate: Robert Rosner| First 5 Authors: Loïc Le Guyader, Loïc Le Guyader, , , | Summary:Femtosecond transient soft X-ray Absorption Spectroscopy (XAS) is a very promising technique that can be employed at X-ray Free Electron Lasers (FELs) to investigate out-of-equilibrium dynamics for material and energy research. Here we present a dedicated setup for soft […]


Continue.. Photon shot-noise limited transient absorption soft X-ray spectroscopy at the European XFEL

Generating counterfactual explanations of tumor spatial proteomes to discover effective strategies for enhancing immune infiltration

Posted by klaurent Caltech

Kavli Affiliate: Matt W. Thomson| Summary:The tumor microenvironment (TME) significantly impacts cancer prognosis due to its immune composition. While therapies for altering the immune composition, including immunotherapies, have shown exciting results for treating hematological cancers, they are less effective for immunologically-cold, solid tumors. Spatial omics technologies capture the spatial organization of the TME with unprecedented […]


Continue.. Generating counterfactual explanations of tumor spatial proteomes to discover effective strategies for enhancing immune infiltration

Single-Photon Signal Sideband Detection for High-Power Michelson Interferometers

Posted by klaurent MIT

Kavli Affiliate: Lee McCuller | Summary:The Michelson interferometer is a cornerstone of experimental physics. Its applications range from providing first impressions of wave interference in educational settings to probing spacetime at minuscule precision scales. Interferometer precision provides a unique view of the fundamental medium of matter and energy, enabling tests for new physics as well […]


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Entanglement Dynamics of the Non-Unitary Holographic Channel

Posted by klaurent UCAS

Kavli Affiliate: Masahiro Nozaki | First 5 Authors: Kanato Goto, Masahiro Nozaki, Kotaro Tamaoka, Mao Tian Tan, | Summary: We study the dynamical properties of a strongly scrambling quantum circuit involving a projective measurement on a finite-sized region by studying the operator entanglement entropy and mutual information (OEE and BOMI) of the dual operator state […]


Continue.. Entanglement Dynamics of the Non-Unitary Holographic Channel