Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Keri Martinowich | Authors: Alexa F Iannitelli, Leslie Hassanein, Bernard Mulvey, Harris Blankenship, L Cameron Liles, Amanda L Sharpe, Jean-Francois Pare, Arielle Segal, Steven A Sloan, Keri Martinowich, Katharine E McCann, Joseph D Dougherty, Yoland Smith, Michael J Beckstead and David Weinshenker | Summary: The locus coeruleus (LC), the major source of norepinephrine […]


Continue.. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus

Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency

Posted by dbos Rockefeller, This Week: Neuroscience

Kavli Affiliate: Robert B. Darnell | Authors: Maria Skamagki, Cheng Zhang, Ezgi Hacisuleyman, Giuseppe Galleti, Chao Wu, Rajasekhar K Vinagolu, HyoKyeong Cha, Deniz Ata, Jongjin Kim, Taylor Weiskittel, Mame Diop, Thiri Aung, Michael Del Latto, Amanda S. Kim, Zhuoning Li, Matthew Miele, Rui Zhao, Laura H. Tang, Ronald C. Hendrickson, Paul B. Romesser, Jesse Joshua […]


Continue.. Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency

Measuring the functional complexity of nanoscale connectomes: polarity matters

Posted by dbos Hopkins, This Week: Neuroscience

Kavli Affiliate: Carey Priebe and Joshua Vogelstein | Authors: Qingyang Wang, Nadine Randel, Yijie Yin, Cameron Shand, Amy Strange, Michael Winding, Albert Cardona, Marta Zlatic, Joshua Vogelstein and Carey Priebe | Summary: The emerging electron microscopy connectome datasets provides connectivity maps of the brains at single cell resolution, enabling us to estimate various network statistics, […]


Continue.. Measuring the functional complexity of nanoscale connectomes: polarity matters