Kavli Affiliate: Steven Siegelbaum | Authors: Tobias Bock, Eric W Buss, Olivia M Lofaro, Felix W Leroy, Bina Santoro and Steven A Siegelbaum | Summary: Abstract Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels generate the cationic Ih current in neurons and regulate the excitability of neuronal networks. The function of HCN channels depends, in part, on their […]

Kavli Affiliate: Steven Siegelbaum | Authors: Alexander C Whitebirch, Anastasia Barnett, Bina Santoro, Helen E Scharfman and Steven A Siegelbaum | Summary: ABSTRACT A significant proportion of temporal lobe epilepsy (TLE) patients experience drug-resistant seizures associated with mesial temporal sclerosis, in which there is extensive cell loss in the hippocampal CA1 and CA3 subfields, with […]

Kavli Affiliate: Attila Losonczy | Authors: Zhenrui Liao, Darian Hadjiabadi, Satoshi Terada, Ivan Soltesz and Attila Losonczy | Summary: Summary Memory consolidation assimilates recent experiences into long-term memory. This process requires the replay of learned sequences, though the content of these sequences remains controversial. Recent work has shown that the statistics of replay deviate from […]

Kavli Affiliate: Larry Abbott, Nathaniel Sawtell | Authors: Salomon Zev Muller, Larry F Abbott and Nathaniel B Sawtell | Summary: Abstract Homeostatic (anti-Hebbian) forms of synaptic are effective at eliminating “prediction errors” that signal the differences between predicted and actual sensory input. However, such mechanisms appear to preclude the possibility of transmitting the resulting predictions […]

Kavli Affiliate: Stefano Fusi | Authors: Valeria Fascianelli, Fabio Stefanini, Satoshi Tsujimoto, Aldo Genovesio and Stefano Fusi | Summary: Abstract Animals likely use a variety of strategies to solve laboratory tasks. Traditionally, combined analysis of behavioral and neural recording data across subjects employing different strategies may obscure important signals and give confusing results. Hence it […]

Kavli Affiliate: Costa, Rui | Authors: Paul Botros, Nuria Vendrell-Llopis, Rui Costa and Jose Carmena | Summary: Abstract Throughout learning, refinement of cortical activity in cortex, a process termed “credit assignment”, underlies the refinement of behavioral actions leading to reward. While previous research shows striatum’s role in linking behavior to reward, striatum’s role in linking […]

Kavli Affiliate: C. Daniel Salzman | Authors: David L Barack, Akram Bakkour, Daphna Shohamy and C Daniel Salzman | Summary: Abstract In the real world, making sequences of decisions to achieve goals often depends upon the ability to learn aspects of the environment that are not directly perceptible. Learning these so-called latent features requires seeking […]

Kavli Affiliate: Costa, Rui | Authors: Lina Marcela Carmona, Lin T Tun, An Kim, Rani Shiao, Michael D Kissner, Vilas Menon and Rui M Costa | Summary: ABSTRACT The primary motor cortex (M1) is a central hub for motor learning and execution, as it receives input from and broadcasts to a multitude of other motor […]

Kavli Affiliate: Costa, Rui | Authors: Jonathan C.Y. Tang, Vitor Paixao, Filipe Carvalho, Artur Silva, Andreas Klaus, Joaquim Alves da Silva and Rui M Costa | Summary: Abstract Animals exhibit a diverse behavioral repertoire when exploring new environments and can learn which actions or action sequences produce positive outcomes. Dopamine release upon encountering reward is […]

Kavli Affiliate: Liam Paninski | Authors: James Yu, Amin Nejatbakhsh, Mahdi Torkashvand, Sahana Gangadharan, Maedeh Seyedolmohadesin, Jinmahn Kim, Liam Paninski and Vivek Venkatachalam | Summary: Tracking body parts in behaving animals, extracting fluorescence signals from cells embedded in deforming tissue, and analyzing cell migration patterns during development all require tracking objects with partially correlated motion. […]