Kavli Affiliate: Daniel Ralph| First 5 Authors: Paul Ralph, Paul Ralph, , , | Summary:Many academics have called for increasing attention to theory in software engineering. Consequently, this paper empirically evaluates two dissimilar software development process theories – one expressing a more traditional, methodical view (FBS) and one expressing an alternative, more improvisational view (SCI). […]

Kavli Affiliate: Christopher Ober| First 5 Authors: Ulrike Ober, Ulrike Ober, , , | Summary:The expected level of linkage disequilibrium (LD) in a finite ideal population at equilibrium is of relevance for many applications in population and quantitative genetics. Several recursion formulae have been proposed during the last decades, whose derivations mostly contain heuristic parts […]

Kavli Affiliate: Daniel Ralph| First 5 Authors: Paul Ralph, Paul Ralph, , , | Summary:It is widely accepted that understanding system requirements is important for software development project success. However, this paper presents two novel challenges to the requirements concept. First, where many plausible approaches to achieving a goal are evident, there may be insufficient […]

Kavli Affiliate: Richard D. Robinson | Summary:In order to fully understand nanoscale heat transport it is necessary to spectrally characterize phonon transmission in nanostructures. Towards this goal we have developed a microfabricated phonon spectrometer. We utilize microfabricated superconducting tunnel junction-based (STJ) phonon transducers for the emission and detection of tunable, non-thermal, and spectrally resolved acoustic […]

Kavli Affiliate: Daniel Ralph| First 5 Authors: Paul Ralph, Paul Ralph, , , | Summary:The dominant view of design in information systems and software engineering, the Rational Design Paradigm, views software development as a methodical, plan-centered, approximately rational process of optimizing a design candidate for known constraints and objectives. This paper synthesizes an Alternative Design […]

Kavli Affiliate: Barbara Baird | Summary:We present an analytical method to quantify clustering in super-resolution localization images of static surfaces in two dimensions. The method also describes how over-counting of labeled molecules contributes to apparent self-clustering and how the effective lateral resolution of an image can be determined. This treatment applies to clustering of proteins […]

Kavli Affiliate: Gerald W. Feigenson | Summary:We have developed a new model to describe FRET efficiency (E FRET) between freely-diffusing membrane probes in phase-separated bilayers (Finite Phase-separation FRET, or FP-FRET), that in principle applies to any system where phase domain dimensions are larger than ~Ro . Here we use Monte Carlo techniques to simulate E […]

Kavli Affiliate: Gerald W. Feigenson | Summary:Multicomponent lipid mixtures exhibit complex phase behavior, including coexistence of nanoscopic fluid phases in ternary mixtures mimicking the composition of the outer leaflet of mammalian plasma membrane. The physical mechanisms responsible for the small size of phase domains are unknown, due in part to the difficulty of determining the […]

Kavli Affiliate: Gerald W. Feigenson | Summary:The presence and the properties of lipid bilayer nanometer-scale domains might be important for understanding the membranes of living cells. We used molecular dynamics (MD) simulations to investigate perturbations of a small patch of fluid-phase DPPC bilayer upon incorporation of fluorescent indocarbocyanine lipid probes commonly used to study membranes […]

Kavli Affiliate: Kyle Shen | First 5 Authors: K. M. Shen, K. M. Shen, , , | Summary: To elucidate the nature of the single-particle excitations in the undoped parent cuprates, we have performed a detailed study of Ca2CuO2Cl2 using photoemission spectroscopy. The photoemission lineshapes of the lower Hubbard band are found to be well-described […]