Kavli Affiliate: Menno Witter, Jonathan Whitlock | Authors: Karoline Hovde, Ida V. Rautio, Andrea Marie Hegstad, Menno P. Witter and Jonathan R. Whitlock | Summary: Abstract The mammalian visual system can be broadly divided into two functional processing pathways: a dorsal stream supporting visually and spatially guided actions, and a ventral stream enabling object recognition. […]
Kavli Affiliate: Menno Witter, Asgeir Kobro-Flatmoen | Authors: Katrine Sjaastad Hanssen, Menno P. Witter, Axel Sandvig, Ioanna Sandvig and Asgeir Kobro-Flatmoen | Summary: Abstract Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part of the […]
Kavli Affiliate: Vy Thuy Nguyen | Authors: Tino Pleiner, Masami Hazu, Giovani Pinton Tomaleri, Vy N. Nguyen, Kurt Januszyk and Rebecca M. Voorhees | Summary: SUMMARY Tail anchored proteins (TAs) play essential roles at both the ER and mitochondria, and their accurate localization is critical to proteostasis. Biophysical similarities lead to mistargeting of mitochondrial TAs […]
Kavli Affiliate: Bente Jacobsen, Menno Witter, Eirik Nilssen | Authors: Eirik S. Nilssen, Bente Jacobsen, Thanh P. Doan, Paulo J.B. Girao and Menno P. Witter | Summary: ABSTRACT Functionally distinct information encoded by the two main divisions of the entorhinal cortex (EC), the lateral EC (LEC) and the medial EC (MEC), is thought to be […]
Kavli Affiliate: Vy Thuy Nguyen | Authors: Kim Vy Nguyen Ngoc, Somesh Sai, Yesl Jun, R. Hugh F. Bender, Vira Kravets, Han Zhu, Christopher J Hatch, Michael Schlichting, Roberto Gaetani, Medhavi Mallick, Stephanie J Hachey, Karen Christman, Steven Carl George, Christopher C Hughes and Maike Sander | Summary: Abstract Blood vessels play a critical role […]
Kavli Affiliate: Vy Thuy Nguyen | Authors: Mollie Friedlander Qian, Romina J Bevacqua, Vy M Nguyen, Xiong Liu, Weichen Zhao, Charles A Chang, Xueying Gu, Xiao-Qing Dai, Patrick E Macdonald and Seung K. Kim | Summary: ABSTRACT HNF1A haploinsufficiency underlies the most common form of human monogenic diabetes (HNF1A-MODY) and hypomorphic HNF1A variants confer type […]
Kavli Affiliate: Edvard Moser, May-Britt Moser | Authors: Anne Nagelhus, Sebastian Andersson, Soledad Gonzalo Cogno, Edvard I. Moser and May-Britt Moser | Summary: Objects and landmarks are crucial for guiding navigation and must be integrated into the cognitive map of space. Studies of object coding in the hippocampus have primarily focused on activity of single […]
Kavli Affiliate: Menno Witter | Authors: Christiana Bjorkli, Nora Cecilie Ebbesen, Joshua B Julian, Menno P Witter, Axel Sandvig and Ioanna Sandvig | Summary: One of the neuropathological hallmarks of Alzheimer’s disease (AD) is the accumulation of amyloid-β (Aβ) plaques, which is preceded by intraneuronal build-up of toxic, aggregated Aβ during disease progression. Aβ plaques […]
Kavli Affiliate: Menno Witter, Susumu Mori, Michael Miller | Authors: Kaitlin Stouffer, Claire Chen, Sue Kulason, Eileen Xu, Menno Witter, Can Ceritoglu, Marilyn Albert, Susumu Mori, Juan Troncoso, Daniel Jacob Tward and Michael I Miller | Summary: Previous research has emphasized the unique impact of Alzheimer’s Disease (AD) pathology on the medial temporal lobe (MTL), […]
Kavli Affiliate: Simon Ball | Authors: Luke T Slater, John A Williams, Paul N Schofield, Sophie Russell, Samantha C Pendleton, Andreas Karwath, Hilary Fanning, Simon Ball, Robert T Hoehndorf and Georgios V Gkoutos | Summary: Abstract Background Annotation of biomedical entities with ontology terms facilitates the use of background knowledge in analysis. Described entities may […]