Kavli Affiliate: Michael Miller | Authors: Lei Liu, Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean-Pierre Bellier, Han-Bin Yoo, Andrea Roman, Elizabeth L Hennessey, Samadhi Wijethunga, Elif Lara Okyay, Michael B Miller, Hyun-Sik Yang, Dennis J Selkoe and Jasmeer Chhatwal | Summary: Background Alternative splicing of the MAPT gene produces distinct tau isoforms in […]
Kavli Affiliate: Michela Gallagher | Authors: Rebecca P. Haberman, Ana Delgado, Meifang Xiao, Ming Teng Koh, Ashley A Becker, Shiyu Ji, Paul F Worley, Michela Gallagher and Audrey E. Branch | Summary: Changes in synaptic integrity and neural activity homeostasis are hallmarks of brain aging and are closely tied to cognitive outcomes. Yet, defining their […]
Kavli Affiliate: Loren Frank | Authors: Abhilasha Joshi, Alison E. Comrie, Samuel Bray, Abhijith Mankili, Jennifer A. Guidera, Rhino Nevers, Xulu Sun, Emily Monroe, Viktor Kharazia, Ryan Ly, Daniela Astudillo Maya, Denisse Morales-Rodriguez, Jai Yu, Anna Kiseleva, Victor Perez and Loren M. Frank | Summary: The ability to rapidly learn and retrieve salient information about […]
Kavli Affiliate: Elizabeth Hillman | Authors: Mary Claire Tuohy, Ping-Chang Kuo, Adrian Chelminski, Eti Muharremi, Claudia DeSantis, Aomeng Cui, Alicia Russo, Danny Jamoul, Elizabeth Hillman, John F Crary, Jui-Hung Jimmy Yen and Dritan Agalliu | Summary: Vascular normalization [stabilization of aberrant angiogenesis and restoration of blood-brain barrier (BBB)] is critical for reducing long-term secondary sequelae […]
Kavli Affiliate: Emre Yaksi | Authors: Anh-Tuan Trinh, Anna Maria Ostenrath, Ignacio del Castillo-Berges, Susanne Kraus, Fanchon Cachin, Bram Serneels, Koichi Kawakami and Emre Yaksi | Summary: Thalamocortical projections contribute to the spatial organization and functional hierarchies of the mammalian cortex. Primary sensory cortices receive topographically segregated information from first-order thalamic nuclei, which process distinct […]
Kavli Affiliate: Reza Shadmehr | Authors: Alkis M. Hadjiosif, Kahori Kita, Scott T. Albert, Robert A. Scheidt, Reza Shadmehr and John W. Krakauer | Summary: Moving and holding still have been posited to be under separate control regimes for both eye and arm movements. The paretic arm after stroke is notable for abnormalities both at […]
Kavli Affiliate: Robert Edwards | Authors: Vijini Mallawaarachchi, George Bouras, Ryan R. Wick, Susanna R. Grigson, Bhavya Papudeshi and Robert A. Edwards | Summary: Assembly graphs are a fundamental data structure used by genome and metagenome assemblers to represent sequences and their overlap information, facilitating the assembler to construct longer genomic fragments. Apart from their […]
Kavli Affiliate: Darcy Peterka and Michael Shadlen | Authors: Jia Shen, Nuttida Rungratsameetaweemana, Prayshita Sharma, Darcy S. Peterka, Herbert Zheng Wu and Michael N. Shadlen | Summary: Cognitive operations often require flexible implementation of stimulus–response contingencies, depending on context. We developed an olfactory task in which mice learned to associate a test odor with a […]
Kavli Affiliate: Rafael Yuste | Authors: Jason Ken Adhinarta, Yutian Fan, Adam Gohain, Michael Lin, Paige Nurkin, Richard Ren, Micaela Roth, Shulin Zhang, Ayal Yakobe, Rafael Yuste and Donglai Wei | Summary: Vesicles are critical components of neurons that package neurotransmitters and neuropeptides for their release, in order to communicate with other neurons and cells. […]
Kavli Affiliate: John Serences | Authors: Kirsten C.S. Adam, Edward Awh and John T. Serences | Summary: Increasing working memory (WM) load incurs behavioral costs, and whether the neural constraints on behavioral costs are localized (i.e., emanating from the intraparietal sulcus) or distributed across cortex remains an active area of debate. In a pre-registered fMRI […]