DNA Methylation Signatures in Breast Cancer: A Systematic Review and Meta-Analysis

Kavli Affiliate: Terrence Sejnowski | Authors: Antonio Pinto-Duarte, Katherine Bogue, Terrence J Sejnowski and Shyam Srinivasan | Summary: Abstract Epigenetic changes are involved in the onset and progression of cancer, and the detection of DNA methylation signatures may foster the improvement of diagnosis and prognosis. While the emergence of innovative technologies has fostered numerous studies […]


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Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus

Kavli Affiliate: Eran Mukamel | Authors: Matthew G Heffel, Jingtian Zhou, Yi Zhang, Dong-Sung Lee, Kangcheng Hou, Oier Pastor Alonso, Kevin Abuhanna, Anthony D Schmitt, Terence Li, Maximilian Haeussler, Brittney Wick, Martin Jinye Zhang, Fangming Xie, Ryan S Ziffra, Eran A Mukamel, Eleazar Eskin, Bogdan Pasaniuc, Joseph R. Ecker, Jesse Dixon, Tomasz J. Nowakowski, Mercedes […]


Continue.. Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus

Dopamine signaling regulates predator-driven behavioral changes in Caenorhabditis elegans

Kavli Affiliate: Sreekanth Chalasani | Authors: Amy Pribadi, Kaila Rosales, Kirthi C Reddy and Sreekanth H Chalasani | Summary: Abstract Prey respond to predators by altering their behavior to optimize their own fitness and survival. We probe the interactions between Caenorhabditis elegans and its naturally cohabiting predator Pristionchus uniformis to reveal the pathways driving changes […]


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Oscillations and aperiodic activity: Evidence for dynamic changes in both during memory encoding

Kavli Affiliate: Bradley Voytek | Authors: Michael Preston, Natalie Schaworonkow and Bradley Voytek | Summary: Abstract Electrical recordings of human brain activity via electroencephalography (EEG) show prominent, rhythmic voltage fluctuations. These periodic oscillations have been linked to nearly every cognitive and perceptual process, as well numerous disease states. Recent methodological and theoretical advances, however, have […]


Continue.. Oscillations and aperiodic activity: Evidence for dynamic changes in both during memory encoding

GESIAP: A Versatile Genetically Encoded Sensor-based Image Analysis Program

Kavli Affiliate: Fred Gage | Authors: W. Sharon Zheng, Yajun Zhang, Roger E. Zhu, Peng Zhang, Smriti Gupta, Limeng Huang, Deepika Sahoo, Kaiming Guo, Matthew E. Glover, Krishna C. Vadodaria, Mengyao Li, Tongrui Qian, Miao Jing, Jiesi Feng, Jinxia Wan, Philip M. Borden, Kaspar Podgorski, Farhan Ali, Alex C. Kwan, Li Gan, Li Lin, Fred […]


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Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Kavli Affiliate: Samuel Pfaff | Authors: Lydia Daboussi, Giancarlo Costaguta, Miriam Gullo, Veronica Pessino, Brendan O’Leary, Karen Lettieri, Shawn Driscoll and Samuel L. Pfaff | Summary: Abstract Schwann cells respond to acute axon damage by transiently transdifferentiating into specialized repair cells that restore sensorimotor function. However, the molecular systems controlling repair cell formation and function […]


Continue.. Mitf is a Schwann Cell Sensor of Axonal Integrity that Drives Nerve Repair

Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM

Kavli Affiliate: Mark Ellisman | Authors: Hugo Calligaro, Azarin Shoghi, Xinyue Chen, Keun-Young Kim, Yu Hsin Liu, Brian Khov, Benjamin Finander, Hiep Le, Mark H Ellisman and Satchidananda Panda | Summary: Abstract The suprachiasmatic nucleus (SCN) in the hypothalamus of the vertebrate brain is the central pacemaker regulating circadian rhythmicity throughout the body. The SCN […]


Continue.. Ultrastructure of synaptic connectivity within sub-regions of the SCN revealed by genetically encoded EM tag and SBEM

Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

Kavli Affiliate: Fred Gage | Authors: Sarah L Parylak, Fan Qiu, Sara B Linker, Iryna S Gallina, Christina K Lim, David Preciado, Aidan H McDonald and Fred H Gage | Summary: Abstract Immature dentate granule cells (DGCs) generated in the hippocampus during adulthood are believed to play a unique role in dentate gyrus function. Although […]


Continue.. Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells

Historical biogeography of Cannabis in the Iberian Peninsula: palynological evidence

Kavli Affiliate: Jose Suarez Lopez | Authors: Valenti Rull, Francesc Burjachs, Jose Carrion, Ana Ejarque, Santiago Fernandez, Jose Antonio Lopez-Saez, Reyes Luelmo-Lautenschlaeger, Juan Ochando, Sebastian Perez-Diaz, Jordi Revelles, Santiago Riera and Sara Rodriguez | Summary: Abstract The tempo and mode of colonization of the Iberian Peninsula (IP) by Cannabis sativa, its further internal spreading and […]


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Cortico-cortical and hippocampo-cortical co-rippling are facilitated by thalamo-cortical spindles and upstates, but not by thalamic ripples

Kavli Affiliate: Eric Halgren | Authors: Charles W Dickey, Ilya A Verzhbinsky, Sophie Kajfez, Burke Q Rosen, Sandipan Pati and Eric Halgren | Summary: Abstract The co-occurrence of brief ~90 Hz oscillations (co-ripples) may be important in integrating information across the cortex and hippocampus, essential for sleep consolidation, and cognition in general. However, how such […]


Continue.. Cortico-cortical and hippocampo-cortical co-rippling are facilitated by thalamo-cortical spindles and upstates, but not by thalamic ripples