Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Posted by klaurent UCSD / Salk

Kavli Affiliate: Anders Dale | Authors: Elleke Tissink, Alexey A Shadrin, Dennis van der Meer, Nadine Parker, Guy Hindley, Daniel Roelfs, Oleksandr Frei, Chun Chieh Fan, Mats Nagel, Terje Naerland, Magdalena Budisteanu, Srdjan Djurovic, Lars T. Westlye, Martijn van den Heuvel, Danielle Posthuma, Tobias Kaufmann, Anders M. Dale and Ole Andreassen | Summary: Genetic pleiotropy […]


Continue.. Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study

Estimating the Total Variance Explained by Whole-Brain Imaging for Zero-inflated Outcomes

Posted by klaurent UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Junting Ren, Robert John Loughnan, Bohan Xu, Wesley K. Thompson and Chun Chieh Fan | Summary: Zero-inflated outcomes are very common in behavioral data, particularly for responses to psychological questionnaires. Modeling these challenging distributions is further exacerbated by the absence of established statistical models capable of characterizing total signals […]


Continue.. Estimating the Total Variance Explained by Whole-Brain Imaging for Zero-inflated Outcomes

Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Posted by klaurent UCSD / Salk

Kavli Affiliate: Ethan Bier | Authors: Leonardo Lima, Mateus Berni, Jamile Mota, Daniel Bressan, Alison Julio, Robson Cavalcante, Vanessa Macias, Zhiqian Li, Jason L. Rasgon, Ethan Bier and Helena Marcolla Araujo | Summary: Rhodnius prolixus is currently the model vector of choice for studying Chagas disease transmission, a debilitating disease caused by Trypanosoma cruzi parasites. […]


Continue.. Gene editing in the Chagas disease vector Rhodnius prolixus by Cas9-mediated ReMOT Control

Xylem sap residue in cut-open conduits can affect gas discharge in pneumatic experiments

Posted by klaurent UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Marcela Trevenzoli Miranda, Luciano Pereira, Gabriel Silva Pires, Xinyi Guan, Luciano Melo Silva, Swetlana Kreinert, Eduardo Caruso Machado, Steven Jansen and Rafael Ribeiro | Summary: Considerable progress has been made in understanding the mechanisms of embolism formation based on the pneumatic method, which relies on gas discharge measurements. Here, […]


Continue.. Xylem sap residue in cut-open conduits can affect gas discharge in pneumatic experiments

A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Posted by klaurent Hopkins, UCSD / Salk

Kavli Affiliate: Wesley Thompson | Authors: Rong Zablocki, Bohan Xu, Chun-Chieh Fan and Wesley K. Thompson | Summary: Here we present a development of the novel Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC) model. BRAINIAC allows for both estimation of total variance explained by all features for a given cognitive phenotype, as well […]


Continue.. A Bayesian Regularized and Anotation-Informed Integrative Analysis of Cognition (BRAINIAC)

Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

Posted by klaurent UCSD / Salk

Kavli Affiliate: Andrea Hasenstaub | Authors: David A. McCormick, Yousheng Shu and Andrea R Hasenstaub | Summary: The ventral pallidum (VP) contains GABA and glutamate (Glut) neurons projecting to ventral tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet little is known about the cell-type-specific mechanisms by which VP projections to VTA drive […]


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Barley cultivars shape the abundance, phenotype, genotype and gene expression of their associated microbiota by differential root exudate secretion

Posted by klaurent UCSD / Salk

Kavli Affiliate: V. S. Ramachandran | Authors: Alba Pacheco-Moreno, Anita Bollmann-Giolai, Govind Chandra, Paul Brett, Jack Davies, Owen Thornton, Philip Poole, Vinoy Ramachandran, James Brown, Paul Nicholson, Chris Ridout, Sarah DeVos and Jacob G. Malone | Summary: Plant associated microbes play vital roles in promoting plant growth and health, with plants secreting root exudates into […]


Continue.. Barley cultivars shape the abundance, phenotype, genotype and gene expression of their associated microbiota by differential root exudate secretion

Mitochondria morphology governs ATP production rate

Posted by klaurent UCSD / Salk

Kavli Affiliate: Terrence Sejnowski | Authors: Guadalupe C. Garcia, Kavya Gupta, Thomas M. Bartol, Jr., Terrence J. Sejnowski and Padmini Rangamani | Summary: Life is based on energy conversion. In particular, in the nervous system significant amounts of energy are needed to maintain synaptic transmission and homeostasis. To a large extent, neurons depend on oxidative […]


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A unified framework to identify demographic buffering in natural populations

Posted by klaurent UCSD / Salk

Kavli Affiliate: Gabriel Silva | Authors: Gabriel Silva Santos, Samuel J L Gascoigne, Andre Tavares Correia Dias, Maja Kajin and Rob Salguero-Gomez | Summary: The Demographic Buffering Hypothesis (DBH) predicts that natural selection reduces the temporal fluctuations in demographic processes (such as survival, development, and reproduction), due to their negative impacts on population dynamics. However, […]


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Cognitive rehabilitation can improve brain injury-induced deficits in behavioral flexibility and impulsivity linked to impaired reward-feedback activity.

Posted by klaurent UCSD / Salk

Kavli Affiliate: Dhakshin Ramanathan | Authors: Miranda Francoeur Koloski, Christopher M O’Hearn, Michelle Frankot, Lauren P Giesler, Dhakshin S Ramanathan and Cole Vonder Haar | Summary: Traumatic brain injury (TBI) affects a large population, resulting in severe cognitive impairments. Although cognitive rehabilitation is an accepted treatment for some deficits, studies in patients are limited in […]


Continue.. Cognitive rehabilitation can improve brain injury-induced deficits in behavioral flexibility and impulsivity linked to impaired reward-feedback activity.