Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang | Authors: DANQING ZHU, David H Brookes, Akosua Busia, Ana Carneiro, Clara Fannjiang, Galina Popova, David Shin, Edward F Chang, Tomasz J. Nowakowski, Jennifer Listgarten and David V Schaffer | Summary: Abstract Adeno-associated viruses (AAVs) hold tremendous promise as delivery vectors for clinical gene therapy, but they need improvement. AAVs with […]


Continue.. Optimal trade-off control in machine learning-based library design, with application to adeno-associated virus (AAV) for gene therapy

Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus

Posted by klaurent UCSF

Kavli Affiliate: Arnold Kriegstein | Authors: Brian R Herb, Hannah J Glover, Aparna Bhaduri, Carlo Colantuoni, Tracy L Bale, Kimberly Siletti, Sten Linnarsson, Rebecca D Hodge, Ed Lein, Arnold Kriegstein, Claudia Doege and Seth A Ament | Summary: Abstract The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. We […]


Continue.. Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus

Heritable differences in synaptic zinc-transporter levels drive variation in learned birdsong

Posted by klaurent UCSF

Kavli Affiliate: Michael Brainard | Authors: DG. Mets, W. H. Mehaffey, B. M. Colquitt and M. S. Brainard | Summary: Abstract The authors have withdrawn this manuscript. During revision of our manuscript, we carried out several lines of additional experiments and analyses that failed to fully support and reproduce the results previously presented in Figure […]


Continue.. Heritable differences in synaptic zinc-transporter levels drive variation in learned birdsong

Phase alignment of low-frequency neural activity to the amplitude envelope of speech reflects evoked responses to acoustic edges, not oscillatory entrainment

Posted by klaurent UCSF

Kavli Affiliate: Edward Chang | Authors: Yulia Oganian, Katsuaki Kojima, Assaf Breska, Chang Cai, Anne Findlay, Edward F Chang and Srikantan Nagarajan | Summary: Abstract The amplitude envelope of speech is crucial for accurate comprehension. Considered a key stage in speech processing, the phase of neural activity in the theta-delta bands (1 – 10 Hz) […]


Continue.. Phase alignment of low-frequency neural activity to the amplitude envelope of speech reflects evoked responses to acoustic edges, not oscillatory entrainment