Kavli Affiliate: Molly Stevens | Summary:There is a growing trend in molecular and synthetic biology of using mechanistic (non machine learning) models to design biomolecular networks. Once designed, these networks need to be validated by experimental results to ensure the theoretical network correctly models the true system. However, these experiments can be expensive and time […]
Kavli Affiliate: Stephan Rauschenbach | Summary:Using electrospray ion beam deposition, we collide the complex molecule Reichardt’s Dye (C41H30NO+) at low, hyperthermal translational energy (2-50 eV) with a Cu(100) surface and image the outcome at single-molecule level by scanning tunneling microscopy. We observe bond-selective reaction induced by the translational kinetic energy. The collision impulse compresses the […]
Kavli Affiliate: Achillefs Kapanidis | Summary:Single-molecule Förster resonance energy transfer (smFRET) has become a mainstream technique for probing biomolecular structural dynamics. The rapid and wide adoption of the technique by an ever-increasing number of groups has generated many improvements and variations in the technique itself, in methods for sample preparation and characterization, in analysis of […]
Kavli Affiliate: Philipp Kukura | Summary:We present a novel optical transient absorption and reflection microscope based on a diffraction-limited pump pulse in combination with a wide-field probe pulse, for the spatio-temporal investigation of ultrafast population transport in thin films. The microscope achieves a temporal resolution down to 12 fs and simultaneously provides sub-10 nm spatial […]
Kavli Affiliate: Achillefs Kapanidis | Summary:The fluorescent nitrogen-vacancy (NV) defect in diamond has remarkable photophysical properties, including high photostability, which allows stable fluorescence emission for hours; as a result, there has been much interest in using nanodiamonds (NDs) for quantum optics and biological imaging. Such applications have been limited by the complexity and heterogeneity of […]
Kavli Affiliate: Philipp Kukura | Summary:The electric double layer (EDL) formed around charged nanostructures at the liquid-solid interface determines their electrochemical activity and influences their electrical and optical polarizability. We experimentally demonstrate that restructuring of the EDL at the nanoscale can be detected by dark-field scattering microscopy. Temporal and spatial characterization of the scattering signal […]
Kavli Affiliate: Philipp Kukura | Summary:The formation of exciton-polaritons allows the transport of energy over hundreds of nanometres at velocities up to 10^6 m s^-1 in organic semiconductors films in the absence of external cavity structures. | Search Query: arXiv Query: search_query=au:”Kukura Philipp”&id_list=&start=0&max_results=10Read More
Kavli Affiliate: Noel Buckley | Summary:Understanding the morphological changes of primary neuronal cells induced by chemical compounds is essential for drug discovery. Using the data from a single high-throughput imaging assay, a classification model for predicting the biological activity of candidate compounds was introduced. The image recognition model which is based on deep convolutional neural […]
Kavli Affiliate: Stephan Rauschenbach | Summary:A detailed study of the transfer of ions in transfer capillaries of electrospray ion sources is presented. The laminar flow field for various capillary sizes and wall temperatures is calculated. It forms the base of ion transfer simulation of a large number of ions with space charge. This allows to […]
Kavli Affiliate: Richard Berry | Summary:The bacterial flagellar motor is an ion-powered transmembrane protein complex which drives swimming in many bacterial species. The motor consists of a cytoplasmic ‘rotor’ ring and a number of ‘stator’ units, which are bound to the cell wall of the bacterium. Recently, it has been shown that the number of […]